IR@PKUHSC  > 北京大学口腔医学院
学科主题口腔医学
Topography-dependent antibacterial, osteogenic and anti-aging properties of pure titanium
Luo, Qiaojie1; Huang, Ying1,2; Zha, Guangyu1; Chen, Yadong1; Deng, Xuliang2; Zhang, Kai1; Zhu, Weipu3; Zhao, Shifang1; Li, Xiaodong1
刊名JOURNAL OF MATERIALS CHEMISTRY B
2015
DOI10.1039/c4tb01556h
3期:5页:784-795
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Materials Science, Biomaterials
研究领域[WOS]Materials Science
关键词[WOS]SURFACE-FREE ENERGY ; BACTERIAL ADHESION ; PROTEIN ADSORPTION ; IMPLANT SURFACES ; BONE APPOSITION ; CELLS ; OSSEOINTEGRATION ; OSTEOBLASTS ; SUBSTRATE ; POLYMERS
英文摘要

After nearly half a century of development under the guidance of the osseointegration theory, the major dilemmas for current implant dentistry are the implant associated infection and insufficient osseointegration. Moreover, biological aging of titanium (Ti) implants also brings great uncertainty to clinical results. In the present study, a novel nano-micro-hierarchical topography pattern is created by sandblasting and dual acid-etching on a Ti surface. The physico-chemical properties of the surfaces were characterized by scanning electron microscopy, contact angle measurement, X-ray photoelectron spectroscopy and X-ray diffraction. The effects of the hierarchical surfaces on osteoprogenitor cell growth and bacterial activities were separately evaluated. The optimized nano-micro-hierarchical Ti surface exhibits surprisingly topography-dependent antibacterial capacity via inhibiting bacterial adhesion of several species in the early stage and better osteogenesis ability than the microscaled surface. Aging studies demonstrate that, compared with the surface with a microscale structure, the nano-micro-hierarchical Ti surface has greater anti-aging ability manifested as being more capable to retain hydrophilicity and bioactivity during aging. Furthermore, the present study reveals that the biological aging of the Ti implant is attributed to two decisive factors during the aging period: the progressively thickened amorphous TiO2 layer by autoxidation and the unavoidable accumulation of hydrocarbons on the Ti implant surface.

语种英语
WOS记录号WOS:000348198700011
项目编号51173163 ; 81400563 ; 2012BAI07B01 ; 2012CB933900 ; 2012QNA7043
资助机构National Natural Science Foundation of China ; National Science-Technology Support Plan Project of China ; National Basic Research Program of China ; Fundamental Research Funds for the Central Universities
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65475
专题北京大学口腔医学院
北京大学口腔医学院_特诊科
作者单位1.Zhejiang Univ, Coll Med, Affiliated Stomatol Hosp, Hangzhou 310003, Zhejiang, Peoples R China
2.Peking Univ, Sch & Hosp Stomatol, Dept Geriatr Dent, Beijing 100871, Peoples R China
3.Zhejiang Univ, Dept Polymer Sci & Engn, CMOE Key Lab Macromol Synth & Functionalizat, Hangzhou 310003, Zhejiang, Peoples R China
推荐引用方式
GB/T 7714
Luo, Qiaojie,Huang, Ying,Zha, Guangyu,et al. Topography-dependent antibacterial, osteogenic and anti-aging properties of pure titanium[J]. JOURNAL OF MATERIALS CHEMISTRY B,2015,3(5):784-795.
APA Luo, Qiaojie.,Huang, Ying.,Zha, Guangyu.,Chen, Yadong.,Deng, Xuliang.,...&Li, Xiaodong.(2015).Topography-dependent antibacterial, osteogenic and anti-aging properties of pure titanium.JOURNAL OF MATERIALS CHEMISTRY B,3(5),784-795.
MLA Luo, Qiaojie,et al."Topography-dependent antibacterial, osteogenic and anti-aging properties of pure titanium".JOURNAL OF MATERIALS CHEMISTRY B 3.5(2015):784-795.
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