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学科主题: 临床医学
题名:
Less disease severity and favorable prognosis are associated with postmenopausal systemic lupus erythematosus patients
作者: Deng, Xiao Li; Liu, Xiang Yuan
关键词: Systemic lupus erythematosus ; Postmenopause onset
刊名: RHEUMATOLOGY INTERNATIONAL
发表日期: 2009-03-01
DOI: 10.1007/s00296-008-0724-3
卷: 29, 期:5, 页:535-538
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Rheumatology
研究领域[WOS]: Rheumatology
关键词[WOS]: BLOOD MONONUCLEAR-CELLS
英文摘要:

The aim of this study is to characterize the clinical manifestations of postmenopausal systemic lupus erythematosus (SLE) patients. Of the 699 SLE inpatients, 20 postmenopausal and 70 menstruous SLE patients were evaluated and compared for the clinical manifestations. The mean age of onset was 55.05 years (range from 42 to 66) with a peak of 50-60 in postmenopausal lupus patients. The average time from SLE onset to diagnosis was 2.18 years. Arthritis was the most frequent initial manifestation in the postmenopausal group. Other common clinical manifestations and laboratory abnormalities include lassitude, fever, alopecia, malar rash, cardiac impairment and weight loss, and elevated ESR, decreased C3, ANA a parts per thousand yen 1:80, hypergammaglobulinemia and anti-RNP antibody positive. Compared with menstruous lupus patients, postmenopausal patients were more likely to have weight loss (P < 0.01), myalgia and myasthenia (P < 0.01), and less likely to have malar rash (P < 0.05), renal involvement (P < 0.01), leukocytopenia (P < 0.05) and positive ANA (P < 0.01). Thus, less disease severity and favorable prognosis were associated with postmenopausal SLE patients. Misdiagnosis and missed diagnosis were easy to make with their non-specific symptoms with fewer features suggestive of diagnosis.

语种: 英语
WOS记录号: WOS:000263781500008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65493
Appears in Collections:北京大学第三临床医学院_期刊论文

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作者单位: Peking Univ, Dept Rheumatol & Immunol, Hosp 3, Beijing 100871, Peoples R China

Recommended Citation:
Deng, Xiao Li,Liu, Xiang Yuan. Less disease severity and favorable prognosis are associated with postmenopausal systemic lupus erythematosus patients[J]. RHEUMATOLOGY INTERNATIONAL,2009,29(5):535-538.
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