|Efficacy of Combined Amlodipine/Terazosin Therapy in Male Hypertensive Patients With Lower Urinary Tract Symptoms: A Randomized, Double-blind Clinical Trial|
|Liu, Haipeng; Liu, Ping; Mao, Guangyun; Chen, Guangliang; Wang, Binyan; Qin, Xianhui; Na, Yanqun; Liu, Zeyuan; Wang, Xiaobin; Xu, Xiping1|
|WOS标题词||Science & Technology|
|类目[WOS]||Urology & Nephrology|
|研究领域[WOS]||Urology & Nephrology|
|关键词[WOS]||BENIGN PROSTATIC HYPERPLASIA ; RISK-FACTORS ; OVERACTIVE BLADDER ; BLOOD-PRESSURE ; SMOOTH-MUSCLE ; TERAZOSIN ; MEN ; DOXAZOSIN ; TOLTERODINE ; POPULATION|
OBJECTIVES To investigate the therapeutic efficacy and safety of Amlodipine alone or in combination with terazosin for the presence of lower urinary tract symptoms (LUTS) and hypertension. LUTS and hypertension often coexist in elderly men.
METHODS A total of 355 patients with Stage I or 2 hypertension and LUTS (as defined by an International Prostate Symptom Score of >= 10) were randomly assigned to receive 2 mg of terazosin (n = 117), 5 mg of Amlodipine (n = 119), or 5 mg of Amlodipine plus 2 mg of terazosin (n = 119) once daily for a total of 28 days. The primary outcomes were a reduction in the total and subscores of the International Prostate Symptom Score and blood pressure. Analyses were performed by intention to treat. This trial is registered with ClinicalTrials.gov (No. NCT00693199).
RESULTS At day 28 of the trial, the Amlodipine Plus terazosin group demonstrated comparable efficacy in lowering the total International Prostate Symptom Score and significant improvement in the presence of overactive bladder compared with the terazosin group (P < .05) and significant improvement in quality of life compared with the Amlodipine group (P < .05). The Amlodipine plus terazosin group also achieved the greatest blood pressure control compared with either the terazosin group (P < .01) or Amlodipine group (P < .05). All 3 treatment regimens were well tolerated by the study patients.
CONCLUSIONS The results of this 4-week, double-blind, randomized trial have demonstrated that in Chinese male hypertensive patients with LUTS, low-dose Amlodipine plus terazosin therapy appears to be a safe and effective combination therapy to control both conditions, especially for those with predominant overactive bladder symptoms. UROLOGY 74: 130-136, 2009. (c) 2009 Elsevier Inc. All rights reserved.
|作者单位||1.Peking Univ, Dept Urol, Hosp 1, Beijing 100871, Peoples R China|
2.Anhui Med Univ, Inst Biomed, Hefei, Anhui, Peoples R China
3.Univ Illinois, Sch Publ Hlth, Chicago, IL 60612 USA
4.Univ Sci & Technol China, Sch Life Sci, Hefei 230026, Anhui, Peoples R China
5.Wenzhou Med Coll, Sch Publ Hlth, Wenzhou, Zhejiang, Peoples R China
6.Acad Mil Med Sci China, Dept Clin Pharmacol, Affiliated Hosp 1, Beijing, Peoples R China
7.Northwestern Univ, Childrens Mem Hosp, Feinberg Sch Med, Mary Ann & J Milburn Smith Child Hlth Res Program, Chicago, IL 60614 USA
8.Northwestern Univ, Childrens Mem Res Ctr, Feinberg Sch Med, Chicago, IL 60614 USA
|Liu, Haipeng,Liu, Ping,Mao, Guangyun,et al. Efficacy of Combined Amlodipine/Terazosin Therapy in Male Hypertensive Patients With Lower Urinary Tract Symptoms: A Randomized, Double-blind Clinical Trial[J]. UROLOGY,2009,74(1):130-136.|
|APA||Liu, Haipeng.,Liu, Ping.,Mao, Guangyun.,Chen, Guangliang.,Wang, Binyan.,...&Xu, Xiping.(2009).Efficacy of Combined Amlodipine/Terazosin Therapy in Male Hypertensive Patients With Lower Urinary Tract Symptoms: A Randomized, Double-blind Clinical Trial.UROLOGY,74(1),130-136.|
|MLA||Liu, Haipeng,et al."Efficacy of Combined Amlodipine/Terazosin Therapy in Male Hypertensive Patients With Lower Urinary Tract Symptoms: A Randomized, Double-blind Clinical Trial".UROLOGY 74.1(2009):130-136.|