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学科主题临床医学
Meta-Analysis of the Effect of Statins on Renal Function
Geng, Qiang; Ren, Jingyi; Song, Junxian; Li, Sufang; Chen, Hong
刊名AMERICAN JOURNAL OF CARDIOLOGY
2014-08-15
DOI10.1016/j.amjcard.2014.05.033
114期:4页:562-570
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cardiac & Cardiovascular Systems
研究领域[WOS]Cardiovascular System & Cardiology
关键词[WOS]DISEASE ; PROGRESSION ; OUTCOMES
英文摘要

Statins can significantly improve the lipid profile and reduce cardiovascular events. However, beneficial effects of statins on renal function are still controversial. PubMed, the Cochrane Central Register of Controlled Trials, Web of Knowledge, and ClinicalTrials.gov Web sites were searched for randomized controlled trials. The selected studies reported renal function during treatment with statins and control. Forty-one studies with a total of 88,523 participants were included in this analysis. Compared with statins, placebo group had significantly decreased estimated glomerular filtration rate (eGFR): the standardized mean difference (SMD) of eGFR in change from baseline was 0.15 (95% confidence interval [CI] 0.07 to 0.23, p = 0.0004) in patients with eGFR >60 ml/min and 0.09 (95% CI 0.01 to 0.17, p = 0.02) in patients with eGFR 30 to 60 ml/min. Compared with placebo, statin group had significantly greater reduction of proteinuria: the SMD of proteinuria in change from baseline was -1.12 (95% CI -1.95 to -0.30, p = 0.008) in patients with urinary protein excretion 30 to 300 mg/day and -0.77 (95% CI -1.35 to -0.18, p = 0.01) in patients with urinary protein excretion > 300 mg/day. eGFR was significantly greater with high-intensity statins than with moderate-intensity statins (SMD 0.12, 95% CI 0.08 to 0.16, p = 0.00001). Placebo group had significantly decreased eGFR for 1 to 3 years (SMD 0.05, 95% CI 0.02 to 0.08, p = 0.003) and >3 years (SMD 0.14, 95% CI 0.04 to 0.25, p = 0.007) of statin therapy. The beneficial effect of statins on renal function may be dosage related and duration dependent. In conclusion, statins appear to decrease the rate of reduction of eGFR and slow the progression of pathologic proteinuria moderately. (C) 2014 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000340442600010
项目编号30570712 ; 81070179
资助机构National Natural Science Foundation - national natural science fund committee (China)
引用统计
被引频次:27[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65539
专题北京大学第二临床医学院_心血管内科
作者单位Peking Univ, Peoples Hosp, Dept Cardiol, Beijing, Peoples R China
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GB/T 7714
Geng, Qiang,Ren, Jingyi,Song, Junxian,et al. Meta-Analysis of the Effect of Statins on Renal Function[J]. AMERICAN JOURNAL OF CARDIOLOGY,2014,114(4):562-570.
APA Geng, Qiang,Ren, Jingyi,Song, Junxian,Li, Sufang,&Chen, Hong.(2014).Meta-Analysis of the Effect of Statins on Renal Function.AMERICAN JOURNAL OF CARDIOLOGY,114(4),562-570.
MLA Geng, Qiang,et al."Meta-Analysis of the Effect of Statins on Renal Function".AMERICAN JOURNAL OF CARDIOLOGY 114.4(2014):562-570.
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