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Neuroprotective effects of echinacoside in the mouse MPTP model of Parkinson′s disease
Geng, Xingchao; Tian, Xuefei; Tu, Pengfei; Pu, Xiaoping
关键词echinacoside Parkinson&prime s disease MPTP MPP(+) apoptosis caspase-3 caspase-8
刊名EUROPEAN JOURNAL OF PHARMACOLOGY
2007-06-14
DOI10.1016/j.ejphar.2007.01.084
564期:1-3页:66-74
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pharmacology & Pharmacy
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]CEREBELLAR GRANULE NEURONS ; PHENYLETHANOID GLYCOSIDES ; APOPTOTIC DEATH ; CELL-DEATH ; 1-METHYL-4-PHENYLPYRIDINIUM ; CASPASE-8 ; RAT ; NEUROTOXICITY ; DEGRADATION ; NECROSIS
英文摘要

In the present study, we investigated the neuroprotective effects of echinacoside, a phenylethanoid glycoside extracted from the medicinal Chinese herb Cistanches salsa, against 1-methyl-4-phenyt-1,2,3,6-tetrahydropyridine (MPTP)-induced dopaminergic toxicity. We confirmed that exposure to MPTP in mice leads to permanent behavioral deficits and depletion of dopamine and its metabolites. When administered prior to MPTP, echinacoside reduced behavioral deficits, increased striatal dopamine and dopamine metabolite levels, reduced cell death, and led to a marked increase in tyrosine hydroxylase expression relative to mice treated with MPTP alone. In addition, pre-treatment with echinacoside significantly reduced caspase-3 and caspase-8 activation in 1-methyl-4-phenytpyridiniLlm (MPP+)-induced apoptosis in cerebellar granule neurons. Taken together, these findings suggest that echinacoside improves the behavioral and neurochemical outcomes in MPTP mice model of Parkinson′s disease and inhibits caspase-3 and caspase-8 activation in cerebellar granule neurons, making the compound an attractive candidate treatment for various neurodegenerative disorders, including Parkinson′s disease. (c) 2007 Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000246998800008
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被引频次:73[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65508
专题北京大学药学院
作者单位1.Peking Univ, Sch Pharmaceut Sci, Dept Mol & Cellular Pharmacol, Beijing 100083, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, Dept Nat Med, Beijing 100083, Peoples R China
3.Peking Univ, Natl Key Res Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China
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GB/T 7714
Geng, Xingchao,Tian, Xuefei,Tu, Pengfei,et al. Neuroprotective effects of echinacoside in the mouse MPTP model of Parkinson′s disease[J]. EUROPEAN JOURNAL OF PHARMACOLOGY,2007,564(1-3):66-74.
APA Geng, Xingchao,Tian, Xuefei,Tu, Pengfei,&Pu, Xiaoping.(2007).Neuroprotective effects of echinacoside in the mouse MPTP model of Parkinson′s disease.EUROPEAN JOURNAL OF PHARMACOLOGY,564(1-3),66-74.
MLA Geng, Xingchao,et al."Neuroprotective effects of echinacoside in the mouse MPTP model of Parkinson′s disease".EUROPEAN JOURNAL OF PHARMACOLOGY 564.1-3(2007):66-74.
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