学科主题临床医学
Regulatory T cells in chronic hepatitis B patients affect the immunopathogenesis of hepatocellular carcinoma by suppressing the anti-tumour immune responses
Zhang, H. H.1; Mei, M. H.2; Fei, R.1; Liu, F.1; Wang, J. H.1; Liao, W. J.2; Qin, L. L.2; Wei, L.1; Chen, H. S.1
关键词chronic hepatitis B hepatocellular carcinoma immune response regulatory T lymphocyte
刊名JOURNAL OF VIRAL HEPATITIS
2010-03-01
DOI10.1111/j.1365-2893.2010.01269.x
suppl.1页:34-43
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Gastroenterology & Hepatology ; Infectious Diseases ; Virology
资助者National Natural Science Foundation of China ; National Key Sci-Tech Special Project of China ; Program for New Century Excellent Talents ; National Basic Research Program ; National 863 plans projects ; National Natural Science Foundation of China ; National Key Sci-Tech Special Project of China ; Program for New Century Excellent Talents ; National Basic Research Program ; National 863 plans projects
研究领域[WOS]Gastroenterology & Hepatology ; Infectious Diseases ; Virology
关键词[WOS]IMMUNOLOGICAL SELF-TOLERANCE ; VIRUS-INFECTION ; NATURAL-HISTORY ; CANCER-PATIENTS ; CUTTING EDGE ; PROLIFERATION ; INCREASE ; ACTIVATION ; INHIBIT ; PEPTIDE
英文摘要

Chronic hepatitis B (CHB) virus hepatitis B virus (HBV) infection is the key cause of hepatocellular carcinoma (HCC) in Asians. Recent studies have shown that levels of CD4+CD25+ regulatory T cells (Tregs) were increased and were linked to an impaired immune response in patients with CHB. Evaluating whether Tregs are involved in the progression of CHB to HCC will provide insight into the immunopathogenesis of HCC. In the present study, we showed that circulating and liver-residing Tregs increased in CHB (n = 15) and HCC (n = 49) patients, particularly in the peripheral blood of HCC patients with HBV infection (n = 29). The increased Tregs in CHB patients suppressed the specific immune response induced by not only HBV antigen, but also by HCC tumour antigen. When peripheral blood mononuclear cells (PBMC) were co-cultured with human hepatoma cell lines that are stably transfected with HBV (HepG2.2.15), CD4+CD25+ Treg populations increased and upregulated the expression of forkhead box P3 transcriptional regulator (FoxP3), cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) and glucocorticoid-induced tumour necrosis factor (TNF) receptor family gene (GITR). In contrast, PBMCs co-cultured with HepG2 cells (the parental cell line of HepG2.2.15) did not. CD4+CD25+ Tregs isolated from PBMCs that were co-cultured with HepG2.2.15 cells also had a greater suppressive ability with respect to the tumour antigen-specific immune response induced by NY-ESO-1 or MAGE-A3 compared with CD4+CD25+ Tregs isolated from PBMCs co-cultured with HepG2 cells. The results offer evidence that the expansion of CD4+CD25+ Tregs and the enhancement of the suppressor function of CD4+CD25+ Tregs induced by HBV infection-related factors could suppress the anti-tumour immune response to HCC tumour antigen and inhibit tumour immuno-surveillance against HCC, which may be involved in the immunopathogenesis from CHB to HCC.

语种英语
所属项目编号30640091 ; 30772499 ; 2008ZX10002-019 ; 985-2-099-113 ; 2005CB522902 ; 2007CB512906 ; 2007AA021103
资助者National Natural Science Foundation of China ; National Key Sci-Tech Special Project of China ; Program for New Century Excellent Talents ; National Basic Research Program ; National 863 plans projects ; National Natural Science Foundation of China ; National Key Sci-Tech Special Project of China ; Program for New Century Excellent Talents ; National Basic Research Program ; National 863 plans projects
WOS记录号WOS:000275184400007
引用统计
被引频次:22[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65516
专题北京大学第二临床医学院_北京大学肝病研究所
作者单位1.Peking Univ, Inst Hepatol, Peoples Hosp, Beijing 100044, Peoples R China
2.Guilin Med Univ, Guilin, Guangxi Prov, Peoples R China
推荐引用方式
GB/T 7714
Zhang, H. H.,Mei, M. H.,Fei, R.,et al. Regulatory T cells in chronic hepatitis B patients affect the immunopathogenesis of hepatocellular carcinoma by suppressing the anti-tumour immune responses[J]. JOURNAL OF VIRAL HEPATITIS,2010,suppl.1:34-43.
APA Zhang, H. H..,Mei, M. H..,Fei, R..,Liu, F..,Wang, J. H..,...&Chen, H. S..(2010).Regulatory T cells in chronic hepatitis B patients affect the immunopathogenesis of hepatocellular carcinoma by suppressing the anti-tumour immune responses.JOURNAL OF VIRAL HEPATITIS,suppl.1,34-43.
MLA Zhang, H. H.,et al."Regulatory T cells in chronic hepatitis B patients affect the immunopathogenesis of hepatocellular carcinoma by suppressing the anti-tumour immune responses".JOURNAL OF VIRAL HEPATITIS suppl.1(2010):34-43.
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