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学科主题: 药学
题名:
Neuroprotective effects of echinacoside in the mouse MPTP model of Parkinson′s disease
作者: Geng, Xingchao; Tian, Xuefei; Tu, Pengfei; Pu, Xiaoping
关键词: echinacoside ; Parkinson&prime ; s disease ; MPTP ; MPP(+) ; apoptosis ; caspase-3 ; caspase-8
刊名: EUROPEAN JOURNAL OF PHARMACOLOGY
发表日期: 2007-06-14
DOI: 10.1016/j.ejphar.2007.01.084
卷: 564, 期:1-3, 页:66-74
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: CEREBELLAR GRANULE NEURONS ; PHENYLETHANOID GLYCOSIDES ; APOPTOTIC DEATH ; CELL-DEATH ; 1-METHYL-4-PHENYLPYRIDINIUM ; CASPASE-8 ; RAT ; NEUROTOXICITY ; DEGRADATION ; NECROSIS
英文摘要:

In the present study, we investigated the neuroprotective effects of echinacoside, a phenylethanoid glycoside extracted from the medicinal Chinese herb Cistanches salsa, against 1-methyl-4-phenyt-1,2,3,6-tetrahydropyridine (MPTP)-induced dopaminergic toxicity. We confirmed that exposure to MPTP in mice leads to permanent behavioral deficits and depletion of dopamine and its metabolites. When administered prior to MPTP, echinacoside reduced behavioral deficits, increased striatal dopamine and dopamine metabolite levels, reduced cell death, and led to a marked increase in tyrosine hydroxylase expression relative to mice treated with MPTP alone. In addition, pre-treatment with echinacoside significantly reduced caspase-3 and caspase-8 activation in 1-methyl-4-phenytpyridiniLlm (MPP+)-induced apoptosis in cerebellar granule neurons. Taken together, these findings suggest that echinacoside improves the behavioral and neurochemical outcomes in MPTP mice model of Parkinson′s disease and inhibits caspase-3 and caspase-8 activation in cerebellar granule neurons, making the compound an attractive candidate treatment for various neurodegenerative disorders, including Parkinson′s disease. (c) 2007 Elsevier B.V. All rights reserved.

语种: 英语
WOS记录号: WOS:000246998800008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65508
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, Sch Pharmaceut Sci, Dept Mol & Cellular Pharmacol, Beijing 100083, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, Dept Nat Med, Beijing 100083, Peoples R China
3.Peking Univ, Natl Key Res Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China

Recommended Citation:
Geng, Xingchao,Tian, Xuefei,Tu, Pengfei,et al. Neuroprotective effects of echinacoside in the mouse MPTP model of Parkinson′s disease[J]. EUROPEAN JOURNAL OF PHARMACOLOGY,2007,564(1-3):66-74.
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