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Family-based association study of the NOTCH4 gene in schizophrenia using Japanese and Chinese samples
Takahashi, S; Cui, YH; Kojima, T; Han, YH; Yu, SY; Tanabe, E; Yara, K; Matsuura, M; Matsushima, E; Nakayama, J; Arinami, T; Shen, YC; Faraone, SV; Tsuang, MT
关键词schizophrenia early-onset schizophrenia negative symptoms NOTCH4 family-based association study
刊名BIOLOGICAL PSYCHIATRY
2003-07-15
DOI10.1016/S0006-3223(03)01731-6
54期:2页:129-135
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences ; Psychiatry
研究领域[WOS]Neurosciences & Neurology ; Psychiatry
关键词[WOS]LINKAGE ANALYSIS ; GENOME SCAN ; HETEROGENEITY ; SUSCEPTIBILITY ; PHENOTYPES ; LOCUS ; 6P
英文摘要

Background: A family based association study in a British sample found the NOTCH4 gene to be associated with schizophrenia; however, all six replication studies failed to confirm the finding.

Methods: We performed a family based association study of NOTCH4 and schizophrenia in 123 trios (16 Japanese and 107 Chinese). In addition to the original study′s polymorphisms, we examined four new single nucleotide polymorphisms (SNPs)-SNPs A, B, C and D-around SNP1 of the original study. We genotyped all samples for SNPs A-D and for SNP1 and (CTG)n of the original study.

Results: We found no significant associations between NOTCH4 and schizophrenia or its subtypes for all polymorphisms, regardless of gender. The finding remained negative when the Chinese sample was analyzed separately. Exploratory analyses suggested that SNP A may be associated with early-onset schizophrenia and that SNP1 may be associated with schizophrenia characterized by numerous negative symptoms.

Conclusions: NOTCH4 is not a significant susceptibility gene for schizophrenia when clinical heterogeneity is ignored; however, NOTCH4 may be associated with early-onset schizophrenia or schizophrenia with many negative symptoms, but these findings should be interpreted cautiously. (C) 2003 Society of Biological Psychiatry.

语种英语
WOS记录号WOS:000184213800006
引用统计
被引频次:20[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65549
专题北京大学精神卫生研究所
作者单位1.Harvard Univ, Dept Psychiat, Massachusetts Mental Hlth Ctr, Sch Med, Boston, MA 02115 USA
2.Nihon Univ, Sch Med, Dept Neuropsychiat, Tokyo 102, Japan
3.Beijing Med Univ, Inst Mental Hlth, Beijing 100083, Peoples R China
4.Tokyo Med & Dent Univ, Fac Med, Dept Neuropsychiat, Tokyo 113, Japan
5.Univ Tsukuba, Inst Basic Med Sci, Dept Med Genet, Tsukuba, Ibaraki 305, Japan
6.Harvard Univ, Sch Publ Hlth, Harvard Inst Psychiat Epidemiol & Genet, Boston, MA 02115 USA
7.Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA
推荐引用方式
GB/T 7714
Takahashi, S,Cui, YH,Kojima, T,et al. Family-based association study of the NOTCH4 gene in schizophrenia using Japanese and Chinese samples[J]. BIOLOGICAL PSYCHIATRY,2003,54(2):129-135.
APA Takahashi, S.,Cui, YH.,Kojima, T.,Han, YH.,Yu, SY.,...&Tsuang, MT.(2003).Family-based association study of the NOTCH4 gene in schizophrenia using Japanese and Chinese samples.BIOLOGICAL PSYCHIATRY,54(2),129-135.
MLA Takahashi, S,et al."Family-based association study of the NOTCH4 gene in schizophrenia using Japanese and Chinese samples".BIOLOGICAL PSYCHIATRY 54.2(2003):129-135.
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