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学科主题: 精神卫生
题名:
Sex differences in use of psychotropic drugs and drug-induced side effects in schizophrenia patients: Findings of the Research on Asia Psychotropic Prescription (REAP) studies
作者: Xiang, Yu-Tao2,3; Wang, Chuan-Yue3; Si, Tian-Mei1; Lee, Edwin Ho Ming4; He, Yan-Ling5; Ungvari, Gabor S.6; Chiu, Helen F. K.4; Yang, Shu-Yu7; Chong, Mian-Yoon8; Shinfuku, Naotaka9; Tan, Chay Hoon10; Kua, Ee Heok10; Fujii, Senta11; Sim, Kang12; Yong, K. H.12; Trivedi, Jitendra Kumar13; Chung, Eun Kee14; Udomratn, Pichet15; Chee, Kok-Yoon16; Sartorius, Norman17
关键词: prescription ; schizophrenia ; sex differences
刊名: AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY
发表日期: 2011-03-01
卷: 45, 期:3, 页:193-198
收录类别: SCI ; SSCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Psychiatry
研究领域[WOS]: Psychiatry
关键词[WOS]: BODY-MASS INDEX ; QUALITY-OF-LIFE ; GENDER-DIFFERENCES ; ANTIPSYCHOTIC-DRUGS ; EAST-ASIA ; WEIGHT-GAIN ; ATYPICAL ANTIPSYCHOTICS ; TARDIVE-DYSKINESIA ; MOOD STABILIZERS ; OUTPATIENTS
英文摘要:

Objective: The aim of this study was to investigate the sex differences in prescribing patterns of psychotropic drugs and drug-induced side effects in schizophrenia patients in Asia using the data of the Research on Asian Psychotropic Prescription Pattern ( REAP) surveys.

Method: The prescription patterns of 6,441 schizophrenia inpatients in six Asian countries and regions were investigated during the 2001--2009 period. The patients′ socio-demographic and clinical characteristics and their prescriptions for psychotropic drugs were recorded using a standardized protocol and data collection procedure.

Results: Univariate analyses found the following factors to be significantly associated with the male sex: a younger age, higher doses of antipsychotics, less prominent delusions and hallucinations, more prominent negative symptoms, less likelihood of a prescription for second-generation antipsychotics (SGAs), greater use of antipsychotic polypharmacy, mood stabilizers and depot antipsychotics, more frequent tardive dyskinesia (TD), and less weight gain. In multivariate analyses, fewer prescriptions for SGAs, greater use of mood stabilizers, anticholinergics, antipsychotic polypharmacy and depot antipsychotics, extrapyramidal side effects (EPS) and TD, and less weight gain were independently associated with the male sex.

Conclusions: Sex is one of the independent contributors to psychotropic prescription and side effects in Asian schizophrenia patients. Psychopharmacological treatment guidelines for schizophrenia should consider the sexes separately.

语种: 英语
所属项目编号: 30800367 ; 30770776 ; 2008B59 ; 2041454 ; CRC 249/2008 ; DOH92-NH-1025 ; CMRPG83043 ; 97001-62-010
项目资助者: National Science Foundation of China ; Beijing Municipal Science and Technology Commission ; Chinese University of Hong Kong ; Institute of Mental Health in Singapore ; Taiwan Bureau of National Health Insurance, Chang Gung Memorial Hospital, Taipei City Government in Taiwan
WOS记录号: WOS:000287742800003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65529
Appears in Collections:北京大学精神卫生研究所_期刊论文

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作者单位: 1.Seinan Gakuin Univ Fukuoka, Sch Human Sci, Fukuoka, Japan
2.Natl Univ Singapore, Singapore 117548, Singapore
3.HITS, Kobe, Hyogo, Japan
4.Inst Mental Hlth, Buangkok View, Singapore
5.CSM Med Univ, Dept Psychiat, Lucknow 226003, Uttar Pradesh, India
6.Natl Seoul Hosp, Seoul, South Korea
7.Prince Songkla Univ, Hat Yai, Thailand
8.Univ Geneva, Geneva, Switzerland
9.Chinese Univ Hong Kong, Tai Po Hosp, Dept Psychiat, Tai Po, Hong Kong, Peoples R China
10.Capital Med Univ, Beijing Anding Hosp, Beijing, Peoples R China
11.Chinese Univ Hong Kong, Dept Psychiat, Hong Kong, Hong Kong, Peoples R China
12.Univ Western Australia, Sch Psychiat & Clin Neurosci, Perth, WA 6009, Australia
13.Kuala Lumpur Hosp, Tunku Abdul Rahman Inst Neurosci, Dept Psychiat & Mental Hlth, Kuala Lumpur, Malaysia
14.Peking Univ, Inst Mental Hlth, Beijing 100871, Peoples R China
15.Shanghai Mental Hlth Ctr, Shanghai, Peoples R China
16.Taipei City Hosp, Taipei, Taiwan
17.Kaohsiung Chang Gung Mem Hosp, Kaohsiung, Taiwan

Recommended Citation:
Xiang, Yu-Tao,Wang, Chuan-Yue,Si, Tian-Mei,et al. Sex differences in use of psychotropic drugs and drug-induced side effects in schizophrenia patients: Findings of the Research on Asia Psychotropic Prescription (REAP) studies[J]. AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY,2011,45(3):193-198.
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