IR@PKUHSC  > 北京大学第二临床医学院
学科主题临床医学
Large animal models of human cauda equina injury and repair: evaluation of a novel goat model
Chen, Wen-tao1; Zhang, Pei-xun1; Xue, Feng1; Yin, Xiao-feng1; Qi, Cao-yuan2; Ma, Jun2; Chen, Bo1; Yu, You-lai1; Deng, Jiu-xu1; Jiang, Bao-guo1
关键词nerve regeneration spinal cord injury goat animal model radiography magnetic resonance imaging diffusion tensor imaging fiber bundle diagnosis injury physiology neuroimaging NSFC grants neural regeneration
刊名NEURAL REGENERATION RESEARCH
2015
DOI10.4103/1673-5374.150707
10期:1页:60-64
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cell Biology ; Neurosciences
资助者National Program on Key Basic Research Project of China (973 Program) ; Program for Innovative Research Team in University of Ministry of Education of China ; National Natural Science Foundation of China ; Program for New Century Excellent Talents in University of Ministry of Education of China ; Natural Science Foundation of Beijing of China ; National Program on Key Basic Research Project of China (973 Program) ; Program for Innovative Research Team in University of Ministry of Education of China ; National Natural Science Foundation of China ; Program for New Century Excellent Talents in University of Ministry of Education of China ; Natural Science Foundation of Beijing of China
研究领域[WOS]Cell Biology ; Neurosciences & Neurology
关键词[WOS]RAT SPINAL-CORD ; ELECTROMYOGRAPHY ; SURGERY
英文摘要

Previous animal studies of cauda equina injury have primarily used rat models, which display significant differences from humans. Furthermore, most studies have focused on electrophysiological examination. To better mimic the outcome after surgical repair of cauda equina injury, a novel animal model was established in the goat. Electrophysiological, histological and magnetic resonance imaging methods were used to evaluate the morphological and functional outcome after cauda equina injury and end-to-end suture. Our results demonstrate successful establishment of the goat experimental model of cauda equina injury. This novel model can provide detailed information on the nerve regenerative process following surgical repair of cauda equina injury.

语种英语
所属项目编号2014CB542200 ; IRT1201 ; 31271284 ; 31171150 ; 81171146 ; 30971526 ; 31040043 ; 31371210 ; 81372044 ; 31471144 ; BMU20110270 ; 7142164
资助者National Program on Key Basic Research Project of China (973 Program) ; Program for Innovative Research Team in University of Ministry of Education of China ; National Natural Science Foundation of China ; Program for New Century Excellent Talents in University of Ministry of Education of China ; Natural Science Foundation of Beijing of China ; National Program on Key Basic Research Project of China (973 Program) ; Program for Innovative Research Team in University of Ministry of Education of China ; National Natural Science Foundation of China ; Program for New Century Excellent Talents in University of Ministry of Education of China ; Natural Science Foundation of Beijing of China
WOS记录号WOS:000350098100018
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65550
专题北京大学第二临床医学院
作者单位1.Peking Univ, Peoples Hosp, Dept Trauma & Orthoped, Beijing 100871, Peoples R China
2.Capital Med Univ, Beijing Tian Tan Hosp, Dept Radiol, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Chen, Wen-tao,Zhang, Pei-xun,Xue, Feng,et al. Large animal models of human cauda equina injury and repair: evaluation of a novel goat model[J]. NEURAL REGENERATION RESEARCH,2015,10(1):60-64.
APA Chen, Wen-tao.,Zhang, Pei-xun.,Xue, Feng.,Yin, Xiao-feng.,Qi, Cao-yuan.,...&Jiang, Bao-guo.(2015).Large animal models of human cauda equina injury and repair: evaluation of a novel goat model.NEURAL REGENERATION RESEARCH,10(1),60-64.
MLA Chen, Wen-tao,et al."Large animal models of human cauda equina injury and repair: evaluation of a novel goat model".NEURAL REGENERATION RESEARCH 10.1(2015):60-64.
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