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Histone deacetylase 6 activity is critical for the metastasis of Burkitt s lymphoma cells
Ding, Ning; Ping, Lingyan; Feng, Lixia; Zheng, Xiaohui; Song, Yuqin; Zhu, Jun
关键词Burkitt s lymphoma histone deacetylase 6 Cell shape elongation Metastasis Microtubule dynamics
刊名CANCER CELL INTERNATIONAL
2014-12-05
DOI10.1186/s12935-014-0139-z
14
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]HDAC6 ; INHIBITORS ; MICROTUBULES ; ACETYLATION ; MOTILITY ; PROTEIN ; CANCER ; P53
英文摘要

Background: Burkitt s lymphoma is an aggressive malignancy with high risk of metastasis to extranodal sites, such as bone marrow and central nervous system. The prognosis of metastatic Burkitt s lymphoma is poor. Here we sought to identify a role of histone deacetylase 6 (HDAC6) in the metastasis of Burkitt s lymphoma cells.

Methods: Burkitt s lymphoma cells were pharmacologically treated with niltubacin, tubacin or sodium butyrate (NaB) or transfected with siRNAs to knock down the expression of HDAC6. Cell migration and invasion ability were measured by transwell assay, and cell cycle progression was analyzed by flow cytometry. Cell adhesion and proliferation was determined by CellTiter-Glo luminescent cell viability assay kit. Cell morphological alteration and microtubule stability were analyzed by immunofluorescence staining. Effect of niltubacin, tubacin and NaB on acetylated tubulin and siRNA efficacy were measured by western blotting.

Results: Suppression of histone deacetylase 6 activity significantly compromised the migration and invasion of Burkitt s lymphoma cells, without affecting cell proliferation and cell cycle progression. Mechanistic study revealed that HDAC6 modulated chemokine induced cell shape elongation and cell adhesion probably through its action on microtubule dynamics.

Conclusions: We identified a critical role of HDAC6 in the metastasis of Burkitt s lymphoma cells, suggesting that pharmacological inhibition of HDAC6 could be a promising strategy for the management of metastatic Burkitt s lymphoma.

语种英语
WOS记录号WOS:000364238700001
项目编号81201873 ; 81470368 ; 7132050 ; 2011CB504303
资助机构NSFC ; Beijing Natural Science Foundation ; 973 program
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65478
专题北京大学临床肿瘤学院_淋巴肿瘤内科
作者单位Peking Univ, Canc Hosp & Inst, Dept Lymphoma, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100142, Peoples R China
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GB/T 7714
Ding, Ning,Ping, Lingyan,Feng, Lixia,et al. Histone deacetylase 6 activity is critical for the metastasis of Burkitt s lymphoma cells[J]. CANCER CELL INTERNATIONAL,2014,14.
APA Ding, Ning,Ping, Lingyan,Feng, Lixia,Zheng, Xiaohui,Song, Yuqin,&Zhu, Jun.(2014).Histone deacetylase 6 activity is critical for the metastasis of Burkitt s lymphoma cells.CANCER CELL INTERNATIONAL,14.
MLA Ding, Ning,et al."Histone deacetylase 6 activity is critical for the metastasis of Burkitt s lymphoma cells".CANCER CELL INTERNATIONAL 14(2014).
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