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Chronic unpredictable stress induces a reversible change of PER2 rhythm in the suprachiasmatic nucleus
Jiang, Wen-Gao; Li, Su-Xia; Zhou, Shuang-Jiang; Sun, Yan; Shi, Jie; Lu, Lin
关键词Chronic unpredictable stress Depression Period 2 Suprachiasmatic nucleus
刊名BRAIN RESEARCH
2011-06-05
DOI10.1016/j.brainres.2011.05.001
1399页:25-32
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]CHRONIC MILD STRESS ; CIRCADIAN-CLOCK ; LOCOMOTOR-ACTIVITY ; GENE-EXPRESSION ; PHASE-SHIFTS ; DEPRESSION ; RATS ; HYPOTHALAMUS ; MPER2 ; MICE
英文摘要

Many clinical studies have shown that circadian rhythm abnormalities are strongly associated with major depression. The master clock of the circadian system in mammals is located in the suprachiasmatic nucleus (SCN) within the anterior hypothalamus, where Per1 and Per2 are essential core components of circadian rhythm oscillation. Chronic unpredictable stress (CUS) is a reliable animal model of depression with good face, predictive, and constructive validity. In the present study, we investigated the effects of CUS on the circadian expression of PER1 and PER2 in the SCN. We found that CUS led to depressive-like behavior and reduced the amplitude of PER2 oscillation in the SCN, which were blocked by 3 weeks of desipramine (DMI) treatment. 2 weeks after termination of CUS, the decreased peak of PER2 expression returned to control levels, whereas depressive-like behavior remained unchanged. Our findings suggest that the dampened amplitude of PER2 expression in the SCN may participate in the development of depressive-like behavior induced by CUS but is unlikely involved in the long-lasting effects of CUS on depressive-like behavior. (C) 2011 Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000292571900003
项目编号30800362
资助机构National Natural Science Foundation of China
引用统计
被引频次:42[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65535
专题中国药物依赖性研究所
北京大学医学部管理机构_医学部
作者单位Peking Univ, Natl Inst Drug Dependence, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Jiang, Wen-Gao,Li, Su-Xia,Zhou, Shuang-Jiang,et al. Chronic unpredictable stress induces a reversible change of PER2 rhythm in the suprachiasmatic nucleus[J]. BRAIN RESEARCH,2011,1399:25-32.
APA Jiang, Wen-Gao,Li, Su-Xia,Zhou, Shuang-Jiang,Sun, Yan,Shi, Jie,&Lu, Lin.(2011).Chronic unpredictable stress induces a reversible change of PER2 rhythm in the suprachiasmatic nucleus.BRAIN RESEARCH,1399,25-32.
MLA Jiang, Wen-Gao,et al."Chronic unpredictable stress induces a reversible change of PER2 rhythm in the suprachiasmatic nucleus".BRAIN RESEARCH 1399(2011):25-32.
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