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学科主题: 临床医学
题名:
Genetic variation in IL28B is associated with the development of hepatitis B-related hepatocellular carcinoma
作者: Ren, Shan1; Lu, Junfeng1; Du, Xiaofei1; Huang, Yanxiang1; Ma, Lina1; Huo, Honglei1; Chen, Xinyue1; Wei, Lai2
关键词: Hepatitis B virus (HBV) ; Interleukin 28B ; Hepatocellular carcinoma ; Genetic polymorphism ; Interferon-lambda
刊名: CANCER IMMUNOLOGY IMMUNOTHERAPY
发表日期: 2012-09-01
DOI: 10.1007/s00262-012-1203-y
卷: 61, 期:9, 页:1433-1439
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology ; Immunology
研究领域[WOS]: Oncology ; Immunology
关键词[WOS]: GENOME-WIDE ASSOCIATION ; LAMBDA-INTERFERON ; VIRUS-REPLICATION ; IFN-LAMBDA ; DNA LEVEL ; C VIRUS ; CELLS ; RISK ; MACROPHAGES ; CLEARANCE
英文摘要:

To evaluate the role of host IL28B (interleukin 28B; interferon lambda 3) single nucleotide polymorphisms (SNPs) in predicting hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) susceptibility, three SNPs in the IL28B gene (rs12979860C/T, rs8099917G/T and rs12980275G/A) were examined in 330 subjects (including 154 HBV-related HCC patients, 86 non-HCC patients with chronic hepatitis B (CHB), 43 HBV self-limited infections and 47 healthy controls). Notably, the frequency of CC homozygosity was 91.5% in healthy controls and 72.9% in CHB, the difference being statistically significant (chi (2) = 6.40, P = 0.01). The statistically difference was seen between healthy controls (91.5%) and HCC (74.7%) (chi (2) = 6.05, P = 0.01). However, this significant finding was not seen between HBV self-limited and healthy controls. Carriers of the minor T allele in rs12979860 had a higher risk of HCC compared with non-carriers (chi (2) = 4.44, P = 0.04). Haplotype analyses revealed significant association between haplotype C-T-A and healthy controls, but not with the HCC group (96.6 vs. 82.0%, chi (2) = 6.08, P = 0.01). Analyses of genotype combination and gene-gene interaction showed that there was a positive interaction between rs12979860 and rs12980275, with an OR rate of 11.79 (likelihood test, P = 0.04). Our results suggest that the IL28B rs12979860 C/T polymorphism might affect susceptibility to the chronic HBV infection and progression of HCC. Of note, the T allele and non-CC genotypes have strong predictive effect of increasing susceptibility of chronic HBV infection and HCC.

语种: 英语
所属项目编号: 2008ZX10002-013 ; 2012ZX10002-003
项目资助者: National Eleventh Five-year Science and Technology Major Projects, China ; National Twelfth Five-year Science and Technology Major Projects, China
WOS记录号: WOS:000307981300009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65464
Appears in Collections:北京大学第二临床医学院_北京大学肝病研究所_期刊论文

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作者单位: 1.Capital Med Univ, Beijing Youan Hosp, Beijing 100069, Peoples R China
2.Peking Univ, Peoples Hosp, Inst Hepatol, Beijing 100044, Peoples R China

Recommended Citation:
Ren, Shan,Lu, Junfeng,Du, Xiaofei,et al. Genetic variation in IL28B is associated with the development of hepatitis B-related hepatocellular carcinoma[J]. CANCER IMMUNOLOGY IMMUNOTHERAPY,2012,61(9):1433-1439.
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