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学科主题临床医学
Synthesis and in vitro evaluation of three (99m)Tc-labeled hydroxamamide-based ligands as markers for hypoxic cells
Chu, Taiwei1; Xu, Hong1; Yang, Zhi2,3; Wang, Xiangyun1
关键词(99m)Tc complex Hypoxia marker Lipophilicity Hydroxamamide Labeling
刊名APPLIED RADIATION AND ISOTOPES
2009-04-01
DOI10.1016/j.apradiso.2008.12.003
67期:4页:590-593
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Inorganic & Nuclear ; Nuclear Science & Technology ; Radiology, Nuclear Medicine & Medical Imaging
资助者National Natural Science Foundation of China ; Ministry of Science and Technology of China ; Beijing Natural Science Foundation ; National Natural Science Foundation of China ; Ministry of Science and Technology of China ; Beijing Natural Science Foundation
研究领域[WOS]Chemistry ; Nuclear Science & Technology ; Radiology, Nuclear Medicine & Medical Imaging
关键词[WOS]TUMOR HYPOXIA ; TC-99M RADIOPHARMACEUTICALS ; TETRADENTATE LIGANDS
英文摘要

Three new hydroxamamide derivatives with different lipophilicity, N′-hydroxy-N-methyl-3-(4-nitro-1H-imidazol-1-yl)propanamidine, N-butyl-N′-hydroxy-3-(4-nitro-1H-imidazol-1-yl)propanamidine, and N′-hydroxy-3-(4-nitro-1H-imidazol-1-yl)-N-octadecyl propanamidine were easily synthesized and labeled with technetium-99m as markers for hypoxic cells. The results of in vitro experiment indicate that the accumulation of three (99m)Tc-complexes steadily increases with time in hypoxic cells, but fluctuates with time and has no fixed trend in aerobic cells; the complex with higher lipophilicity shows more uptake in cells; and the effect of lipophilicity of the (99m)Tc-complexes on the hypoxic/aerobic difference can be neglected. (C) 2009 Elsevier Ltd. All rights reserved.

语种英语
所属项目编号20771011 ; 2006CB705700 ; 7052015
资助者National Natural Science Foundation of China ; Ministry of Science and Technology of China ; Beijing Natural Science Foundation ; National Natural Science Foundation of China ; Ministry of Science and Technology of China ; Beijing Natural Science Foundation
WOS记录号WOS:000264305500017
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65438
专题北京大学临床肿瘤学院
作者单位1.Peking Univ, BNLMS, Dept Appl Chem, Coll Chem & Mol Engn, Beijing 100871, Peoples R China
2.Peking Univ, Sch Oncol, Beijing 100036, Peoples R China
3.Peking Univ, Beijing Inst Canc Res, Beijing 100036, Peoples R China
推荐引用方式
GB/T 7714
Chu, Taiwei,Xu, Hong,Yang, Zhi,et al. Synthesis and in vitro evaluation of three (99m)Tc-labeled hydroxamamide-based ligands as markers for hypoxic cells[J]. APPLIED RADIATION AND ISOTOPES,2009,67(4):590-593.
APA Chu, Taiwei,Xu, Hong,Yang, Zhi,&Wang, Xiangyun.(2009).Synthesis and in vitro evaluation of three (99m)Tc-labeled hydroxamamide-based ligands as markers for hypoxic cells.APPLIED RADIATION AND ISOTOPES,67(4),590-593.
MLA Chu, Taiwei,et al."Synthesis and in vitro evaluation of three (99m)Tc-labeled hydroxamamide-based ligands as markers for hypoxic cells".APPLIED RADIATION AND ISOTOPES 67.4(2009):590-593.
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