IR@PKUHSC  > 北京大学基础医学院  > 生物物理学系
学科主题基础医学
Effect of Co-60 irradiation on characteristics of hemorheology in rabbits
Wen, ZY; Xie, LD; Yan, ZY; Yao, WJ; Chen, K; Ka, WB; Chien, S
关键词Co-60 irradiation rabbit hemorheological characteristics
刊名CLINICAL HEMORHEOLOGY AND MICROCIRCULATION
2001
25期:2页:75-81
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Hematology ; Peripheral Vascular Disease
研究领域[WOS]Hematology ; Cardiovascular System & Cardiology
关键词[WOS]HEMATOPOIETIC RECONSTITUTION ; RADIATION ; APLASIA ; CHARGE ; MICE ; PIG
英文摘要

A high-dose (7 Gy) whole-body Co-60 irradiation for a short period caused disturbances of hematopoietic function. A decrease in the hematocrit of the circulating blood lasted for about 15 days, thus forming an anemic animal model. We studied the influence of high-dose Co-60 irradiation on hemorheologic parameters: percentage of reticulocytes, RBC deformability, sedimentation rate and plasma fibrinogen concentration in the rabbit. It was found that the plasma fibrinogen concentration increased to twice more than control level and that percentage of reticulocytes in circulation disappeared immediately after irradiation. The deformation index of RBCs in shear flow decreased from a value of 58% down to a value of 42% in the first two weeks and gradually returned to control levels about 40 days after Co-60 irradiation. Our results showed that a short period of high-dose Co-60 irradiation caused severe and relatively long-lasting damage of hematopoietic system in animals′ body.

语种英语
WOS记录号WOS:000172671900006
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65480
专题北京大学基础医学院_生物物理学系
作者单位1.Peking Univ, Sch Basic Med Sci, Dept Biophys, Hemorheol Ctr, Beijing 100083, Peoples R China
2.Peking Univ, Dept Engn Sci & Mech, Beijing 100871, Peoples R China
3.Univ Calif San Diego, Dept Bioengn, La Jolla, CA 92093 USA
4.Univ Calif San Diego, Whitaker Inst Biomed Engn, La Jolla, CA 92093 USA
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GB/T 7714
Wen, ZY,Xie, LD,Yan, ZY,et al. Effect of Co-60 irradiation on characteristics of hemorheology in rabbits[J]. CLINICAL HEMORHEOLOGY AND MICROCIRCULATION,2001,25(2):75-81.
APA Wen, ZY.,Xie, LD.,Yan, ZY.,Yao, WJ.,Chen, K.,...&Chien, S.(2001).Effect of Co-60 irradiation on characteristics of hemorheology in rabbits.CLINICAL HEMORHEOLOGY AND MICROCIRCULATION,25(2),75-81.
MLA Wen, ZY,et al."Effect of Co-60 irradiation on characteristics of hemorheology in rabbits".CLINICAL HEMORHEOLOGY AND MICROCIRCULATION 25.2(2001):75-81.
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