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The clinical value of the quantitative detection of four cancer-testis antigen genes in multiple myeloma
Zhang, Yao; Bao, Li; Lu, Jin; Liu, Kai-Yan; Li, Jin-Lan; Qin, Ya-Zhen; Chen, Huan; Li, Ling-Di; Kong, Yuan; Shi, Hong-Xia; Lai, Yue-Yun; Liu, Yan-Rong; Jiang, Bin; Chen, Shan-Shan; Huang, Xiao-Jun1; Ruan, Guo-Rui
关键词Cancer-testis antigen gene Multiple myeloma Real-time quantitative polymerase chain reaction
刊名MOLECULAR CANCER
2014-02-05
DOI10.1186/1476-4598-13-25
13
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Oncology
研究领域[WOS]Biochemistry & Molecular Biology ; Oncology
关键词[WOS]RESIDUAL DISEASE ; EXPRESSION ; CT7 ; MALIGNANCIES ; MAGE-C1/CT7 ; PROGNOSIS ; MARKERS ; PCR
英文摘要

Background: Cancer-testis (CT) antigen genes might promote the progression of multiple myeloma (MM). CT antigens may act as diagnostic and prognostic markers in MM, but their expression levels and clinical implications in this disease are not fully understood. This study measured the expression levels of four CT antigen genes in Chinese patients with MM and explored their clinical implications.

Methods: Real-time quantitative polymerase chain reaction (qPCR) was used to quantify the expression of MAGE-C1/CT7, MAGE-A3, MAGE-C2/CT10 and SSX-2 mRNA in 256 bone marrow samples from 144 MM patients.

Results: In the newly diagnosed patients, the positive expression rates were 88.5% for MAGE-C1/CT7, 82.1% for MAGE-C2/CT10, 76.9% for MAGE-A3 and 25.6% for SSX-2. The expression levels and the number of co-expressed CT antigens correlated significantly with several clinical indicators, including the percentage of plasma cells infiltrating the bone marrow, abnormal chromosome karyotypes and the clinical course.

Conclusion: MAGE-C1/CT7, MAGE-A3, MAGE-C2/CT10 and SSX-2 expression levels provide potentially effective clinical indicators for the auxiliary diagnosis and monitoring of treatment efficacy in MM.

语种英语
WOS记录号WOS:000331565200002
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65527
专题北京大学第二临床医学院
北京大学第二临床医学院_血液科
作者单位1.Peking Univ, Peoples Hosp, Beijing 100044, Peoples R China
2.Peking Univ, Beijing Key Lab Hematopoiet Stem Cell Transplanta, Inst Hematol, Beijing 100044, Peoples R China
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GB/T 7714
Zhang, Yao,Bao, Li,Lu, Jin,et al. The clinical value of the quantitative detection of four cancer-testis antigen genes in multiple myeloma[J]. MOLECULAR CANCER,2014,13.
APA Zhang, Yao.,Bao, Li.,Lu, Jin.,Liu, Kai-Yan.,Li, Jin-Lan.,...&Ruan, Guo-Rui.(2014).The clinical value of the quantitative detection of four cancer-testis antigen genes in multiple myeloma.MOLECULAR CANCER,13.
MLA Zhang, Yao,et al."The clinical value of the quantitative detection of four cancer-testis antigen genes in multiple myeloma".MOLECULAR CANCER 13(2014).
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