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学科主题基础医学
Subfornical organ-angiotensin II pressor system takes part in pressor response of emotional circuit
Ku, YH; Li, YH
关键词angiotensin II subfornical organ emotion central amygdaloid nucleus blood pressure
刊名PEPTIDES
2003-07-01
DOI10.1016/S0196-9781(03)00180-3
24期:7页:1063-1067
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
研究领域[WOS]Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
关键词[WOS]ACETYLCHOLINESTERASE-CONTAINING NEURONS ; CORTICOTROPIN-RELEASING FACTOR ; SYMPATHETIC NERVOUS-SYSTEM ; CARDIOVASCULAR-RESPONSES ; SUBSTANCE-P ; PARAVENTRICULAR NUCLEUS ; TOPOGRAPHIC ATLAS ; DEFENSE REACTION ; RAT-BRAIN ; STRESS
英文摘要

It has been proved that there are the subfornical organ (SFO)-nucleus paraventricularis (NPV)-rostral ventrolateral medulla (RVL) angiotension II (AngII) pressor system and the central amygdaloid nucleus (AC)-lateral hypothalamus/perifornical region (LH/PF) emotional pressor system in the brain. Because the LH/PF contains abundant AngII ergic neurons projecting to the SFO, the purpose of the present study was to examine whether the (SFO-NPV-RVL) AngII pressor system takes part in the AC-pressor response via AngII ergic neurons in the LH/PF The results showed that (1) L-glutamate microinjection into the AC or LH/PF induced pressor responses. (2) Both the AC-and LH/PF-pressor responses could be reversed by preinjection of [Sar(1), Thr(8)]-angiotensin II (an antagonist of AngII) into either the SFO, NPV or RVL. Taken together with our previous findings that the projections of the CRF-ergic and SP-ergic neurons in the AC could activate the LH/PF, the above findings prove that: besides several known mechanisms of the brain AngII inducing pressor response, the (SFO-NPV-RVL) AngII pressor system also takes part in the AC-emotional pressor response via AngII ergic projections from the LH/PF to the SFO, which may be the neurophysiological basis of the brain AngII playing an important role in developing hypertension of the SHRs. (C) 2003 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000185668800015
Citation statistics
Cited Times:10[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65502
Collection北京大学基础医学院_生理学与病理生理学系
作者单位Peking Univ, Ctr Hlth Sci, Dept Physiol, Beijing 100083, Peoples R China
Recommended Citation
GB/T 7714
Ku, YH,Li, YH. Subfornical organ-angiotensin II pressor system takes part in pressor response of emotional circuit[J]. PEPTIDES,2003,24(7):1063-1067.
APA Ku, YH,&Li, YH.(2003).Subfornical organ-angiotensin II pressor system takes part in pressor response of emotional circuit.PEPTIDES,24(7),1063-1067.
MLA Ku, YH,et al."Subfornical organ-angiotensin II pressor system takes part in pressor response of emotional circuit".PEPTIDES 24.7(2003):1063-1067.
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