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学科主题: 临床医学
题名:
Evaluation of Multiparametric Magnetic Resonance Imaging in Detection and Prediction of Prostate Cancer
作者: Wang, Rui1; Wang, He1; Zhao, Chenglin1; Hu, Juan2; Jiang, Yuanyuan1; Tong, Yanjun3; Liu, Ting4; Huang, Rong5; Wang, Xiaoying1
刊名: PLOS ONE
发表日期: 2015-06-12
DOI: 10.1371/journal.pone.0130207
卷: 10, 期:6
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: ACTIVE SURVEILLANCE ; BIOPSY ; MRI ; DIAGNOSIS ; MORTALITY ; RISK ; PSA
英文摘要:

Background

Although European Society of Urogenital Radiology proposed the potential of multiparametric magnetic resonance imaging (MP-MRI) as a tool in the diagnostic pathway for prostate cancer (PCa) and published a unified scoring system named Prostate Imaging Reporting and Data System (PI-RADS version 1), these still need to be validated by real-life studies.

Objective

To evaluate the role of MP-MRI in detection and prediction of PCa.

Methods

Patients with clinical suspicion of PCa who underwent prebiopsy MP-MRI from 2002 to 2009 were recruited. MP-MRI results were retrospectively assigned as overall scores using PI-RADS by two radiologists. Patients were followed and the end point was the diagnosis of PCa. Receiver operating characteristics (ROC) curve was performed to test diagnostic efficacy of MP-MRI, under results of biopsy within three months. The cox proportional hazards model was used to identify independent variables for the detection of PCa.

Results

Finally, 1113 of the 1806 enrolled patients were included for analysis. The median follow-up was 56.0 months (1-137 mo). For 582 patients biopsied within three months, area under the curve for the detection of PCa with MP-MRI was 0.88 (95% confidence interval [CI], 0.75-1.00) in group of baseline prostate specific antigen (PSA) 0.01-4.00 ng/ml (n = 31), 0.90 (95% CI, 0.84-0.95) in PSA 4.01-10.00 ng/ml (n = 142), and 0.91 (95% CI, 0.87-0.94) in PSA > 10.00 ng/ml (n = 409), respectively. In the cox model adjusted for age and baseline PSA level, for the detection rate of PCa, compared with PI-RADS 1-2 (reference), the hazard ratio was 6.43 (95% CI, 4.29-9.65) for PI-RADS 3, 18.58 (95% CI, 13.36-25.84) for PIRADS 4-5 (p < 0.001).

Conclusions

Prebiopsy MP-MRI with PI-RADS is demonstrated as a valuable diagnostic and predictive tool for PCa.

语种: 英语
WOS记录号: WOS:000356327000150
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65463
Appears in Collections:北京大学第一临床医学院_放射治疗科_期刊论文

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作者单位: 1.Aerosp Cent Hosp, Dept Radiol, Beijing, Peoples R China
2.Peking Univ, Hosp 1, Dept Radiol, Beijing 100871, Peoples R China
3.Kunming Med Univ, Affiliated Hosp 1, Dept Radiol, Yunnan, Peoples R China
4.Dongzhimen Hosp, Dept Radiol, Beijing, Peoples R China
5.Peking Univ, Dept Radiol, Shenzhen Hosp, Shenzhen, Guangdong, Peoples R China

Recommended Citation:
Wang, Rui,Wang, He,Zhao, Chenglin,et al. Evaluation of Multiparametric Magnetic Resonance Imaging in Detection and Prediction of Prostate Cancer[J]. PLOS ONE,2015,10(6).
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