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学科主题: 临床医学
题名:
Efficacy of imatinib dose escalation in Chinese gastrointestinal stromal tumor patients
作者: Li, Jian; Gong, Ji-Fang; Li, Jie; Gao, Jing; Sun, Nai-Ping; Shen, Lin
关键词: Gene mutation ; Gastrointestinal stromal tumor ; Imatinib ; Increased dose
刊名: WORLD JOURNAL OF GASTROENTEROLOGY
发表日期: 2012-02-21
DOI: 10.3748/wjg.v18.i7.698
卷: 18, 期:7, 页:698-703
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Gastroenterology & Hepatology
研究领域[WOS]: Gastroenterology & Hepatology
关键词[WOS]: MESYLATE ; PROGRESSION ; SAFETY ; KINASE ; TRIAL
英文摘要:

AIM: To investigate the efficacy and safety of imatinib dose escalation in Chinese patients with advanced gastrointestinal stromal tumor (GIST).

METHODS: Advanced GIST patients previously failing 400 mg imatinib treatment were enrolled in this study. Patients received imatinib with dose escalation to 600 mg/d, and further dose escalation to 800 mg/d if imatinib 600 mg/d failed. Progression-free survival, overall survival, clinical efficacy, c-kit/PDGFRA genotype and safety were evaluated.

RESULTS: 52 patients were enrolled in this study. For the 47 evaluable patients receiving imatinib (600 mg/d), the disease control rate was 40.4%, and the median progression-free survival for all patients was 17 wk (95% CI: 3.9-30.1). The median overall survival after dose escalation was 81 wk (95% CI: 36.2-125.8). Adverse events, mainly edema, fatigue, granulocytopenia and skin rash were tolerable. However, further dose escalation (800 mg/d) in 14 cases was ineffective, with disease progression and severe adverse events. Among 30 cases examined for gene mutations, patients with exon 9 mutations experienced a better progression-free survival of 47 wk.

CONCLUSION: Imatinib dose escalation to 600 mg/d is more appropriate for Chinese patients and may achieve further survival benefit. (C) 2012 Baishideng. All rights reserved.

语种: 英语
所属项目编号: 08-17
项目资助者: Beijing Cancer Hospital Foundation ; Novartis Oncology
WOS记录号: WOS:000300600900015
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65474
Appears in Collections:北京大学临床肿瘤学院_期刊论文

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作者单位: Peking Univ, Beijing Canc Hosp & Inst, Sch Oncol, Dept GI Oncol,Minist Natl Educ,Lab Carcinogenesis, Beijing 100142, Peoples R China

Recommended Citation:
Li, Jian,Gong, Ji-Fang,Li, Jie,et al. Efficacy of imatinib dose escalation in Chinese gastrointestinal stromal tumor patients[J]. WORLD JOURNAL OF GASTROENTEROLOGY,2012,18(7):698-703.
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