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Six-month changes in cytokine levels after intravitreal bevacizumab injection for diabetic macular oedema and macular oedema due to central retinal vein occlusion
Wen, Jing1,2,3; Jiang, Yanrong1,2,3; Zheng, Xiaoxue1,2,3; Zhou, Ying1,2,3
刊名BRITISH JOURNAL OF OPHTHALMOLOGY
2015-10-01
DOI10.1136/bjophthalmol-2014-306341
99期:10页:1334-1340
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Ophthalmology
研究领域[WOS]Ophthalmology
关键词[WOS]AQUEOUS CONCENTRATIONS ; RETINOPATHY ; INTERLEUKIN-6 ; EXPRESSION ; THERAPY
英文摘要

Background/aims This study evaluated the impact of intravitreal injection of bevacizumab (IVB) on the microenvironment of the eyes of diabetic macular oedema (DMO) and macular oedema due to central retinal vein occlusion (CRVO-MO) patients.

Methods This study comprised 136 patients, including 51 patients in the DMO group, 70 in the CRVO-MO group and 15 in the control group, who were followed for 6 months after IVB. Angiogenic cytokines, inflammatory cytokines and growth factors concentrations in the aqueous humour were measured before and after IVB using suspension array technology. We compared the levels of cytokines among DMO patients, CRVO-MO patients and control patients. We compared the levels of cytokines among groups according to the interval between the first and second injections of bevacizumab and according to the number of injections received during the 6-month follow-up period.

Results Significantly higher concentrations of vascular endothelial growth factor (VEGF), transforming growth factor beta (TGF-beta), hepatocyte growth factor (HGF), interleukin 6 (IL-6), serum amyloid A (SAA) and monocyte chemoattractant protein-1 (MCP-1) were found in the aqueous humour of DMO and CRVO-MO patients compared with cataract patients. One month after IVB, the intraocular concentrations of VEGF were significantly decreased in the eyes of DMO (p=0.045) and CRVO-MO (p=0.002) patients compared with baseline. No other cytokine was significantly altered by bevacizumab therapy.

Conclusions Angiogenic, inflammatory and growth factors are involved in the development of DMO and CRVO-MO. In addition to VEGF, IVB did not cause significant differences in other inflammatory cytokines and growth factors in DMO and CRVO-MO patients.

语种英语
WOS记录号WOS:000362821400006
项目编号81271027 ; 2127000043 ; 20110001110042 ; RDC2012-21
资助机构National Natural Science Foundation of China ; EFSD/CDS/Lilly grant ; Research Fund for the Doctoral Program of Higher Education of China ; Peking University People&prime ; s Hospital Research and Development Funds
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65531
专题北京大学第二临床医学院_眼科
作者单位1.Peking Univ, Peoples Hosp, Dept Ophthalmol, Beijing 100044, Peoples R China
2.Peking Univ, Minist Educ, Key Lab Vis Loss & Restorat, Beijing 100044, Peoples R China
3.Beijing Key Lab Diag & Therapy Retinal & Choroid, Beijing, Peoples R China
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GB/T 7714
Wen, Jing,Jiang, Yanrong,Zheng, Xiaoxue,et al. Six-month changes in cytokine levels after intravitreal bevacizumab injection for diabetic macular oedema and macular oedema due to central retinal vein occlusion[J]. BRITISH JOURNAL OF OPHTHALMOLOGY,2015,99(10):1334-1340.
APA Wen, Jing,Jiang, Yanrong,Zheng, Xiaoxue,&Zhou, Ying.(2015).Six-month changes in cytokine levels after intravitreal bevacizumab injection for diabetic macular oedema and macular oedema due to central retinal vein occlusion.BRITISH JOURNAL OF OPHTHALMOLOGY,99(10),1334-1340.
MLA Wen, Jing,et al."Six-month changes in cytokine levels after intravitreal bevacizumab injection for diabetic macular oedema and macular oedema due to central retinal vein occlusion".BRITISH JOURNAL OF OPHTHALMOLOGY 99.10(2015):1334-1340.
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