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学科主题: 基础医学
题名:
Subfornical organ-angiotensin II pressor system takes part in pressor response of emotional circuit
作者: Ku, YH; Li, YH
关键词: angiotensin II ; subfornical organ ; emotion ; central amygdaloid nucleus ; blood pressure
刊名: PEPTIDES
发表日期: 2003-07-01
DOI: 10.1016/S0196-9781(03)00180-3
卷: 24, 期:7, 页:1063-1067
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
研究领域[WOS]: Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
关键词[WOS]: ACETYLCHOLINESTERASE-CONTAINING NEURONS ; CORTICOTROPIN-RELEASING FACTOR ; SYMPATHETIC NERVOUS-SYSTEM ; CARDIOVASCULAR-RESPONSES ; SUBSTANCE-P ; PARAVENTRICULAR NUCLEUS ; TOPOGRAPHIC ATLAS ; DEFENSE REACTION ; RAT-BRAIN ; STRESS
英文摘要:

It has been proved that there are the subfornical organ (SFO)-nucleus paraventricularis (NPV)-rostral ventrolateral medulla (RVL) angiotension II (AngII) pressor system and the central amygdaloid nucleus (AC)-lateral hypothalamus/perifornical region (LH/PF) emotional pressor system in the brain. Because the LH/PF contains abundant AngII ergic neurons projecting to the SFO, the purpose of the present study was to examine whether the (SFO-NPV-RVL) AngII pressor system takes part in the AC-pressor response via AngII ergic neurons in the LH/PF The results showed that (1) L-glutamate microinjection into the AC or LH/PF induced pressor responses. (2) Both the AC-and LH/PF-pressor responses could be reversed by preinjection of [Sar(1), Thr(8)]-angiotensin II (an antagonist of AngII) into either the SFO, NPV or RVL. Taken together with our previous findings that the projections of the CRF-ergic and SP-ergic neurons in the AC could activate the LH/PF, the above findings prove that: besides several known mechanisms of the brain AngII inducing pressor response, the (SFO-NPV-RVL) AngII pressor system also takes part in the AC-emotional pressor response via AngII ergic projections from the LH/PF to the SFO, which may be the neurophysiological basis of the brain AngII playing an important role in developing hypertension of the SHRs. (C) 2003 Elsevier Inc. All rights reserved.

语种: 英语
WOS记录号: WOS:000185668800015
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65502
Appears in Collections:基础医学院_生理学与病理生理学系_期刊论文

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作者单位: Peking Univ, Ctr Hlth Sci, Dept Physiol, Beijing 100083, Peoples R China

Recommended Citation:
Ku, YH,Li, YH. Subfornical organ-angiotensin II pressor system takes part in pressor response of emotional circuit[J]. PEPTIDES,2003,24(7):1063-1067.
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