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学科主题: 临床医学
题名:
Large animal models of human cauda equina injury and repair: evaluation of a novel goat model
作者: Chen, Wen-tao1; Zhang, Pei-xun1; Xue, Feng1; Yin, Xiao-feng1; Qi, Cao-yuan2; Ma, Jun2; Chen, Bo1; Yu, You-lai1; Deng, Jiu-xu1; Jiang, Bao-guo1
关键词: nerve regeneration ; spinal cord injury ; goat ; animal model ; radiography ; magnetic resonance imaging ; diffusion tensor imaging ; fiber bundle ; diagnosis ; injury ; physiology ; neuroimaging ; NSFC grants ; neural regeneration
刊名: NEURAL REGENERATION RESEARCH
发表日期: 2015
DOI: 10.4103/1673-5374.150707
卷: 10, 期:1, 页:60-64
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cell Biology ; Neurosciences
研究领域[WOS]: Cell Biology ; Neurosciences & Neurology
关键词[WOS]: RAT SPINAL-CORD ; ELECTROMYOGRAPHY ; SURGERY
英文摘要:

Previous animal studies of cauda equina injury have primarily used rat models, which display significant differences from humans. Furthermore, most studies have focused on electrophysiological examination. To better mimic the outcome after surgical repair of cauda equina injury, a novel animal model was established in the goat. Electrophysiological, histological and magnetic resonance imaging methods were used to evaluate the morphological and functional outcome after cauda equina injury and end-to-end suture. Our results demonstrate successful establishment of the goat experimental model of cauda equina injury. This novel model can provide detailed information on the nerve regenerative process following surgical repair of cauda equina injury.

语种: 英语
所属项目编号: 2014CB542200 ; IRT1201 ; 31271284 ; 31171150 ; 81171146 ; 30971526 ; 31040043 ; 31371210 ; 81372044 ; 31471144 ; BMU20110270 ; 7142164
项目资助者: National Program on Key Basic Research Project of China (973 Program) ; Program for Innovative Research Team in University of Ministry of Education of China ; National Natural Science Foundation of China ; Program for New Century Excellent Talents in University of Ministry of Education of China ; Natural Science Foundation of Beijing of China
WOS记录号: WOS:000350098100018
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65550
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: 1.Peking Univ, Peoples Hosp, Dept Trauma & Orthoped, Beijing 100871, Peoples R China
2.Capital Med Univ, Beijing Tian Tan Hosp, Dept Radiol, Beijing, Peoples R China

Recommended Citation:
Chen, Wen-tao,Zhang, Pei-xun,Xue, Feng,et al. Large animal models of human cauda equina injury and repair: evaluation of a novel goat model[J]. NEURAL REGENERATION RESEARCH,2015,10(1):60-64.
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