|Invasive Pulmonary Aspergillosis in Patients With Antineutrophil Cytoplasmic Antibody Associated Vasculitis|
|Su, Tao1,2,3; Li, Hai-Chao4; Chen, Min1,2,3; Gao, Li5; Zhou, Fu-de1,2,3; Wang, Ren-Gui5; Zhang, Hong1,2,3; Li, Xiao-Mei1,2,3; Zhao, Ming-Hui1,2,3|
|关键词||invasive pulmonary aspergillosis ANCA vasculitis mortality|
|刊名||JCR-JOURNAL OF CLINICAL RHEUMATOLOGY|
|WOS标题词||Science & Technology|
|关键词[WOS]||CELL TRANSPLANT RECIPIENTS ; CRITICALLY-ILL PATIENTS ; IMMUNOCOMPROMISED PATIENTS ; CORTICOSTEROID TREATMENT ; INTERNATIONAL CONSENSUS ; SYSTEMIC VASCULITIDES ; FUNGAL-INFECTIONS ; DISEASE ; EPIDEMIOLOGY ; MANAGEMENT|
Background and Aims: Invasive pulmonary aspergillosis (IPA) has been reported as a severe opportunistic infection in immunocompromised patients without neutropenia or cancer. Patients with antineutrophil cytoplasmic antibody associated vasculitis (AAV) with immunosuppressive treatment are susceptible to IPA, but only few cases were reported in the literature. We retrospectively analyze the clinical characteristics of our patients with IPA in AAV.
Methods: Hospitalized patients with AAV who developed IPA were selected. Their clinical data were retrospectively reviewed and possible risk factors for development of IPA were investigated.
Results: Seven of 157 patients with AAV were identified to have IPA. Two patients were classified as Wegener granulomatosis and 5 as microscopic polyangiitis with a mean age at 68.6 +/- 10.9 years. After immunosuppressive therapy, 7 patients developed IPA within 2 similar to 13 weeks. They had 1 or more risk factors increasing susceptibility to Aspergillus. Pre-existing chronic respiratory diseases were found in 5 patients. Despite intensive antifungal therapy, only 3 patients survived. The patients who died were older, with more severe lung injury and lower hemoglobin level.
Conclusions: AAV patients with immunosuppressive therapy are susceptible to Aspergillus infection. Monitoring and prophylactic antifungal therapy should be recommended for patients at high risk.
|作者单位||1.Peking Univ, Inst Nephrol, Beijing 100034, Peoples R China|
2.Minist Hlth China, Key Lab Renal Dis, Beijing 100034, Peoples R China
3.Peking Univ, Hosp 1, Div Renal, Dept Med, Beijing 100034, Peoples R China
4.Peking Univ, Hosp 1, Div Resp, Dept Med, Beijing 100034, Peoples R China
5.Peking Univ, Hosp 1, Dept Radiol, Beijing 100034, Peoples R China
|Su, Tao,Li, Hai-Chao,Chen, Min,et al. Invasive Pulmonary Aspergillosis in Patients With Antineutrophil Cytoplasmic Antibody Associated Vasculitis[J]. JCR-JOURNAL OF CLINICAL RHEUMATOLOGY,2009,15(8):380-382.|
|APA||Su, Tao.,Li, Hai-Chao.,Chen, Min.,Gao, Li.,Zhou, Fu-de.,...&Zhao, Ming-Hui.(2009).Invasive Pulmonary Aspergillosis in Patients With Antineutrophil Cytoplasmic Antibody Associated Vasculitis.JCR-JOURNAL OF CLINICAL RHEUMATOLOGY,15(8),380-382.|
|MLA||Su, Tao,et al."Invasive Pulmonary Aspergillosis in Patients With Antineutrophil Cytoplasmic Antibody Associated Vasculitis".JCR-JOURNAL OF CLINICAL RHEUMATOLOGY 15.8(2009):380-382.|