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学科主题: 口腔医学
题名:
Topography-dependent antibacterial, osteogenic and anti-aging properties of pure titanium
作者: Luo, Qiaojie1; Huang, Ying1,2; Zha, Guangyu1; Chen, Yadong1; Deng, Xuliang2; Zhang, Kai1; Zhu, Weipu3; Zhao, Shifang1; Li, Xiaodong1
刊名: JOURNAL OF MATERIALS CHEMISTRY B
发表日期: 2015
DOI: 10.1039/c4tb01556h
卷: 3, 期:5, 页:784-795
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Materials Science, Biomaterials
研究领域[WOS]: Materials Science
关键词[WOS]: SURFACE-FREE ENERGY ; BACTERIAL ADHESION ; PROTEIN ADSORPTION ; IMPLANT SURFACES ; BONE APPOSITION ; CELLS ; OSSEOINTEGRATION ; OSTEOBLASTS ; SUBSTRATE ; POLYMERS
英文摘要:

After nearly half a century of development under the guidance of the osseointegration theory, the major dilemmas for current implant dentistry are the implant associated infection and insufficient osseointegration. Moreover, biological aging of titanium (Ti) implants also brings great uncertainty to clinical results. In the present study, a novel nano-micro-hierarchical topography pattern is created by sandblasting and dual acid-etching on a Ti surface. The physico-chemical properties of the surfaces were characterized by scanning electron microscopy, contact angle measurement, X-ray photoelectron spectroscopy and X-ray diffraction. The effects of the hierarchical surfaces on osteoprogenitor cell growth and bacterial activities were separately evaluated. The optimized nano-micro-hierarchical Ti surface exhibits surprisingly topography-dependent antibacterial capacity via inhibiting bacterial adhesion of several species in the early stage and better osteogenesis ability than the microscaled surface. Aging studies demonstrate that, compared with the surface with a microscale structure, the nano-micro-hierarchical Ti surface has greater anti-aging ability manifested as being more capable to retain hydrophilicity and bioactivity during aging. Furthermore, the present study reveals that the biological aging of the Ti implant is attributed to two decisive factors during the aging period: the progressively thickened amorphous TiO2 layer by autoxidation and the unavoidable accumulation of hydrocarbons on the Ti implant surface.

语种: 英语
所属项目编号: 51173163 ; 81400563 ; 2012BAI07B01 ; 2012CB933900 ; 2012QNA7043
项目资助者: National Natural Science Foundation of China ; National Science-Technology Support Plan Project of China ; National Basic Research Program of China ; Fundamental Research Funds for the Central Universities
WOS记录号: WOS:000348198700011
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65475
Appears in Collections:北京大学口腔医学院_期刊论文

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作者单位: 1.Zhejiang Univ, Coll Med, Affiliated Stomatol Hosp, Hangzhou 310003, Zhejiang, Peoples R China
2.Peking Univ, Sch & Hosp Stomatol, Dept Geriatr Dent, Beijing 100871, Peoples R China
3.Zhejiang Univ, Dept Polymer Sci & Engn, CMOE Key Lab Macromol Synth & Functionalizat, Hangzhou 310003, Zhejiang, Peoples R China

Recommended Citation:
Luo, Qiaojie,Huang, Ying,Zha, Guangyu,et al. Topography-dependent antibacterial, osteogenic and anti-aging properties of pure titanium[J]. JOURNAL OF MATERIALS CHEMISTRY B,2015,3(5):784-795.
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