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Galactosylated chitosan nanoparticles for hepatocyte-targeted delivery of oridonin
Zheng, Dandan; Duan, Cunxian; Zhang, Dianrui1; Jia, Lejiao; Liu, Guangpu; Liu, Yue; Wang, Feihu; Li, Caiyun; Guo, Hejian; Zhang, Qiang2
关键词Galactosylated chitosan Nanoparticles Oridonin Tumor targeting
刊名INTERNATIONAL JOURNAL OF PHARMACEUTICS
2012-10-15
DOI10.1016/j.ijpharm.2012.06.039
436期:1-2页:379-386
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pharmacology & Pharmacy
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]GRAFTED-PEGYLATED-CHITOSAN ; TISSUE DISTRIBUTION ; ASIALOGLYCOPROTEIN RECEPTOR ; DRUG-DELIVERY ; HEPG2 CELLS ; NANOCAPSULES ; PACLITAXEL ; PHARMACOKINETICS ; PERMEABILITY ; ENHANCEMENT
英文摘要

In this study, oridonin-loaded nanoparticles coated with galactosylated chitosan (ORI-GC-NP) were prepared for tumor targeting and their characteristics were evaluated for the morphologies, particle size and zeta potential. Oridonin-loaded nanoparticles (ORI-NP) without galactosylated chitosan were prepared as a control. The entrapment efficiency of ORI-GC-NP and ORI-NP were 72.15% and 85.31%, respectively. The in vitro drug release behavior from nanoparticles displayed biphasic drug release pattern with initial burst release and consequently sustained release. Next, the pharmacokinetics and tissue distribution of ORI-GC-NP, ORI-NP and ORI solution were carried out. Pharmacokinetic analysis showed that ORI-GC-NP and ORI-NP could prolong the drug plasma levels compared with ORI solution. Meanwhile, the distribution of ORI-GC-NP to liver was higher than that of ORI-NP and free drug. In conclusion, ORI-GC-NP, as a promising intravenous drug delivery system for ORI, could be developed as an alternative to the conventional ORI preparations. (c) 2012 Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000308597600042
项目编号2009CB930300
资助机构National Basic Research Programme of China (973 Programme)
引用统计
被引频次:24[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65545
专题北京大学药学院
作者单位1.Shandong Univ, Dept Pharmaceut, Coll Pharm, Jinan 250012, Shandong, Peoples R China
2.Peking Univ, State Key Lab Nat & Biomimet Drugs, Sch Pharmaceut Sci, Beijing 100083, Peoples R China
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GB/T 7714
Zheng, Dandan,Duan, Cunxian,Zhang, Dianrui,et al. Galactosylated chitosan nanoparticles for hepatocyte-targeted delivery of oridonin[J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS,2012,436(1-2):379-386.
APA Zheng, Dandan.,Duan, Cunxian.,Zhang, Dianrui.,Jia, Lejiao.,Liu, Guangpu.,...&Zhang, Qiang.(2012).Galactosylated chitosan nanoparticles for hepatocyte-targeted delivery of oridonin.INTERNATIONAL JOURNAL OF PHARMACEUTICS,436(1-2),379-386.
MLA Zheng, Dandan,et al."Galactosylated chitosan nanoparticles for hepatocyte-targeted delivery of oridonin".INTERNATIONAL JOURNAL OF PHARMACEUTICS 436.1-2(2012):379-386.
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