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The clinical performance of APTIMA human papillomavirus and Hybrid Capture 2 assays in the triage of lesser abnormal cervical cytologies
Guo, Yanli; You, Ke; Geng, Li; Qiao, Jie
关键词Early detection of cancer Human Papillomavirus Triage Uterine cervical dysplasia Uterine cervical neoplasms
刊名JOURNAL OF GYNECOLOGIC ONCOLOGY
2014-10-01
DOI10.3802/jgo.2014.25.4.287
25期:4页:287-292
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology ; Obstetrics & Gynecology
研究领域[WOS]Oncology ; Obstetrics & Gynecology
关键词[WOS]INTRAEPITHELIAL NEOPLASIA ; MESSENGER-RNA ; SCREENING-TESTS ; HPV ASSAY ; CANCER ; DNA ; WOMEN ; RISK ; IMPLEMENTATION ; TRANSCRIPTS
英文摘要

Objective: This study was performed to evaluate the clinical performance of APTIMA human papillomavirus (AHPV) assay and Hybrid Capture 2 (HC2) assay in screening for cervical disease, especially in women with atypical squamous Cell of undetermined significance (ASC-US) and low-grade squamous intraepithelial lesion (LSIL).

Methods: A total of 411 women diagnosed with ASC-US or LSIL were referred and further triaged by HC2 test. Prior to colposcopy, liquid-based cytology specimens were collected for the AHPV assay. Sensitivity and specificity were established based on the histological findings of cervical intraepithelial neoplasia (CIN).

Results: In all 411 subjects, the positive detection rate of AHPV assay was 70.8% (95% confidence interval [CI], 66.4 to 75.2), which was significantly lower than the positive detection rate of 94.9% obtained using HC2 test (95% CI, 92.3 to 96.8). Only one CIN 3-positive case was detected among the 120 AHPV-negative women, which was then confirmed by Pap smear test to be LSIL. The sensitivities of AHPV and HC2 for CIN 3 were similar (94.1% and 100%, respectively). However, AHPV showed a significantly higher specificity than HC2 test (30.2% and 5.3%, respectively; p<0.001).

Conclusion: AHPV assay is effective in identifying CIN 3-positive cases because of its high specificity and lower false-negative rate. The use of AHPV for the triage of ASC-US and LSIL might help to reduce the referral rate of colposcopy during cervical cancer screening.

语种英语
WOS记录号WOS:000343022600008
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65457
专题北京大学第三临床医学院
北京大学第三临床医学院_妇产科
北京大学第三临床医学院_生殖医学中心
作者单位Peking Univ, Hosp 3, Dept Obstet & Gynecol, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Guo, Yanli,You, Ke,Geng, Li,et al. The clinical performance of APTIMA human papillomavirus and Hybrid Capture 2 assays in the triage of lesser abnormal cervical cytologies[J]. JOURNAL OF GYNECOLOGIC ONCOLOGY,2014,25(4):287-292.
APA Guo, Yanli,You, Ke,Geng, Li,&Qiao, Jie.(2014).The clinical performance of APTIMA human papillomavirus and Hybrid Capture 2 assays in the triage of lesser abnormal cervical cytologies.JOURNAL OF GYNECOLOGIC ONCOLOGY,25(4),287-292.
MLA Guo, Yanli,et al."The clinical performance of APTIMA human papillomavirus and Hybrid Capture 2 assays in the triage of lesser abnormal cervical cytologies".JOURNAL OF GYNECOLOGIC ONCOLOGY 25.4(2014):287-292.
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