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学科主题临床医学
Invasive Pulmonary Aspergillosis in Patients With Antineutrophil Cytoplasmic Antibody Associated Vasculitis
Su, Tao1,2,3; Li, Hai-Chao4; Chen, Min1,2,3; Gao, Li5; Zhou, Fu-de1,2,3; Wang, Ren-Gui5; Zhang, Hong1,2,3; Li, Xiao-Mei1,2,3; Zhao, Ming-Hui1,2,3
关键词invasive pulmonary aspergillosis ANCA vasculitis mortality
刊名JCR-JOURNAL OF CLINICAL RHEUMATOLOGY
2009-12-01
DOI10.1097/RHU.0b013e31819e67b1
15期:8页:380-382
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Rheumatology
研究领域[WOS]Rheumatology
关键词[WOS]CELL TRANSPLANT RECIPIENTS ; CRITICALLY-ILL PATIENTS ; IMMUNOCOMPROMISED PATIENTS ; CORTICOSTEROID TREATMENT ; INTERNATIONAL CONSENSUS ; SYSTEMIC VASCULITIDES ; FUNGAL-INFECTIONS ; DISEASE ; EPIDEMIOLOGY ; MANAGEMENT
英文摘要

Background and Aims: Invasive pulmonary aspergillosis (IPA) has been reported as a severe opportunistic infection in immunocompromised patients without neutropenia or cancer. Patients with antineutrophil cytoplasmic antibody associated vasculitis (AAV) with immunosuppressive treatment are susceptible to IPA, but only few cases were reported in the literature. We retrospectively analyze the clinical characteristics of our patients with IPA in AAV.

Methods: Hospitalized patients with AAV who developed IPA were selected. Their clinical data were retrospectively reviewed and possible risk factors for development of IPA were investigated.

Results: Seven of 157 patients with AAV were identified to have IPA. Two patients were classified as Wegener granulomatosis and 5 as microscopic polyangiitis with a mean age at 68.6 +/- 10.9 years. After immunosuppressive therapy, 7 patients developed IPA within 2 similar to 13 weeks. They had 1 or more risk factors increasing susceptibility to Aspergillus. Pre-existing chronic respiratory diseases were found in 5 patients. Despite intensive antifungal therapy, only 3 patients survived. The patients who died were older, with more severe lung injury and lower hemoglobin level.

Conclusions: AAV patients with immunosuppressive therapy are susceptible to Aspergillus infection. Monitoring and prophylactic antifungal therapy should be recommended for patients at high risk.

语种英语
WOS记录号WOS:000272659100002
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65467
专题北京大学第一临床医学院_肾脏内科
北京大学第一临床医学院_放射治疗科
北京大学第一临床医学院_呼吸科
作者单位1.Peking Univ, Inst Nephrol, Beijing 100034, Peoples R China
2.Minist Hlth China, Key Lab Renal Dis, Beijing 100034, Peoples R China
3.Peking Univ, Hosp 1, Div Renal, Dept Med, Beijing 100034, Peoples R China
4.Peking Univ, Hosp 1, Div Resp, Dept Med, Beijing 100034, Peoples R China
5.Peking Univ, Hosp 1, Dept Radiol, Beijing 100034, Peoples R China
推荐引用方式
GB/T 7714
Su, Tao,Li, Hai-Chao,Chen, Min,et al. Invasive Pulmonary Aspergillosis in Patients With Antineutrophil Cytoplasmic Antibody Associated Vasculitis[J]. JCR-JOURNAL OF CLINICAL RHEUMATOLOGY,2009,15(8):380-382.
APA Su, Tao.,Li, Hai-Chao.,Chen, Min.,Gao, Li.,Zhou, Fu-de.,...&Zhao, Ming-Hui.(2009).Invasive Pulmonary Aspergillosis in Patients With Antineutrophil Cytoplasmic Antibody Associated Vasculitis.JCR-JOURNAL OF CLINICAL RHEUMATOLOGY,15(8),380-382.
MLA Su, Tao,et al."Invasive Pulmonary Aspergillosis in Patients With Antineutrophil Cytoplasmic Antibody Associated Vasculitis".JCR-JOURNAL OF CLINICAL RHEUMATOLOGY 15.8(2009):380-382.
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