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Evaluation of an in situ chemically crosslinked hydrogel as a long-term vitreous substitute material
Tao, Yong1,2; Tong, Xinming3; Zhang, Yan1,2; Lai, Jingjing3; Huang, Yanbin3; Jiang, Yan-Rong1,2; Guo, Bao-Hua3
关键词Hydrogel Vitreous substitute Rabbit Biocompatibility
刊名ACTA BIOMATERIALIA
2013-02-01
DOI10.1016/j.actbio.2012.09.026
9期:2页:5022-5030
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Engineering, Biomedical ; Materials Science, Biomaterials
研究领域[WOS]Engineering ; Materials Science
关键词[WOS]PARS-PLANA VITRECTOMY ; INTRAOCULAR-LENS IMPLANTATION ; RETINAL-DETACHMENT ; POLY(1-VINYL-2-PYRROLIDINONE) ; PHACOEMULSIFICATION ; MACROMOLECULES ; RABBIT ; BODY ; EYE
英文摘要

Currently there is no material that can be used as a long-term vitreous substitute, and this remains an unmet clinical need in ophthalmology. In this study, we developed an injectable, in situ chemically crosslinked hydrogel system and evaluated it in a rabbit model. The system consisted of two components, both based on multi-functional poly(ethylene glycol) (PEG) but with complementarily reactive end groups of thiol and active vinyl groups, respectively. The two components are mixed and injected as a solution mixture, react in vivo via the Michael addition route and form a chemically crosslinked hydrogel in situ. The linkages between the end groups and the backbone PEG chains are specially designed to ensure that the final network structure is hydrolysis-resistant. In the rabbit study and with an optimized operation protocol, we demonstrated that the hydrogel indeed formed in situ after injection, and remained transparent and stable during the study period of 9 months without significant adverse reactions. In addition, the hydrogel formed in situ showed rheological properties very similar to the natural vitreous. Therefore, our study demonstrated that this in situ chemically crosslinked PEG gel system is suitable as a potential long-term vitreous substitute. Crown Copyright (C) 2012 Published by Elsevier Ltd. on behalf of Acta Materialia Inc. All rights reserved.

语种英语
WOS记录号WOS:000315170800009
项目编号Z08000303220801 ; 20100001110073 ; 20110001110042 ; 30901639 ; 2009B04 ; 7112142
资助机构Science and Technology Project of Beijing ; Research Fund for the Doctoral Program of Higher Education of China ; National Natural Science Foundation of China ; Beijing Novel Program ; Beijing Natural Science Foundation
引用统计
被引频次:23[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65553
专题北京大学第二临床医学院_眼科
作者单位1.Minist Educ, Key Lab Vis Loss & Restorat, Beijing, Peoples R China
2.Tsinghua Univ, Dept Chem Engn, Beijing 100084, Peoples R China
3.Peking Univ, Dept Ophthalmol, Peoples Hosp, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Tao, Yong,Tong, Xinming,Zhang, Yan,et al. Evaluation of an in situ chemically crosslinked hydrogel as a long-term vitreous substitute material[J]. ACTA BIOMATERIALIA,2013,9(2):5022-5030.
APA Tao, Yong.,Tong, Xinming.,Zhang, Yan.,Lai, Jingjing.,Huang, Yanbin.,...&Guo, Bao-Hua.(2013).Evaluation of an in situ chemically crosslinked hydrogel as a long-term vitreous substitute material.ACTA BIOMATERIALIA,9(2),5022-5030.
MLA Tao, Yong,et al."Evaluation of an in situ chemically crosslinked hydrogel as a long-term vitreous substitute material".ACTA BIOMATERIALIA 9.2(2013):5022-5030.
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