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学科主题: 药物依赖
题名:
Chronic unpredictable stress induces a reversible change of PER2 rhythm in the suprachiasmatic nucleus
作者: Jiang, Wen-Gao; Li, Su-Xia; Zhou, Shuang-Jiang; Sun, Yan; Shi, Jie; Lu, Lin
关键词: Chronic unpredictable stress ; Depression ; Period 2 ; Suprachiasmatic nucleus
刊名: BRAIN RESEARCH
发表日期: 2011-06-05
DOI: 10.1016/j.brainres.2011.05.001
卷: 1399, 页:25-32
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: CHRONIC MILD STRESS ; CIRCADIAN-CLOCK ; LOCOMOTOR-ACTIVITY ; GENE-EXPRESSION ; PHASE-SHIFTS ; DEPRESSION ; RATS ; HYPOTHALAMUS ; MPER2 ; MICE
英文摘要:

Many clinical studies have shown that circadian rhythm abnormalities are strongly associated with major depression. The master clock of the circadian system in mammals is located in the suprachiasmatic nucleus (SCN) within the anterior hypothalamus, where Per1 and Per2 are essential core components of circadian rhythm oscillation. Chronic unpredictable stress (CUS) is a reliable animal model of depression with good face, predictive, and constructive validity. In the present study, we investigated the effects of CUS on the circadian expression of PER1 and PER2 in the SCN. We found that CUS led to depressive-like behavior and reduced the amplitude of PER2 oscillation in the SCN, which were blocked by 3 weeks of desipramine (DMI) treatment. 2 weeks after termination of CUS, the decreased peak of PER2 expression returned to control levels, whereas depressive-like behavior remained unchanged. Our findings suggest that the dampened amplitude of PER2 expression in the SCN may participate in the development of depressive-like behavior induced by CUS but is unlikely involved in the long-lasting effects of CUS on depressive-like behavior. (C) 2011 Elsevier B.V. All rights reserved.

语种: 英语
所属项目编号: 30800362
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000292571900003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65535
Appears in Collections:中国药物依赖性研究所_期刊论文

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作者单位: Peking Univ, Natl Inst Drug Dependence, Beijing 100191, Peoples R China

Recommended Citation:
Jiang, Wen-Gao,Li, Su-Xia,Zhou, Shuang-Jiang,et al. Chronic unpredictable stress induces a reversible change of PER2 rhythm in the suprachiasmatic nucleus[J]. BRAIN RESEARCH,2011,1399:25-32.
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