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mGluR5 in the nucleus accumbens shell regulates morphine-associated contextual memory through reactive oxygen species signaling
Qi, Chong1; Wang, Xinjuan1; Ge, Feifei1; Li, Yijing1; Shen, Fang1; Wang, Junkai1; Cui, Cailian1
关键词Conditioned Place Preference (Cpp) Metabotropic Glutamate Receptor 5 (Mglur5) Morphine Nucleus Accumbens (Nac) Reactive Oxygen Species (Ros) Retrieval
刊名ADDICTION BIOLOGY
2015-09-01
DOI10.1111/adb.12222
20期:5页:927-940
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Substance Abuse
研究领域[WOS]Biochemistry & Molecular Biology ; Substance Abuse
关键词[WOS]Metabotropic Glutamate Receptors ; Cue-induced Reinstatement ; Protein-kinase-c ; Cocaine-seeking ; Mitochondrial Superoxide ; Induced Relapse ; In-vivo ; Rats ; Activation ; Addiction
英文摘要

Emerging evidence indicates that metabotropic glutamate receptor 5 (mGluR5) critically modulates drug and drug-related behaviors. However, the role of mGluR5 in the opiate-induced contextual memory remains unclear. Here, we found that microinfusion of the mGluR5 antagonist 3-((2-Methyl-1,3-thiazol-4-yl)ethynyl)pyridine (MTEP) into the nucleus accumbens (NAc) shell, but not into the core, significantly attenuated the expression of morphine conditioned place preference (CPP) in rats. Following the expression of morphine CPP, the protein level of membrane mGluR5 was selectively increased in the NAc shell. In primary striatal neurons, we observed that treatment with the mGluR5 agonist CHPG increased the phosphorylation level of extracellular signal-regulated kinase (ERK), which was dependent on the mGluR5-inositol-1,4,5-trisphosphate-reactive oxygen species (ROS) pathway. Moreover, the microinjection of the ROS scavenger Tempol into the NAc shell of rats blocked the expression of morphine CPP. Further, the administration of t-BOOH, a ROS donor, into the NAc shell rescued the retrieval impairment of morphine CPP produced by MTEP. Our previous study demonstrated that the expression of morphine CPP increased the phosphorylation of ERK selectively in the NAc shell. Thus, results of the present study suggest that mGluR5 in the NAc shell, but not in the core, is essential for the retrieval of morphine contextual memory, which is mediated at least in part, through the ROS/ERK signaling pathway. Uncovering the molecular basis of opiate contextual memory will benefit the development of new therapeutic approaches for the treatment of opiate addiction.

语种英语
WOS记录号WOS:000359670200007
通讯作者邮箱clcui@bjmu.edu.cn
项目编号31271163 ; 81221002
资助机构National Natural Science Foundation ; Science Fund for Creative Research Groups from the National Natural Science Foundation of China
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65546
专题北京大学基础医学院_神经生物学系
北京大学基础医学院
作者单位1.Peking Univ, Minist Educ, Key Lab Neurosci, Dept Neurobiol,Sch Basic Med Sci, Beijing 100191, Peoples R China
2.Peking Univ, Neurosci Res Inst, Natl Hlth & Family Planning Commiss, Beijing 100191, Peoples R China
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GB/T 7714
Qi, Chong,Wang, Xinjuan,Ge, Feifei,et al. mGluR5 in the nucleus accumbens shell regulates morphine-associated contextual memory through reactive oxygen species signaling[J]. ADDICTION BIOLOGY,2015,20(5):927-940.
APA Qi, Chong.,Wang, Xinjuan.,Ge, Feifei.,Li, Yijing.,Shen, Fang.,...&Cui, Cailian.(2015).mGluR5 in the nucleus accumbens shell regulates morphine-associated contextual memory through reactive oxygen species signaling.ADDICTION BIOLOGY,20(5),927-940.
MLA Qi, Chong,et al."mGluR5 in the nucleus accumbens shell regulates morphine-associated contextual memory through reactive oxygen species signaling".ADDICTION BIOLOGY 20.5(2015):927-940.
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