|Erythrocytic Hydrogen Sulfide Production Is Increased in Children with Vasovagal Syncope|
|Yang, Jinyan1; Li, Hongxia1; Ochs, Todd2; Zhao, Juan1; Zhang, Qingyou1; Du, Shuxu3; Chen, Yonghong1; Liu, Ping1; Wang, Yuli1; Feng, Xueli1; Zhang, Chunyu1; Tang, Chaoshu4; Du, Junbao1,5; Jin, Hongfang1|
|刊名||JOURNAL OF PEDIATRICS|
|WOS标题词||Science & Technology|
|关键词[WOS]||HEAD-UP TILT ; NEUROCARDIOGENIC SYNCOPE ; TACHYCARDIA SYNDROME ; DIAGNOSIS ; HYPERTENSION ; MANAGEMENT ; PATHWAY ; H2S|
Objectives To explore the differences in erythrocyte hydrogen sulfide (H2S) production in children with vasovagal syncope (VVS).
Study design A total of 54 children including 27 with VVS, aged 6-16 years (mean age 11.3 +/- 3.3 years), and 27 healthy children, aged 3-17 years (mean age 10.4 +/- 1.8 years) were included in the study. Children with VVS had symptoms of dizziness, pallor, blurred vision, nausea, and some had syncope. Erythrocyte H2S production was measured by a sulphur-sensitive electrode. Flow-mediated dilation (FMD) of brachial artery was measured for each patient by vascular ultrasound.
Results H2S production from erythrocytes was significantly increased in the children with VVS compared with controls (P < .01). The erythrocytic H2S production in the VVS-vasoinhibitory subgroup was obviously higher than that in VVS-cardioinhibitory (P < .05) and VVS-mixed inhibitory subgroups (P < .05). FMD in the VVS-vasoinhibitory subgroup was greater than that in the VVS-cardioinhibitory (P < .05) and the VVS- mixed subgroups (P < .05). The erythrocytic H2S production had a positive linear correlation with FMD in children with VVS (P < .05).
Conclusions Increased erythrocyte H2S production may be involved in the pathogenesis of VVS in children.
|项目编号||2013CB933801 ; 2011CB503904 ; 2012BAI03B03 ; NCET-11-0005|
|资助机构||Major Basic Research Project of China ; National Twelfth Five-Year Plan for Science & ; Technology Support ; Program for New Century Talent of Ministry of Education of China|
|作者单位||1.Childrens Hosp, Feinberg Sch Med, Chicago, IL USA|
2.Minist Educ, Key Lab Cardiovasc Sci, Beijing, Peoples R China
3.Peking Univ, Hosp 1, Dept Pediat, Beijing 100034, Peoples R China
4.Capital Med Univ, Dept Pediat, Shijitan Hosp, Beijing, Peoples R China
5.Peking Univ, Ctr Hlth Sci, Dept Physiol & Pathophysiol, Beijing 100034, Peoples R China
|Yang, Jinyan,Li, Hongxia,Ochs, Todd,et al. Erythrocytic Hydrogen Sulfide Production Is Increased in Children with Vasovagal Syncope[J]. JOURNAL OF PEDIATRICS,2015,166(4):965-969.|
|APA||Yang, Jinyan.,Li, Hongxia.,Ochs, Todd.,Zhao, Juan.,Zhang, Qingyou.,...&Jin, Hongfang.(2015).Erythrocytic Hydrogen Sulfide Production Is Increased in Children with Vasovagal Syncope.JOURNAL OF PEDIATRICS,166(4),965-969.|
|MLA||Yang, Jinyan,et al."Erythrocytic Hydrogen Sulfide Production Is Increased in Children with Vasovagal Syncope".JOURNAL OF PEDIATRICS 166.4(2015):965-969.|