IR@PKUHSC  > 北京大学基础医学院
学科主题临床医学
Hepatocellular Carcinoma Recurrence is an independent Risk Factor for HB Recurrence After Liver Transplantation
Gao, Peng-ji; Gao, Jie; Li, Zhao; Hu, Zhi-ping; Zhu, Ji-ye
关键词Jiver transplantation hepatocellular carcinoma recurrence hepatitis B recurrence
刊名HEPATO-GASTROENTEROLOGY
2014-09-01
DOI10.5754/hge14454
61期:134页:1523-1528
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Gastroenterology & Hepatology ; Surgery
研究领域[WOS]Gastroenterology & Hepatology ; Surgery
关键词[WOS]CHRONIC HEPATITIS-B ; VIRUS RECURRENCE ; LAMIVUDINE ; RECIPIENTS ; DISEASE ; HBSAG
英文摘要

Background/Aims: To confirm the relationship between hepatitis B recurrence and Hepatocellular caricinoma recurrence. Methodology: Data from 340 patients undergoing liver transplantation for HBV-related liver disease were retrospectively evaluated. Clinically relevant variables were analyzed using univariate models. Significant variables were subjected to multivariate logistic regression analysis to identify the independent predictors for HBV recurrence. Fifteen samples removed from HCC recurrence patients were stained for HBsAg and HBcAg. Results: The analyzed population included 283 male and 57 female patients. The mean age was 48.5 +/- 19.33 years and median follow-up was 47 months. Hepatitis B relapsed in 16 patients (4.7%). Univariate analysis indicated that HCC (p=0.0222) and HCC recurrence (P=0.000) were associated to post transplantation HB. Multivariate analysis identified HCC recurrence as an independent risk factor for HB recurrence (hazard ratio: 23.2262 (95% CI: 3.752, 144.216); P < 0.001). Three of 15 metastatic lesions were positive for HBsAg and 1 lesion was positive for HBcAg. Conclusion: HCC recirremce is an independent risk factor for post transplantation recurrence of hepatitis.

语种英语
WOS记录号WOS:000341170900008
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65479
专题北京大学基础医学院
北京大学第二临床医学院_肝胆外科
作者单位Peking Univ, Peoples Hosp, Dept Hepatobiliary Surg, Beijing 100044, Peoples R China
推荐引用方式
GB/T 7714
Gao, Peng-ji,Gao, Jie,Li, Zhao,et al. Hepatocellular Carcinoma Recurrence is an independent Risk Factor for HB Recurrence After Liver Transplantation[J]. HEPATO-GASTROENTEROLOGY,2014,61(134):1523-1528.
APA Gao, Peng-ji,Gao, Jie,Li, Zhao,Hu, Zhi-ping,&Zhu, Ji-ye.(2014).Hepatocellular Carcinoma Recurrence is an independent Risk Factor for HB Recurrence After Liver Transplantation.HEPATO-GASTROENTEROLOGY,61(134),1523-1528.
MLA Gao, Peng-ji,et al."Hepatocellular Carcinoma Recurrence is an independent Risk Factor for HB Recurrence After Liver Transplantation".HEPATO-GASTROENTEROLOGY 61.134(2014):1523-1528.
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