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学科主题: 临床医学
题名:
LMP2/LMP7 gene variant: A risk factor for intestinal Mycobacterium tuberculosis infection in the Chinese population
作者: Lv, Yuan2,3; Yan, Bo4; Yang, Hongli1; Liu, Jian2,3; Zhong, Wei2,3; Li, Kun1; Chen, Ziping1; Xu, Changqing1
关键词: low molecular mass protein-2 gene ; low molecular mass protein-7 gene ; Mycobacterium tuberculosis infection ; susceptibility
刊名: JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
发表日期: 2011-07-01
DOI: 10.1111/j.1440-1746.2011.06693.x
卷: 26, 期:7, 页:1145-1150
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Gastroenterology & Hepatology
研究领域[WOS]: Gastroenterology & Hepatology
关键词[WOS]: CARCINOMA ; POLYMORPHISMS ; HUMANS ; CD4(+) ; CELLS
英文摘要:

Background and Aims: Low molecular mass protein-2 (LMP2) and low molecular mass protein-7 (LMP7) genes play a critical role in foreign antigen processing on the major histocompatibility complex-1 CD8(+) cytotoxic T-lymphocyte pathway. This study was designed to investigate whether the sequence variants in the LMP2/LMP7 coding region were associated with intestinal Mycobacterium tuberculosis (M. tuberculosis) infection or with the co-infection of pulmonary tuberculosis.

Methods: A total of 168 patients with intestinal tuberculosis and 235 normal controls were recruited for this study. Two polymorphisms of LMP2 (Arg60-His) and LMP7 (Gln145-Lys) were identified by polymerase chain reaction restriction fragment length polymorphism method. The associations of the LMP2/LMP7 genotype and haplotype with intestinal M. tuberculosis infection were assessed by using logistic regression analysis.

Results: The results revealed that LMP7 position codon 145 Lys/Lys and Gln/Lys alleles in the coding region were associated with the infection of intestinal M. tuberculosis (P=0.003, odds ratio [OR] = 3.86 and P < 0.001, OR = 2.28, respectively). Meanwhile, the Arg-Lys and Cys-Lys haplotypes exhibited significant relation to the intestinal M. tuberculosis infection (P=0.006, OR = 1.87; P=0.021, OR = 1.83, respectively). No significant associations were observed for any of the single-nucleotide polymorphism genotypes or haplotypes with the co-infection of pulmonary tuberculosis (P>0.05).

Conclusions: The results indicated that the genetic variant within the LMP2/LMP7 gene would increase the risk of intestinal M. tuberculosis infection.

语种: 英语
项目资助者: "985" Project Foundation of Ministry of Education, China
WOS记录号: WOS:000292478200009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65530
Appears in Collections:北京大学第一临床医学院_期刊论文

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作者单位: 1.Shandong Univ, Dept Gastroenterol, Shandong Qianfoshan Hosp, Coll Med, Jinan 250014, Shandong, Peoples R China
2.Peking Univ, Dept Antiinfect, Hosp 1, Beijing 100871, Peoples R China
3.Peking Univ, Inst Clin Pharmacol, Hosp 1, Beijing 100871, Peoples R China
4.Univ Texas Hlth Sci Ctr San Antonio, Dept Microbiol & Immunol, San Antonio, TX 78229 USA

Recommended Citation:
Lv, Yuan,Yan, Bo,Yang, Hongli,et al. LMP2/LMP7 gene variant: A risk factor for intestinal Mycobacterium tuberculosis infection in the Chinese population[J]. JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY,2011,26(7):1145-1150.
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