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学科主题: 公共卫生
题名:
Oral Administration of Skin Gelatin Isolated from Chum Salmon (Oncorhynchus keta) Enhances Wound Healing in Diabetic Rats
作者: Zhang, Zhaofeng; Zhao, Ming; Wang, Junbo; Ding, Ye; Dai, Xiaoqian; Li, Yong
关键词: skin gelatin ; wound healing ; diabetic rats ; angiogenesis
刊名: MARINE DRUGS
发表日期: 2011-05-01
DOI: 10.3390/md9050696
卷: 9, 期:5, 页:696-711
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Medicinal
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: GROWTH-FACTOR ; BONE GELATIN ; NITRIC-OXIDE ; ANGIOGENESIS ; EXPRESSION ; VEGF ; MICE ; HYDROLYSATE ; EXTRACTION ; ADHESION
英文摘要:

Care for diabetic wounds remains a significant clinical problem. The present study was aimed at investigating the effect of skin gelatin from Chum Salmon on defective wound repair in the skin of diabetic rats. Full-thickness excisional skin wounds were made in 48 rats, of which 32 were diabetes. The diabetic rats were orally treated daily for 14 days with skin gelatin from Chum Salmon (2 g/kg) or its vehicle. Sixteen non-diabetic control rats received the same amount of water as vehicle-treated non-diabetic rats. Rats were killed to assess the rate of wound closure, microvessel density (MVD), vascular endothelial growth factor (VEGF), hydroxyproline (HP) contents in wound tissues and nitrate in plasma and wound tissue at 7 and 14 days after wounding. Skin gelatin-treated diabetic rats showed a better wound closure, increased MVD, VEGF, hyproxyproline and NO contents and a reduced extent of inflammatory response. All parameters were significant (P < 0.05) in comparison to vehicle-treated diabetic group. In light of our finding that skin gelatin of Chum Salmon promotes skin wound repair in diabetic rats, we propose that oral administration of Chum Salmon skin gelatin might be a beneficial method for treating wound disorders associated with diabetes.

语种: 英语
所属项目编号: 2006BAD27B01
项目资助者: Ministry of Science and Technology of the People&prime ; s Republic of China
WOS记录号: WOS:000292632500002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65534
Appears in Collections:北京大学公共卫生学院_期刊论文

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作者单位: Peking Univ, Sch Publ Hlth, Dept Food Hyg & Nutr, Beijing 100191, Peoples R China

Recommended Citation:
Zhang, Zhaofeng,Zhao, Ming,Wang, Junbo,et al. Oral Administration of Skin Gelatin Isolated from Chum Salmon (Oncorhynchus keta) Enhances Wound Healing in Diabetic Rats[J]. MARINE DRUGS,2011,9(5):696-711.
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