IR@PKUHSC  > 北京大学第一临床医学院  > 儿科
学科主题临床医学
Erythrocytic Hydrogen Sulfide Production Is Increased in Children with Vasovagal Syncope
Yang, Jinyan1; Li, Hongxia1; Ochs, Todd2; Zhao, Juan1; Zhang, Qingyou1; Du, Shuxu3; Chen, Yonghong1; Liu, Ping1; Wang, Yuli1; Feng, Xueli1; Zhang, Chunyu1; Tang, Chaoshu4; Du, Junbao1,5; Jin, Hongfang1
刊名JOURNAL OF PEDIATRICS
2015-04-01
DOI10.1016/j.jpeds.2014.12.021
166期:4页:965-969
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pediatrics
研究领域[WOS]Pediatrics
关键词[WOS]HEAD-UP TILT ; NEUROCARDIOGENIC SYNCOPE ; TACHYCARDIA SYNDROME ; DIAGNOSIS ; HYPERTENSION ; MANAGEMENT ; PATHWAY ; H2S
英文摘要

Objectives To explore the differences in erythrocyte hydrogen sulfide (H2S) production in children with vasovagal syncope (VVS).

Study design A total of 54 children including 27 with VVS, aged 6-16 years (mean age 11.3 +/- 3.3 years), and 27 healthy children, aged 3-17 years (mean age 10.4 +/- 1.8 years) were included in the study. Children with VVS had symptoms of dizziness, pallor, blurred vision, nausea, and some had syncope. Erythrocyte H2S production was measured by a sulphur-sensitive electrode. Flow-mediated dilation (FMD) of brachial artery was measured for each patient by vascular ultrasound.

Results H2S production from erythrocytes was significantly increased in the children with VVS compared with controls (P < .01). The erythrocytic H2S production in the VVS-vasoinhibitory subgroup was obviously higher than that in VVS-cardioinhibitory (P < .05) and VVS-mixed inhibitory subgroups (P < .05). FMD in the VVS-vasoinhibitory subgroup was greater than that in the VVS-cardioinhibitory (P < .05) and the VVS- mixed subgroups (P < .05). The erythrocytic H2S production had a positive linear correlation with FMD in children with VVS (P < .05).

Conclusions Increased erythrocyte H2S production may be involved in the pathogenesis of VVS in children.

语种英语
WOS记录号WOS:000353385700035
项目编号2013CB933801 ; 2011CB503904 ; 2012BAI03B03 ; NCET-11-0005
资助机构Major Basic Research Project of China ; National Twelfth Five-Year Plan for Science &amp ; Technology Support ; Program for New Century Talent of Ministry of Education of China
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65487
专题北京大学第一临床医学院_儿科
作者单位1.Childrens Hosp, Feinberg Sch Med, Chicago, IL USA
2.Minist Educ, Key Lab Cardiovasc Sci, Beijing, Peoples R China
3.Peking Univ, Hosp 1, Dept Pediat, Beijing 100034, Peoples R China
4.Capital Med Univ, Dept Pediat, Shijitan Hosp, Beijing, Peoples R China
5.Peking Univ, Ctr Hlth Sci, Dept Physiol & Pathophysiol, Beijing 100034, Peoples R China
推荐引用方式
GB/T 7714
Yang, Jinyan,Li, Hongxia,Ochs, Todd,et al. Erythrocytic Hydrogen Sulfide Production Is Increased in Children with Vasovagal Syncope[J]. JOURNAL OF PEDIATRICS,2015,166(4):965-969.
APA Yang, Jinyan.,Li, Hongxia.,Ochs, Todd.,Zhao, Juan.,Zhang, Qingyou.,...&Jin, Hongfang.(2015).Erythrocytic Hydrogen Sulfide Production Is Increased in Children with Vasovagal Syncope.JOURNAL OF PEDIATRICS,166(4),965-969.
MLA Yang, Jinyan,et al."Erythrocytic Hydrogen Sulfide Production Is Increased in Children with Vasovagal Syncope".JOURNAL OF PEDIATRICS 166.4(2015):965-969.
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