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学科主题临床医学
Intracranial aneurysms in adolescents
Liang, Jian-tao1,2,3; Huo, Li-rong4; Bao, Yu-hai2,3; Zhang, Hong-qi2,3; Wang, Zhen-yu1; Ling, Feng2,3
关键词Adolescent Aneurysm Intracranial Microsurgery
刊名CHILDS NERVOUS SYSTEM
2011-07-01
DOI10.1007/s00381-010-1334-4
27期:7页:1101-1107
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Clinical Neurology ; Pediatrics ; Surgery
研究领域[WOS]Neurosciences & Neurology ; Pediatrics ; Surgery
关键词[WOS]INTRA-CRANICAL ANEURYSMS ; CEREBRAL ANEURYSMS ; CAROTID-ARTERY ; CHILDHOOD ; CHILDREN ; BYPASS ; POPULATION ; EXPERIENCE ; GRAFT
英文摘要

Intracranial aneurysms are extremely uncommon in adolescents. This study was undertaken to assess the clinical and radiological characteristics and clarify the choice of therapeutic strategies of intracranial aneurysms in adolescents with age range from 15 to 18 years.

From our dedicated aneurysmal databank between October 1985 and July 2008, we reviewed 16 consecutive adolescents who had 20 intracranial aneurysms.

Ten boys and six girls (male/female ratio = 1.67:1; mean age 16.78 +/- 1.18 years) were included in the present study. Intracranial aneurysms in adolescents constituted 0.91% of all intracranial aneurysms. It was found that 25% of the lesions were in the posterior circulation, while 75% of the lesions were in the anterior circulation, and 25% developed on the middle cerebral artery (MCA). Half of the patients presented with subarachnoid hemorrhage and others mainly presented with mass effect such as weakness in the extremities, diplopia, and dysfunction of eye movement. Eight cases underwent endovascular treatment: including GDC therapy in five patients, parental artery occlusion in two patients, and cover stent implantation in one patient with pseudoaneurysm of the cavernous segment of the left internal carotid artery. Four patients received microsurgical therapy: aneurismal neck clipping for two patients and extracranial-intracranial (EC-IC) bypass and trapping of complex aneurysms in MCA for the other two patients. Four patients did not receive microsurgical or endovascular therapy, including a boy whose aneurysm spontaneously thrombosed preoperatively and a girl who died before operation because of rerupture of aneurysm. Two patients did not undergo therapy owing to the high operative risk. All of the patients who received therapy had favorable outcome (GOS 4 or 5) at discharge and at follow-up.

Intracranial aneurysms in adolescents differ from those in adults in many ways including the following: male predominance; high incidence of large or giant, traumatic, dissecting, and fusiform aneurysms; high incidence of aneurysms in the posterior circulation; high incidence of spontaneous thrombosis; better Hunt-Hess grade at presentation; and better therapeutic outcome. Both microsurgical approaches and endovascular treatment were effective. For some giant, complex intracranial aneurysms, parent artery occlusion or EC-IC bypass is the best treatment choice.

语种英语
WOS记录号WOS:000291480300011
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65497
专题北京大学第三临床医学院_神经外科
北京大学医学部管理机构_北京大学医学部校医院
作者单位1.Peking Univ, Hosp 3, Dept Neurosurg, Beijing 100191, Peoples R China
2.Capital Med Univ, Dept Neurosurg, Xuanwu Hosp, Beijing 100053, Peoples R China
3.Cerebrovasc Dis Res Inst, Beijing 100053, Peoples R China
4.Capital Med Univ, Minist Educ, Key Lab Neurodegenerat Disorders, Beijing 100069, Peoples R China
推荐引用方式
GB/T 7714
Liang, Jian-tao,Huo, Li-rong,Bao, Yu-hai,et al. Intracranial aneurysms in adolescents[J]. CHILDS NERVOUS SYSTEM,2011,27(7):1101-1107.
APA Liang, Jian-tao,Huo, Li-rong,Bao, Yu-hai,Zhang, Hong-qi,Wang, Zhen-yu,&Ling, Feng.(2011).Intracranial aneurysms in adolescents.CHILDS NERVOUS SYSTEM,27(7),1101-1107.
MLA Liang, Jian-tao,et al."Intracranial aneurysms in adolescents".CHILDS NERVOUS SYSTEM 27.7(2011):1101-1107.
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