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学科主题: 临床医学
题名:
Preliminary study on proteomics of gastric carcinoma and its clinical significance
作者: Qian, Hong-Gang1,2; Jing-Shen2; Ma, Hong2; Ma, Hua-Chong3; Su, Ya-Hui2; Hao, Chun-Yi2; Xing, Bao-Cai2; Huang, Xin-Fu2; Shou, Cheng-Chao2
关键词: SELDI-TOF-MS ; Serum ; Gastric cancer
刊名: WORLD JOURNAL OF GASTROENTEROLOGY
发表日期: 2005-10-28
卷: 11, 期:40
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Gastroenterology & Hepatology
研究领域[WOS]: Gastroenterology & Hepatology
英文摘要:

AIM: To explore the preliminary identification of serum protein pattern models that may be novel potential biomarkers in the detection of gastric cancer.

METHODS: A total of 130 serum samples, including 70 from patients with gastric cancer and 60 from healthy adults, were detected by surface-enhanced laser desorption and ionization time-of-flight mass spectrometry (SELDI-TOF-MS). The data of spectra were analyzed by Biomarker Patterns Software (BPS). Thirty serum samples of gastric cancer patients and 30 serum samples of healthy adults were grouped into the training group to build models, and the other 70 samples were used to test and evaluate the models. The samples of the test group were judged only with their peaks′ height and were separated into cancer group or healthy control group by BPS automatically and the judgments were checked with the histopathologic diagnosis of the samples.

RESULTS: Sixteen mass peaks were found to be potential biomarkers with a significant level of P<0.01. Among them, nine mass peaks showed increased expression in patients with gastric cancer. Analyzed by BPS, two peaks were chosen to build the model for gastric cancer detection. The sensitivity, specificity, and accuracy of the model were 90%, 36/40, 86.7%, 26/30, and 88.6%, 62/70, respectively, which were greatly higher than those of clinically used serum biomarkers CEA (carcinoembryonic antigen), CA19-9 and CA72-4. Stage I/II gastric cancer samples of the test group were all judged correctly.

CONCLUSION: The novel biomarkers in serum and the established model could be potentially used in the detection of gastric cancer. However, large-scale studies should be carried on to further explore the clinical impact on the model. (C) 2005 The WJG Press and Elsevier Inc. All rights reserved.

语种: 英语
所属项目编号: 20004CB518702
项目资助者: Major State Basic Research Development Program of China (973 Program)
WOS记录号: WOS:000208318000002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65442
Appears in Collections:北京大学临床肿瘤学院_肿瘤外科_期刊论文

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作者单位: 1.Beijing Canc Hosp, Beijing 100036, Peoples R China
2.Beijing Chaoyang Hosp, Beijing 10020, Peoples R China
3.Peking Univ, Sch Clin Oncol, Dept Surg, Beijing 100036, Peoples R China

Recommended Citation:
Qian, Hong-Gang,Jing-Shen,Ma, Hong,et al. Preliminary study on proteomics of gastric carcinoma and its clinical significance[J]. WORLD JOURNAL OF GASTROENTEROLOGY,2005,11(40).
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