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学科主题基础医学
Structural and functional analysis of natrin, a venom protein that targets various ion channels
Wang, Feng; Li, He; Liu, Ming-na; Song, Hui; Han, Hong-mei; Wang, Qiong-ling; Yin, Chang-chen; Zhou, Yuan-cong; Qi, Zhi; Shu, Yu-yan; Lin, Zheng-jiong; Jiang, Tao
关键词CRISP natrin crystal structure blocker ion channel
刊名BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
2006-12-15
DOI10.1016/j.bbrc.2006.10.067
351期:2页:443-448
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]RICH SECRETORY PROTEIN ; CRYSTAL-STRUCTURE ; CRISP FAMILY ; POTASSIUM CHANNELS ; K+ CHANNEL ; CYSTEINE-RICH-SECRETORY-PROTEIN-4 CRISP4 ; LIZARD VENOM ; SNAKE-VENOM ; TOXIN ; HELOTHERMINE
英文摘要

Cysteine-rich secretory proteins (CRISPs) are secreted single-chain proteins found in different sources. Natrin is a member of the CRISP family purified from the snake venom of Naja naja atra, which has been reported as a BKca channel blocker. In our study, crystals of natrin were obtained in two different crystal forms and the structure of one of them was solved at a resolution of 1.68 angstrom. Our electrophysiological experiments indicated that natrin can block the ion channel currents of the voltage-gated potassium channel Kv1.3. Docking analyses of the interaction between natrin and Kv1.3 revealed a novel interaction pattern different from the two previously reported K+ channel inhibition models termed "functional dyad" and "basic ring". These findings offered new insights into the function of natrin and how the specific interactions between CRISPs and different ion channels can be achieved. (c) 2006 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000242119200021
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被引频次:40[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65499
专题基础医学院_生物物理学系
作者单位1.Chinese Acad Sci, Inst Biophys, Natl Lab Biomacromol, Beijing 100101, Peoples R China
2.Chinese Acad Sci, Inst Biophys, State Key Lab Brain & Cognit Sci, Beijing 100101, Peoples R China
3.Guangxi Med Univ, Snake Venom Res Inst, Nanning 530021, Guangxi, Peoples R China
4.Peking Univ, Hlth Sci Ctr, Dept Biophys, Beijing 100083, Peoples R China
5.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Key Lab Proteom, Shanghai 200031, Peoples R China
6.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
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GB/T 7714
Wang, Feng,Li, He,Liu, Ming-na,et al. Structural and functional analysis of natrin, a venom protein that targets various ion channels[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2006,351(2):443-448.
APA Wang, Feng.,Li, He.,Liu, Ming-na.,Song, Hui.,Han, Hong-mei.,...&Jiang, Tao.(2006).Structural and functional analysis of natrin, a venom protein that targets various ion channels.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,351(2),443-448.
MLA Wang, Feng,et al."Structural and functional analysis of natrin, a venom protein that targets various ion channels".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 351.2(2006):443-448.
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