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学科主题: 药学
题名:
The effects of chain number and state of lipid derivatives of nucleosides on hydrogen bonding and self-assembly through the investigation of Langmuir-Blodgett films
作者: Jin, Yiguang; Qiao, Yingxin; Hou, Xinpu
关键词: hydrogen bonding ; self-assembly ; nucleosides ; Langmuir-Blodgett films ; ultraviolet absorption spectroscopy ; atomic force microscope
刊名: APPLIED SURFACE SCIENCE
发表日期: 2006-09-15
DOI: 10.1016/j.apsusc.2005.09.073
卷: 252, 期:22, 页:7926-7929
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Physical ; Materials Science, Coatings & Films ; Physics, Applied ; Physics, Condensed Matter
研究领域[WOS]: Chemistry ; Materials Science ; Physics
英文摘要:

The long-chain lipid derivatives of acyclovir-a nucleoside analogue were used to prepare Langmuir-Blodgett (LB) films, including the single-chained derivative (SGSA) and the double-chained derivative (DASA). The bilayer LB film of DASA or the SGSA/cholesterol (SGSA/Chol) mixture (1:1, mol/mol) on quartz plates was investigated with ultraviolet absorption spectroscopy, and the blue-shifted absorption with 4 nm (DASA) or 18 nm (SGSA/Chol) wavelength changes was observed in comparison with their solutions in chloroform. The rigid double chains of DASA prevented adjacent molecules from approach, while the flexible single chains of SGSA did not. Then the strength of intermolecular hydrogen bonding between the nucleoside moieties of DASA was much more weaker than one of SGSA, and their blue-shifted wavelength in LB films was different. DASA and SGSA/Chol also showed the different bilayer LB films on mica according to the atomic force microscopic observation. The former was prone to tilting on solid supports while the latter would like to stand vertically with the help of cholesterol that could insert into the flexible single chains of SGSA. The chain number (one or two) and state (flexible or rigid) of lipid derivatives of nucleosides strongly impact intermolecular hydrogen bonding and self-assembly behavior. (c) 2005 Elsevier B.V. All rights reserved.

语种: 英语
WOS记录号: WOS:000240792100030
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65450
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Beijing Inst Radiat Med, Dept Pharmaceut Chem, Beijing 100850, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, Dept Phys Pharm, Beijing 100083, Peoples R China

Recommended Citation:
Jin, Yiguang,Qiao, Yingxin,Hou, Xinpu. The effects of chain number and state of lipid derivatives of nucleosides on hydrogen bonding and self-assembly through the investigation of Langmuir-Blodgett films[J]. APPLIED SURFACE SCIENCE,2006,252(22):7926-7929.
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