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Efficacy of Combined Amlodipine/Terazosin Therapy in Male Hypertensive Patients With Lower Urinary Tract Symptoms: A Randomized, Double-blind Clinical Trial
Liu, Haipeng; Liu, Ping; Mao, Guangyun; Chen, Guangliang; Wang, Binyan; Qin, Xianhui; Na, Yanqun; Liu, Zeyuan; Wang, Xiaobin; Xu, Xiping1
刊名UROLOGY
2009-07-01
DOI10.1016/j.urology.2008.11.051
74期:1页:130-136
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Urology & Nephrology
研究领域[WOS]Urology & Nephrology
关键词[WOS]BENIGN PROSTATIC HYPERPLASIA ; RISK-FACTORS ; OVERACTIVE BLADDER ; BLOOD-PRESSURE ; SMOOTH-MUSCLE ; TERAZOSIN ; MEN ; DOXAZOSIN ; TOLTERODINE ; POPULATION
英文摘要

OBJECTIVES To investigate the therapeutic efficacy and safety of Amlodipine alone or in combination with terazosin for the presence of lower urinary tract symptoms (LUTS) and hypertension. LUTS and hypertension often coexist in elderly men.

METHODS A total of 355 patients with Stage I or 2 hypertension and LUTS (as defined by an International Prostate Symptom Score of >= 10) were randomly assigned to receive 2 mg of terazosin (n = 117), 5 mg of Amlodipine (n = 119), or 5 mg of Amlodipine plus 2 mg of terazosin (n = 119) once daily for a total of 28 days. The primary outcomes were a reduction in the total and subscores of the International Prostate Symptom Score and blood pressure. Analyses were performed by intention to treat. This trial is registered with ClinicalTrials.gov (No. NCT00693199).

RESULTS At day 28 of the trial, the Amlodipine Plus terazosin group demonstrated comparable efficacy in lowering the total International Prostate Symptom Score and significant improvement in the presence of overactive bladder compared with the terazosin group (P < .05) and significant improvement in quality of life compared with the Amlodipine group (P < .05). The Amlodipine plus terazosin group also achieved the greatest blood pressure control compared with either the terazosin group (P < .01) or Amlodipine group (P < .05). All 3 treatment regimens were well tolerated by the study patients.

CONCLUSIONS The results of this 4-week, double-blind, randomized trial have demonstrated that in Chinese male hypertensive patients with LUTS, low-dose Amlodipine plus terazosin therapy appears to be a safe and effective combination therapy to control both conditions, especially for those with predominant overactive bladder symptoms. UROLOGY 74: 130-136, 2009. (c) 2009 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000267802100030
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65470
专题北京大学第一临床医学院_泌尿外科
作者单位1.Peking Univ, Dept Urol, Hosp 1, Beijing 100871, Peoples R China
2.Anhui Med Univ, Inst Biomed, Hefei, Anhui, Peoples R China
3.Univ Illinois, Sch Publ Hlth, Chicago, IL 60612 USA
4.Univ Sci & Technol China, Sch Life Sci, Hefei 230026, Anhui, Peoples R China
5.Wenzhou Med Coll, Sch Publ Hlth, Wenzhou, Zhejiang, Peoples R China
6.Acad Mil Med Sci China, Dept Clin Pharmacol, Affiliated Hosp 1, Beijing, Peoples R China
7.Northwestern Univ, Childrens Mem Hosp, Feinberg Sch Med, Mary Ann & J Milburn Smith Child Hlth Res Program, Chicago, IL 60614 USA
8.Northwestern Univ, Childrens Mem Res Ctr, Feinberg Sch Med, Chicago, IL 60614 USA
推荐引用方式
GB/T 7714
Liu, Haipeng,Liu, Ping,Mao, Guangyun,et al. Efficacy of Combined Amlodipine/Terazosin Therapy in Male Hypertensive Patients With Lower Urinary Tract Symptoms: A Randomized, Double-blind Clinical Trial[J]. UROLOGY,2009,74(1):130-136.
APA Liu, Haipeng.,Liu, Ping.,Mao, Guangyun.,Chen, Guangliang.,Wang, Binyan.,...&Xu, Xiping.(2009).Efficacy of Combined Amlodipine/Terazosin Therapy in Male Hypertensive Patients With Lower Urinary Tract Symptoms: A Randomized, Double-blind Clinical Trial.UROLOGY,74(1),130-136.
MLA Liu, Haipeng,et al."Efficacy of Combined Amlodipine/Terazosin Therapy in Male Hypertensive Patients With Lower Urinary Tract Symptoms: A Randomized, Double-blind Clinical Trial".UROLOGY 74.1(2009):130-136.
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