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学科主题: 基础医学
题名:
The suppressive cytokines derived from cancer affect microrheological properties of dendritic cells leading to deteriorated immune response
作者: Zeng, Z; Wang, GT; Xu, XF; Long, JH; Xing, JJ; Zhang, YY; Xiao, J; Duan, XY; Tang, Y; Tang, JM; Sun, DG
关键词: dendritic cells (DCs) ; suppressive cytokines derived from cancer ; immune escape mechanism ; osmotic fragility ; membrane fluidity ; gene transcriptional levels and energy statuses of cells ; immune responses
刊名: PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS
发表日期: 2006-06-01
卷: 33, 期:6, 页:548-555
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]: Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]: TRANSFORM INFRARED-SPECTROSCOPY ; MURINE ERYTHROLEUKEMIA-CELLS ; NECROSIS-FACTOR-ALPHA ; PERIPHERAL-BLOOD ; BIOPHYSICAL PROPERTIES ; ANTIGEN PRESENTATION ; LINE JURKAT ; TGF-BETA ; KAPPA-B ; MATURATION
英文摘要:

The defects and dysfunctions in antigen-presenting dendritic cells have been shown during carcinogenesis leading to human immune system can be markedly suppressed by cancer. To explore the mechanisms by which cancers escape from immune recognition, the influences of tumor microenvironment on differentiation of dendritic cells (DCs), which play an important role in tumor immunology, were studied by biophysical and microrheological methods. It was found that the components derived from tumors caused the increases in osmotic fragility and decreases in membrane fluidity of DCs, moreover, the gene transcriptional levels and energy statuses of cells were also transformed, leading to impaired capabilities of antigen uptaking and deteriorated stimulatory capacities to activate naive T cells. The impaired microrheological properties of DCs may be one of the aspects of immune escape mechanism of tumor.

语种: 中文
WOS记录号: WOS:000238457200007
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65525
Appears in Collections:基础医学院_生物物理学系_期刊论文

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作者单位: 1.Peking Univ, Dept Phys Med, Hlth Sci Ctr, Beijing 100083, Peoples R China
2.Peking Univ, Dept Biophys, Hlth Sci Ctr, Beijing 100083, Peoples R China
3.Peoples Hosp Qiandongnan Dist, Tumor Div, Kaili 556000, Peoples R China
4.Guiyang Med Coll, Dept Med Phys, Guiyang 550004, Peoples R China
5.Peking Univ, Dept Anat & Histol Embryol, Hlth Sci Ctr, Beijing 100083, Peoples R China

Recommended Citation:
Zeng, Z,Wang, GT,Xu, XF,et al. The suppressive cytokines derived from cancer affect microrheological properties of dendritic cells leading to deteriorated immune response[J]. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,2006,33(6):548-555.
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