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学科主题: 基础医学
题名:
Characteristics of HCN channels and their participation in neuropathic pain
作者: Jiang, Yu-Qiu1,2; Sun, Qian1; Tu, Hui-Yin1; Wan, You1,2,3
关键词: hyperpolarization-activated cyclic nucleotide gated cation channels (HCN) ; I(h) ; neuropathic pain ; ectopic discharges ; peripheral sensitization ; ZD7288
刊名: NEUROCHEMICAL RESEARCH
发表日期: 2008-10-01
DOI: 10.1007/s11064-008-9717-6
卷: 33, 期:10, 页:1979-1989
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Neurosciences
研究领域[WOS]: Biochemistry & Molecular Biology ; Neurosciences & Neurology
关键词[WOS]: ACTIVATED CATION CURRENT ; DORSAL-ROOT GANGLION ; CURRENT I-H ; PRIMARY SENSORY NEURONS ; NUCLEOTIDE-GATED CHANNELS ; PRIMARY AFFERENT NEURONS ; NERVE INJURY ; PACEMAKER CHANNELS ; ION CHANNELS ; SYNAPTIC-TRANSMISSION
英文摘要:

Neuropathic pain is induced by the injury to nervous systems and characterized by hyperalgesia, allodynia and spontaneous pain. The underlying mechanisms include peripheral and central sensitization resulted from neuronal hyperexcitability. A number of ion channels are considered to contribute to the neuronal hyperexcitability. Here, we particularly concentrate on an interesting ion channel, hyperpolarization-activated cyclic nucleotide gated (HCN) channels. We overview its biophysical properties, physiological functions, followed by focusing on the current progress in the study of its role in the development of neuropathic pain. We attempt to provide a comprehensive review of the potential valuable target, HCN channels, in the treatment of neuropathic pain.

语种: 英语
所属项目编号: 7052039 ; 30600173 ; 30570566 ; 30470559 ; 30330230 ; 2007CB512501
项目资助者: Beijing Natural Science Foundation ; National Natural Science Foundation of China ; Ministry of Science and Technology of China
WOS记录号: WOS:000259190900011
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65455
Appears in Collections:基础医学院_神经生物学系_期刊论文

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作者单位: 1.Peking Univ, Neurosci Res Inst, Beijing 100083, Peoples R China
2.Peking Univ, Dept Neurobiol, Beijing 100083, Peoples R China
3.Peking Univ, Key Lab Neurosci, Beijing 100083, Peoples R China

Recommended Citation:
Jiang, Yu-Qiu,Sun, Qian,Tu, Hui-Yin,et al. Characteristics of HCN channels and their participation in neuropathic pain[J]. NEUROCHEMICAL RESEARCH,2008,33(10):1979-1989.
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