IR@PKUHSC  > 北京大学基础医学院  > 神经生物学系
学科主题基础医学
Characteristics of HCN channels and their participation in neuropathic pain
Jiang, Yu-Qiu1,2; Sun, Qian1; Tu, Hui-Yin1; Wan, You1,2,3
关键词hyperpolarization-activated cyclic nucleotide gated cation channels (HCN) I(h) neuropathic pain ectopic discharges peripheral sensitization ZD7288
刊名NEUROCHEMICAL RESEARCH
2008-10-01
DOI10.1007/s11064-008-9717-6
33期:10页:1979-1989
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Neurosciences
研究领域[WOS]Biochemistry & Molecular Biology ; Neurosciences & Neurology
关键词[WOS]ACTIVATED CATION CURRENT ; DORSAL-ROOT GANGLION ; CURRENT I-H ; PRIMARY SENSORY NEURONS ; NUCLEOTIDE-GATED CHANNELS ; PRIMARY AFFERENT NEURONS ; NERVE INJURY ; PACEMAKER CHANNELS ; ION CHANNELS ; SYNAPTIC-TRANSMISSION
英文摘要

Neuropathic pain is induced by the injury to nervous systems and characterized by hyperalgesia, allodynia and spontaneous pain. The underlying mechanisms include peripheral and central sensitization resulted from neuronal hyperexcitability. A number of ion channels are considered to contribute to the neuronal hyperexcitability. Here, we particularly concentrate on an interesting ion channel, hyperpolarization-activated cyclic nucleotide gated (HCN) channels. We overview its biophysical properties, physiological functions, followed by focusing on the current progress in the study of its role in the development of neuropathic pain. We attempt to provide a comprehensive review of the potential valuable target, HCN channels, in the treatment of neuropathic pain.

语种英语
WOS记录号WOS:000259190900011
项目编号7052039 ; 30600173 ; 30570566 ; 30470559 ; 30330230 ; 2007CB512501
资助机构Beijing Natural Science Foundation ; National Natural Science Foundation of China ; Ministry of Science and Technology of China
引用统计
被引频次:43[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65455
专题北京大学基础医学院_神经生物学系
北京大学基础医学院
作者单位1.Peking Univ, Neurosci Res Inst, Beijing 100083, Peoples R China
2.Peking Univ, Dept Neurobiol, Beijing 100083, Peoples R China
3.Peking Univ, Key Lab Neurosci, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Jiang, Yu-Qiu,Sun, Qian,Tu, Hui-Yin,et al. Characteristics of HCN channels and their participation in neuropathic pain[J]. NEUROCHEMICAL RESEARCH,2008,33(10):1979-1989.
APA Jiang, Yu-Qiu,Sun, Qian,Tu, Hui-Yin,&Wan, You.(2008).Characteristics of HCN channels and their participation in neuropathic pain.NEUROCHEMICAL RESEARCH,33(10),1979-1989.
MLA Jiang, Yu-Qiu,et al."Characteristics of HCN channels and their participation in neuropathic pain".NEUROCHEMICAL RESEARCH 33.10(2008):1979-1989.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
Characteristics of H(366KB)期刊论文出版稿开放获取CC BY-NC-SA浏览 请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Jiang, Yu-Qiu]的文章
[Sun, Qian]的文章
[Tu, Hui-Yin]的文章
百度学术
百度学术中相似的文章
[Jiang, Yu-Qiu]的文章
[Sun, Qian]的文章
[Tu, Hui-Yin]的文章
必应学术
必应学术中相似的文章
[Jiang, Yu-Qiu]的文章
[Sun, Qian]的文章
[Tu, Hui-Yin]的文章
相关权益政策
暂无数据
收藏/分享
文件名: Characteristics of HCN channels and their participation in neuropathic pain.pdf
格式: Adobe PDF
此文件暂不支持浏览
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。