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Sex differences in use of psychotropic drugs and drug-induced side effects in schizophrenia patients: Findings of the Research on Asia Psychotropic Prescription (REAP) studies
Xiang, Yu-Tao2,3; Wang, Chuan-Yue3; Si, Tian-Mei1; Lee, Edwin Ho Ming4; He, Yan-Ling5; Ungvari, Gabor S.6; Chiu, Helen F. K.4; Yang, Shu-Yu7; Chong, Mian-Yoon8; Shinfuku, Naotaka9; Tan, Chay Hoon10; Kua, Ee Heok10; Fujii, Senta11; Sim, Kang12; Yong, K. H.12; Trivedi, Jitendra Kumar13; Chung, Eun Kee14; Udomratn, Pichet15; Chee, Kok-Yoon16; Sartorius, Norman17
关键词prescription schizophrenia sex differences
刊名AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY
2011-03-01
45期:3页:193-198
收录类别SCI ; SSCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Psychiatry
研究领域[WOS]Psychiatry
关键词[WOS]BODY-MASS INDEX ; QUALITY-OF-LIFE ; GENDER-DIFFERENCES ; ANTIPSYCHOTIC-DRUGS ; EAST-ASIA ; WEIGHT-GAIN ; ATYPICAL ANTIPSYCHOTICS ; TARDIVE-DYSKINESIA ; MOOD STABILIZERS ; OUTPATIENTS
英文摘要

Objective: The aim of this study was to investigate the sex differences in prescribing patterns of psychotropic drugs and drug-induced side effects in schizophrenia patients in Asia using the data of the Research on Asian Psychotropic Prescription Pattern ( REAP) surveys.

Method: The prescription patterns of 6,441 schizophrenia inpatients in six Asian countries and regions were investigated during the 2001--2009 period. The patients′ socio-demographic and clinical characteristics and their prescriptions for psychotropic drugs were recorded using a standardized protocol and data collection procedure.

Results: Univariate analyses found the following factors to be significantly associated with the male sex: a younger age, higher doses of antipsychotics, less prominent delusions and hallucinations, more prominent negative symptoms, less likelihood of a prescription for second-generation antipsychotics (SGAs), greater use of antipsychotic polypharmacy, mood stabilizers and depot antipsychotics, more frequent tardive dyskinesia (TD), and less weight gain. In multivariate analyses, fewer prescriptions for SGAs, greater use of mood stabilizers, anticholinergics, antipsychotic polypharmacy and depot antipsychotics, extrapyramidal side effects (EPS) and TD, and less weight gain were independently associated with the male sex.

Conclusions: Sex is one of the independent contributors to psychotropic prescription and side effects in Asian schizophrenia patients. Psychopharmacological treatment guidelines for schizophrenia should consider the sexes separately.

语种英语
WOS记录号WOS:000287742800003
项目编号30800367 ; 30770776 ; 2008B59 ; 2041454 ; CRC 249/2008 ; DOH92-NH-1025 ; CMRPG83043 ; 97001-62-010
资助机构National Science Foundation of China ; Beijing Municipal Science and Technology Commission ; Chinese University of Hong Kong ; Institute of Mental Health in Singapore ; Taiwan Bureau of National Health Insurance, Chang Gung Memorial Hospital, Taipei City Government in Taiwan
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65529
专题北京大学精神卫生研究所
作者单位1.Seinan Gakuin Univ Fukuoka, Sch Human Sci, Fukuoka, Japan
2.Natl Univ Singapore, Singapore 117548, Singapore
3.HITS, Kobe, Hyogo, Japan
4.Inst Mental Hlth, Buangkok View, Singapore
5.CSM Med Univ, Dept Psychiat, Lucknow 226003, Uttar Pradesh, India
6.Natl Seoul Hosp, Seoul, South Korea
7.Prince Songkla Univ, Hat Yai, Thailand
8.Univ Geneva, Geneva, Switzerland
9.Chinese Univ Hong Kong, Tai Po Hosp, Dept Psychiat, Tai Po, Hong Kong, Peoples R China
10.Capital Med Univ, Beijing Anding Hosp, Beijing, Peoples R China
11.Chinese Univ Hong Kong, Dept Psychiat, Hong Kong, Hong Kong, Peoples R China
12.Univ Western Australia, Sch Psychiat & Clin Neurosci, Perth, WA 6009, Australia
13.Kuala Lumpur Hosp, Tunku Abdul Rahman Inst Neurosci, Dept Psychiat & Mental Hlth, Kuala Lumpur, Malaysia
14.Peking Univ, Inst Mental Hlth, Beijing 100871, Peoples R China
15.Shanghai Mental Hlth Ctr, Shanghai, Peoples R China
16.Taipei City Hosp, Taipei, Taiwan
17.Kaohsiung Chang Gung Mem Hosp, Kaohsiung, Taiwan
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GB/T 7714
Xiang, Yu-Tao,Wang, Chuan-Yue,Si, Tian-Mei,et al. Sex differences in use of psychotropic drugs and drug-induced side effects in schizophrenia patients: Findings of the Research on Asia Psychotropic Prescription (REAP) studies[J]. AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY,2011,45(3):193-198.
APA Xiang, Yu-Tao.,Wang, Chuan-Yue.,Si, Tian-Mei.,Lee, Edwin Ho Ming.,He, Yan-Ling.,...&Sartorius, Norman.(2011).Sex differences in use of psychotropic drugs and drug-induced side effects in schizophrenia patients: Findings of the Research on Asia Psychotropic Prescription (REAP) studies.AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY,45(3),193-198.
MLA Xiang, Yu-Tao,et al."Sex differences in use of psychotropic drugs and drug-induced side effects in schizophrenia patients: Findings of the Research on Asia Psychotropic Prescription (REAP) studies".AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY 45.3(2011):193-198.
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