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学科主题: 临床医学
题名:
Evaluation of an in situ chemically crosslinked hydrogel as a long-term vitreous substitute material
作者: Tao, Yong1,2; Tong, Xinming3; Zhang, Yan1,2; Lai, Jingjing3; Huang, Yanbin3; Jiang, Yan-Rong1,2; Guo, Bao-Hua3
关键词: Hydrogel ; Vitreous substitute ; Rabbit ; Biocompatibility
刊名: ACTA BIOMATERIALIA
发表日期: 2013-02-01
DOI: 10.1016/j.actbio.2012.09.026
卷: 9, 期:2, 页:5022-5030
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Engineering, Biomedical ; Materials Science, Biomaterials
研究领域[WOS]: Engineering ; Materials Science
关键词[WOS]: PARS-PLANA VITRECTOMY ; INTRAOCULAR-LENS IMPLANTATION ; RETINAL-DETACHMENT ; POLY(1-VINYL-2-PYRROLIDINONE) ; PHACOEMULSIFICATION ; MACROMOLECULES ; RABBIT ; BODY ; EYE
英文摘要:

Currently there is no material that can be used as a long-term vitreous substitute, and this remains an unmet clinical need in ophthalmology. In this study, we developed an injectable, in situ chemically crosslinked hydrogel system and evaluated it in a rabbit model. The system consisted of two components, both based on multi-functional poly(ethylene glycol) (PEG) but with complementarily reactive end groups of thiol and active vinyl groups, respectively. The two components are mixed and injected as a solution mixture, react in vivo via the Michael addition route and form a chemically crosslinked hydrogel in situ. The linkages between the end groups and the backbone PEG chains are specially designed to ensure that the final network structure is hydrolysis-resistant. In the rabbit study and with an optimized operation protocol, we demonstrated that the hydrogel indeed formed in situ after injection, and remained transparent and stable during the study period of 9 months without significant adverse reactions. In addition, the hydrogel formed in situ showed rheological properties very similar to the natural vitreous. Therefore, our study demonstrated that this in situ chemically crosslinked PEG gel system is suitable as a potential long-term vitreous substitute. Crown Copyright (C) 2012 Published by Elsevier Ltd. on behalf of Acta Materialia Inc. All rights reserved.

语种: 英语
所属项目编号: Z08000303220801 ; 20100001110073 ; 20110001110042 ; 30901639 ; 2009B04 ; 7112142
项目资助者: Science and Technology Project of Beijing ; Research Fund for the Doctoral Program of Higher Education of China ; National Natural Science Foundation of China ; Beijing Novel Program ; Beijing Natural Science Foundation
WOS记录号: WOS:000315170800009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65553
Appears in Collections:北京大学第二临床医学院_眼科_期刊论文

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作者单位: 1.Minist Educ, Key Lab Vis Loss & Restorat, Beijing, Peoples R China
2.Tsinghua Univ, Dept Chem Engn, Beijing 100084, Peoples R China
3.Peking Univ, Dept Ophthalmol, Peoples Hosp, Beijing 100871, Peoples R China

Recommended Citation:
Tao, Yong,Tong, Xinming,Zhang, Yan,et al. Evaluation of an in situ chemically crosslinked hydrogel as a long-term vitreous substitute material[J]. ACTA BIOMATERIALIA,2013,9(2):5022-5030.
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