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学科主题: 公共卫生
题名:
Effects of lutein and lycopene on carotid intima-media thickness in Chinese subjects with subclinical atherosclerosis: a randomised, double- blind, placebo- controlled trial
作者: Zou, Zhi-Yong1,2; Xu, Xian-Rong1; Lin, Xiao-Ming1; Zhang, Hua-Bin3; Xiao, Xin1; Ouyang, Li4; Huang, Yang-Mu1; Wang, Xun1; Liu, Ya-Qiong4
关键词: Atherosclerosis ; Ultrasonography ; Carotenoids ; Primary prevention
刊名: BRITISH JOURNAL OF NUTRITION
发表日期: 2014-02-14
DOI: 10.1017/S0007114513002730
卷: 111, 期:3, 页:474-480
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Nutrition & Dietetics
研究领域[WOS]: Nutrition & Dietetics
关键词[WOS]: LOS-ANGELES-ATHEROSCLEROSIS ; BETA-CAROTENE ; CARDIOVASCULAR-DISEASE ; ALPHA-TOCOPHEROL ; LUNG-CANCER ; RISK ; SUPPLEMENTATION ; PROGRESSION ; VEGETABLES ; ANTIOXIDANTS
英文摘要:

The aim of the present study was to evaluate the effects of lutein and lycopene supplementation on carotid artery intima-media thickness (CAIMT) in subjects with subclinical atherosclerosis. A total of 144 subjects aged 45-68 years were recruited from local communities. All the subjects were randomly assigned to receive 20 mg lutein/d (n 48), 20 mg lutein/d + 20 mg lycopene/d (n 48) or placebo (n 48) for 12 months. CAIMT was measured using Doppler ultrasonography at baseline and after 12 months, and serum lutein and lycopene concentrations were determined using HPLC. Serum lutein concentrations increased significantly from 0.34 to 1.96 mu mol/l in the lutein group (P<0.001) and from 0.35 to 1.66 mu mol/l in the combination group (P<0.001). Similarly, serum lycopene concentrations increased significantly from 0.18 to 0.71 mu mol/l in the combination group at month 12 (P<0.001), whereas no significant change was observed in the placebo group. The mean values of CAIMT decreased significantly by 0.035mm (P=0.042) and 0.073mm (P<0.001) in the lutein and combination groups at month 12, respectively. The change in CAIMT was inversely associated with the increase in serum lutein concentrations (P<0.05) in both the active treatment groups and with that in serum lycopene concentrations (beta = -0.342, P=0.031) in the combination group. Lutein and lycopene supplementation significantly increased the serum concentrations of lutein and lycopene with a decrease in CAIMT being associated with both concentrations. In addition, the combination of lutein and lycopene supplementation was more effective than lutein alone for protection against the development of CAIMT in Chinese subjects with subclinical atherosclerosis, and further studies are needed to confirm whether synergistic effects of lutein and lycopene exist.

语种: 英语
所属项目编号: NSFC-30972472
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000332451700011
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65536
Appears in Collections:北京大学公共卫生学院_期刊论文

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作者单位: 1.Peking Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Beijing 100191, Peoples R China
2.Peking Univ, Inst Child & Adolescent Hlth, Sch Publ Hlth, Beijing 100191, Peoples R China
3.Peking Univ, Hosp 3, Dept Ultrasound Diagnoses, Beijing 100191, Peoples R China
4.Peking Univ, Sch Publ Hlth, Cent Lab, Beijing 100191, Peoples R China

Recommended Citation:
Zou, Zhi-Yong,Xu, Xian-Rong,Lin, Xiao-Ming,et al. Effects of lutein and lycopene on carotid intima-media thickness in Chinese subjects with subclinical atherosclerosis: a randomised, double- blind, placebo- controlled trial[J]. BRITISH JOURNAL OF NUTRITION,2014,111(3):474-480.
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