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学科主题: 精神卫生
题名:
Family-based association study of the NOTCH4 gene in schizophrenia using Japanese and Chinese samples
作者: Takahashi, S; Cui, YH; Kojima, T; Han, YH; Yu, SY; Tanabe, E; Yara, K; Matsuura, M; Matsushima, E; Nakayama, J; Arinami, T; Shen, YC; Faraone, SV; Tsuang, MT
关键词: schizophrenia ; early-onset schizophrenia ; negative symptoms ; NOTCH4 ; family-based association study
刊名: BIOLOGICAL PSYCHIATRY
发表日期: 2003-07-15
DOI: 10.1016/S0006-3223(03)01731-6
卷: 54, 期:2, 页:129-135
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences ; Psychiatry
研究领域[WOS]: Neurosciences & Neurology ; Psychiatry
关键词[WOS]: LINKAGE ANALYSIS ; GENOME SCAN ; HETEROGENEITY ; SUSCEPTIBILITY ; PHENOTYPES ; LOCUS ; 6P
英文摘要:

Background: A family based association study in a British sample found the NOTCH4 gene to be associated with schizophrenia; however, all six replication studies failed to confirm the finding.

Methods: We performed a family based association study of NOTCH4 and schizophrenia in 123 trios (16 Japanese and 107 Chinese). In addition to the original study′s polymorphisms, we examined four new single nucleotide polymorphisms (SNPs)-SNPs A, B, C and D-around SNP1 of the original study. We genotyped all samples for SNPs A-D and for SNP1 and (CTG)n of the original study.

Results: We found no significant associations between NOTCH4 and schizophrenia or its subtypes for all polymorphisms, regardless of gender. The finding remained negative when the Chinese sample was analyzed separately. Exploratory analyses suggested that SNP A may be associated with early-onset schizophrenia and that SNP1 may be associated with schizophrenia characterized by numerous negative symptoms.

Conclusions: NOTCH4 is not a significant susceptibility gene for schizophrenia when clinical heterogeneity is ignored; however, NOTCH4 may be associated with early-onset schizophrenia or schizophrenia with many negative symptoms, but these findings should be interpreted cautiously. (C) 2003 Society of Biological Psychiatry.

语种: 英语
WOS记录号: WOS:000184213800006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65549
Appears in Collections:北京大学精神卫生研究所_期刊论文

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作者单位: 1.Harvard Univ, Dept Psychiat, Massachusetts Mental Hlth Ctr, Sch Med, Boston, MA 02115 USA
2.Nihon Univ, Sch Med, Dept Neuropsychiat, Tokyo 102, Japan
3.Beijing Med Univ, Inst Mental Hlth, Beijing 100083, Peoples R China
4.Tokyo Med & Dent Univ, Fac Med, Dept Neuropsychiat, Tokyo 113, Japan
5.Univ Tsukuba, Inst Basic Med Sci, Dept Med Genet, Tsukuba, Ibaraki 305, Japan
6.Harvard Univ, Sch Publ Hlth, Harvard Inst Psychiat Epidemiol & Genet, Boston, MA 02115 USA
7.Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA

Recommended Citation:
Takahashi, S,Cui, YH,Kojima, T,et al. Family-based association study of the NOTCH4 gene in schizophrenia using Japanese and Chinese samples[J]. BIOLOGICAL PSYCHIATRY,2003,54(2):129-135.
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