IR@PKUHSC  > 北京大学第一临床医学院
学科主题临床医学
LMP2/LMP7 gene variant: A risk factor for intestinal Mycobacterium tuberculosis infection in the Chinese population
Lv, Yuan2,3; Yan, Bo4; Yang, Hongli1; Liu, Jian2,3; Zhong, Wei2,3; Li, Kun1; Chen, Ziping1; Xu, Changqing1
关键词low molecular mass protein-2 gene low molecular mass protein-7 gene Mycobacterium tuberculosis infection susceptibility
刊名JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
2011-07-01
DOI10.1111/j.1440-1746.2011.06693.x
26期:7页:1145-1150
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Gastroenterology & Hepatology
研究领域[WOS]Gastroenterology & Hepatology
关键词[WOS]CARCINOMA ; POLYMORPHISMS ; HUMANS ; CD4(+) ; CELLS
英文摘要

Background and Aims: Low molecular mass protein-2 (LMP2) and low molecular mass protein-7 (LMP7) genes play a critical role in foreign antigen processing on the major histocompatibility complex-1 CD8(+) cytotoxic T-lymphocyte pathway. This study was designed to investigate whether the sequence variants in the LMP2/LMP7 coding region were associated with intestinal Mycobacterium tuberculosis (M. tuberculosis) infection or with the co-infection of pulmonary tuberculosis.

Methods: A total of 168 patients with intestinal tuberculosis and 235 normal controls were recruited for this study. Two polymorphisms of LMP2 (Arg60-His) and LMP7 (Gln145-Lys) were identified by polymerase chain reaction restriction fragment length polymorphism method. The associations of the LMP2/LMP7 genotype and haplotype with intestinal M. tuberculosis infection were assessed by using logistic regression analysis.

Results: The results revealed that LMP7 position codon 145 Lys/Lys and Gln/Lys alleles in the coding region were associated with the infection of intestinal M. tuberculosis (P=0.003, odds ratio [OR] = 3.86 and P < 0.001, OR = 2.28, respectively). Meanwhile, the Arg-Lys and Cys-Lys haplotypes exhibited significant relation to the intestinal M. tuberculosis infection (P=0.006, OR = 1.87; P=0.021, OR = 1.83, respectively). No significant associations were observed for any of the single-nucleotide polymorphism genotypes or haplotypes with the co-infection of pulmonary tuberculosis (P>0.05).

Conclusions: The results indicated that the genetic variant within the LMP2/LMP7 gene would increase the risk of intestinal M. tuberculosis infection.

语种英语
WOS记录号WOS:000292478200009
资助机构"985" Project Foundation of Ministry of Education, China
引用统计
被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65530
专题北京大学第一临床医学院
北京大学口腔医学院_口腔预防保健科
作者单位1.Shandong Univ, Dept Gastroenterol, Shandong Qianfoshan Hosp, Coll Med, Jinan 250014, Shandong, Peoples R China
2.Peking Univ, Dept Antiinfect, Hosp 1, Beijing 100871, Peoples R China
3.Peking Univ, Inst Clin Pharmacol, Hosp 1, Beijing 100871, Peoples R China
4.Univ Texas Hlth Sci Ctr San Antonio, Dept Microbiol & Immunol, San Antonio, TX 78229 USA
推荐引用方式
GB/T 7714
Lv, Yuan,Yan, Bo,Yang, Hongli,et al. LMP2/LMP7 gene variant: A risk factor for intestinal Mycobacterium tuberculosis infection in the Chinese population[J]. JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY,2011,26(7):1145-1150.
APA Lv, Yuan.,Yan, Bo.,Yang, Hongli.,Liu, Jian.,Zhong, Wei.,...&Xu, Changqing.(2011).LMP2/LMP7 gene variant: A risk factor for intestinal Mycobacterium tuberculosis infection in the Chinese population.JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY,26(7),1145-1150.
MLA Lv, Yuan,et al."LMP2/LMP7 gene variant: A risk factor for intestinal Mycobacterium tuberculosis infection in the Chinese population".JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY 26.7(2011):1145-1150.
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