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学科主题: 临床医学
题名:
The clinical performance of APTIMA human papillomavirus and Hybrid Capture 2 assays in the triage of lesser abnormal cervical cytologies
作者: Guo, Yanli; You, Ke; Geng, Li; Qiao, Jie
关键词: Early detection of cancer ; Human Papillomavirus ; Triage ; Uterine cervical dysplasia ; Uterine cervical neoplasms
刊名: JOURNAL OF GYNECOLOGIC ONCOLOGY
发表日期: 2014-10-01
DOI: 10.3802/jgo.2014.25.4.287
卷: 25, 期:4, 页:287-292
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology ; Obstetrics & Gynecology
研究领域[WOS]: Oncology ; Obstetrics & Gynecology
关键词[WOS]: INTRAEPITHELIAL NEOPLASIA ; MESSENGER-RNA ; SCREENING-TESTS ; HPV ASSAY ; CANCER ; DNA ; WOMEN ; RISK ; IMPLEMENTATION ; TRANSCRIPTS
英文摘要:

Objective: This study was performed to evaluate the clinical performance of APTIMA human papillomavirus (AHPV) assay and Hybrid Capture 2 (HC2) assay in screening for cervical disease, especially in women with atypical squamous Cell of undetermined significance (ASC-US) and low-grade squamous intraepithelial lesion (LSIL).

Methods: A total of 411 women diagnosed with ASC-US or LSIL were referred and further triaged by HC2 test. Prior to colposcopy, liquid-based cytology specimens were collected for the AHPV assay. Sensitivity and specificity were established based on the histological findings of cervical intraepithelial neoplasia (CIN).

Results: In all 411 subjects, the positive detection rate of AHPV assay was 70.8% (95% confidence interval [CI], 66.4 to 75.2), which was significantly lower than the positive detection rate of 94.9% obtained using HC2 test (95% CI, 92.3 to 96.8). Only one CIN 3-positive case was detected among the 120 AHPV-negative women, which was then confirmed by Pap smear test to be LSIL. The sensitivities of AHPV and HC2 for CIN 3 were similar (94.1% and 100%, respectively). However, AHPV showed a significantly higher specificity than HC2 test (30.2% and 5.3%, respectively; p<0.001).

Conclusion: AHPV assay is effective in identifying CIN 3-positive cases because of its high specificity and lower false-negative rate. The use of AHPV for the triage of ASC-US and LSIL might help to reduce the referral rate of colposcopy during cervical cancer screening.

语种: 英语
WOS记录号: WOS:000343022600008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65457
Appears in Collections:北京大学第三临床医学院_期刊论文

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作者单位: Peking Univ, Hosp 3, Dept Obstet & Gynecol, Beijing 100191, Peoples R China

Recommended Citation:
Guo, Yanli,You, Ke,Geng, Li,et al. The clinical performance of APTIMA human papillomavirus and Hybrid Capture 2 assays in the triage of lesser abnormal cervical cytologies[J]. JOURNAL OF GYNECOLOGIC ONCOLOGY,2014,25(4):287-292.
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