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Meta-analysis of the efficacy of pancreatoduodenectomy with extended lymphadenectomy in the treatment of pancreatic cancer (Retracted article. See vol. 13, pg. 125, 2015)
Xu, Xinbao1; Zhang, Hui1; Zhou, Ping2; Chen, Lei3
关键词Pancreatic cancer Pancreatoduodenectomy with extended lymphadenectomy Standard pancreatoduodenectomy Meta-analysis
刊名WORLD JOURNAL OF SURGICAL ONCOLOGY
2013-12-10
DOI10.1186/1477-7819-11-311
11
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology ; Surgery
研究领域[WOS]Oncology ; Surgery
关键词[WOS]COMPARING STANDARD PANCREATICODUODENECTOMY ; RETROPERITONEAL LYMPHADENECTOMY ; PERIAMPULLARY ADENOCARCINOMA ; DISTAL GASTRECTOMY ; HEAD ADENOCARCINOMA ; SURGICAL-TREATMENT ; 5-YEAR SURVIVAL ; PART 3 ; CARCINOMA ; RESECTION
英文摘要

Background: The purpose of this meta-analysis is to compare the efficacy of pancreatoduodenectomy (PD) with extended lymphadenectomy (PD/ELND) versus standard PD in the treatment of pancreatic cancer, with the hope of providing evidence for clinical practice.

Methods: The retrieval of relevant literature published before September 2012 was carried out on PubMed, Medline, Embase, and Cochrane Central Register of Controlled Trials (CENTRAL) by computer. Information was extracted according to Cochrane systematic review methods, and analyzed using software Stata 11.0.

Results: Five prospective randomized controlled trials (RCTs) were included in this meta-analysis of 555 cases (278 in the PD/ELND group and 277 in the standard PD group). The PD/ELND group showed a significantly lower 3-year survival rate (relative risk (RR) = 1.46, 95% confidence interval (CI) 1.03 to approximately 2.06, P = 0.034), prolonged operative time (weighted mean difference WMD = -1.03, 95% CI -1.96 to approximately -0.10, P = 0.029) and higher incidence of postoperative complications (RR = 0.56, 95% CI 0.42 to approximately 0.77, P = 0.000) by comparing with standard PD group. Besides, no significant difference was observed in the 1-year survival rate (RR = 0.87, 95% CI 0.60 to approximately 1.25, P = 0.69), 5-year survival rate (RR = 1.04, 95% CI 0.68 to approximately 1.58, P = 0.854), postoperative mortality (RR = 1.14, 95% CI 0.43 to approximately 3.00, P = 0.789), length of stay (WMD = -0.32, 95% CI -2.57 to approximately 1.94, P = 0.784) and the amount of blood transfusions (WMD = -0.14, 95% CI -0.36 to approximately 0.08, P = 0.213).

Conclusions: PD/ELND does not have an advantage over standard PD in the survival rate for patients with pancreatic cancer, but does increase operative time and incidences of postoperative complications.

语种英语
WOS记录号WOS:000329869500001
引用统计
被引频次:12[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65526
专题北京大学第二临床医学院_肝胆外科
作者单位1.AF Gen Hosp Chinese Peoples Liberat Army, Dept Hepatobiliary Surg, Beijing 100142, Peoples R China
2.AF Gen Hosp Chinese Peoples Liberat Army, Dept Radiotherapy, Beijing 100142, Peoples R China
3.Peking Univ, Peoples Hosp, Dept Hepatobiliary Surg, Beijing 100044, Peoples R China
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Xu, Xinbao,Zhang, Hui,Zhou, Ping,et al. Meta-analysis of the efficacy of pancreatoduodenectomy with extended lymphadenectomy in the treatment of pancreatic cancer (Retracted article. See vol. 13, pg. 125, 2015)[J]. WORLD JOURNAL OF SURGICAL ONCOLOGY,2013,11.
APA Xu, Xinbao,Zhang, Hui,Zhou, Ping,&Chen, Lei.(2013).Meta-analysis of the efficacy of pancreatoduodenectomy with extended lymphadenectomy in the treatment of pancreatic cancer (Retracted article. See vol. 13, pg. 125, 2015).WORLD JOURNAL OF SURGICAL ONCOLOGY,11.
MLA Xu, Xinbao,et al."Meta-analysis of the efficacy of pancreatoduodenectomy with extended lymphadenectomy in the treatment of pancreatic cancer (Retracted article. See vol. 13, pg. 125, 2015)".WORLD JOURNAL OF SURGICAL ONCOLOGY 11(2013).
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