IR@PKUHSC  > 北京大学公共卫生学院
学科主题公共卫生
Oral Administration of Skin Gelatin Isolated from Chum Salmon (Oncorhynchus keta) Enhances Wound Healing in Diabetic Rats
Zhang, Zhaofeng; Zhao, Ming; Wang, Junbo; Ding, Ye; Dai, Xiaoqian; Li, Yong
关键词skin gelatin wound healing diabetic rats angiogenesis
刊名MARINE DRUGS
2011-05-01
DOI10.3390/md9050696
9期:5页:696-711
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Medicinal
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]GROWTH-FACTOR ; BONE GELATIN ; NITRIC-OXIDE ; ANGIOGENESIS ; EXPRESSION ; VEGF ; MICE ; HYDROLYSATE ; EXTRACTION ; ADHESION
英文摘要

Care for diabetic wounds remains a significant clinical problem. The present study was aimed at investigating the effect of skin gelatin from Chum Salmon on defective wound repair in the skin of diabetic rats. Full-thickness excisional skin wounds were made in 48 rats, of which 32 were diabetes. The diabetic rats were orally treated daily for 14 days with skin gelatin from Chum Salmon (2 g/kg) or its vehicle. Sixteen non-diabetic control rats received the same amount of water as vehicle-treated non-diabetic rats. Rats were killed to assess the rate of wound closure, microvessel density (MVD), vascular endothelial growth factor (VEGF), hydroxyproline (HP) contents in wound tissues and nitrate in plasma and wound tissue at 7 and 14 days after wounding. Skin gelatin-treated diabetic rats showed a better wound closure, increased MVD, VEGF, hyproxyproline and NO contents and a reduced extent of inflammatory response. All parameters were significant (P < 0.05) in comparison to vehicle-treated diabetic group. In light of our finding that skin gelatin of Chum Salmon promotes skin wound repair in diabetic rats, we propose that oral administration of Chum Salmon skin gelatin might be a beneficial method for treating wound disorders associated with diabetes.

语种英语
WOS记录号WOS:000292632500002
引用统计
被引频次:15[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65534
专题北京大学公共卫生学院
北京大学药学院_化学生物学系
北京大学公共卫生学院_营养与食品卫生学系
北京大学公共卫生学院_公共卫生学院
作者单位Peking Univ, Sch Publ Hlth, Dept Food Hyg & Nutr, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Zhang, Zhaofeng,Zhao, Ming,Wang, Junbo,et al. Oral Administration of Skin Gelatin Isolated from Chum Salmon (Oncorhynchus keta) Enhances Wound Healing in Diabetic Rats[J]. MARINE DRUGS,2011,9(5):696-711.
APA Zhang, Zhaofeng,Zhao, Ming,Wang, Junbo,Ding, Ye,Dai, Xiaoqian,&Li, Yong.(2011).Oral Administration of Skin Gelatin Isolated from Chum Salmon (Oncorhynchus keta) Enhances Wound Healing in Diabetic Rats.MARINE DRUGS,9(5),696-711.
MLA Zhang, Zhaofeng,et al."Oral Administration of Skin Gelatin Isolated from Chum Salmon (Oncorhynchus keta) Enhances Wound Healing in Diabetic Rats".MARINE DRUGS 9.5(2011):696-711.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Zhang, Zhaofeng]的文章
[Zhao, Ming]的文章
[Wang, Junbo]的文章
百度学术
百度学术中相似的文章
[Zhang, Zhaofeng]的文章
[Zhao, Ming]的文章
[Wang, Junbo]的文章
必应学术
必应学术中相似的文章
[Zhang, Zhaofeng]的文章
[Zhao, Ming]的文章
[Wang, Junbo]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。