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IR@PKUHSC  > 北京大学第二临床医学院  > 肝胆外科  > 期刊论文
学科主题: 临床医学
题名:
Hepatocellular Carcinoma Recurrence is an independent Risk Factor for HB Recurrence After Liver Transplantation
作者: Gao, Peng-ji; Gao, Jie; Li, Zhao; Hu, Zhi-ping; Zhu, Ji-ye
关键词: Jiver transplantation ; hepatocellular carcinoma recurrence ; hepatitis B recurrence
刊名: HEPATO-GASTROENTEROLOGY
发表日期: 2014-09-01
DOI: 10.5754/hge14454
卷: 61, 期:134, 页:1523-1528
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Gastroenterology & Hepatology ; Surgery
研究领域[WOS]: Gastroenterology & Hepatology ; Surgery
关键词[WOS]: CHRONIC HEPATITIS-B ; VIRUS RECURRENCE ; LAMIVUDINE ; RECIPIENTS ; DISEASE ; HBSAG
英文摘要:

Background/Aims: To confirm the relationship between hepatitis B recurrence and Hepatocellular caricinoma recurrence. Methodology: Data from 340 patients undergoing liver transplantation for HBV-related liver disease were retrospectively evaluated. Clinically relevant variables were analyzed using univariate models. Significant variables were subjected to multivariate logistic regression analysis to identify the independent predictors for HBV recurrence. Fifteen samples removed from HCC recurrence patients were stained for HBsAg and HBcAg. Results: The analyzed population included 283 male and 57 female patients. The mean age was 48.5 +/- 19.33 years and median follow-up was 47 months. Hepatitis B relapsed in 16 patients (4.7%). Univariate analysis indicated that HCC (p=0.0222) and HCC recurrence (P=0.000) were associated to post transplantation HB. Multivariate analysis identified HCC recurrence as an independent risk factor for HB recurrence (hazard ratio: 23.2262 (95% CI: 3.752, 144.216); P < 0.001). Three of 15 metastatic lesions were positive for HBsAg and 1 lesion was positive for HBcAg. Conclusion: HCC recirremce is an independent risk factor for post transplantation recurrence of hepatitis.

语种: 英语
WOS记录号: WOS:000341170900008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65479
Appears in Collections:北京大学第二临床医学院_肝胆外科_期刊论文

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作者单位: Peking Univ, Peoples Hosp, Dept Hepatobiliary Surg, Beijing 100044, Peoples R China

Recommended Citation:
Gao, Peng-ji,Gao, Jie,Li, Zhao,et al. Hepatocellular Carcinoma Recurrence is an independent Risk Factor for HB Recurrence After Liver Transplantation[J]. HEPATO-GASTROENTEROLOGY,2014,61(134):1523-1528.
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