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学科主题: 基础医学
题名:
The attenuation effect of 3,4-dihydroxy-phenyl lactic acid and salvianolic acid B on venular thrombosis induced in rat mesentery by photochemical reaction
作者: Wang, Fang2; Liu, Yu-Ying2; Liu, Lian-Yi2; Zeng, Qing-Jiang2; Wang, Chuan-She1,2; Sun, Kai2; Yang, Ji-Ying2; Guo, Jun2; Fan, Jing-Yu2; Han, Jing-Yan1,2
关键词: Antioxidant ; adhesion molecule ; mast cell degranulation ; Salvia miltiorrhiza ; thrombosis
刊名: CLINICAL HEMORHEOLOGY AND MICROCIRCULATION
发表日期: 2009
DOI: 10.3233/CH-2009-1180
卷: 42, 期:1, 页:7-18
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Hematology ; Peripheral Vascular Disease
研究领域[WOS]: Hematology ; Cardiovascular System & Cardiology
关键词[WOS]: NEUTROPHIL-PLATELET ADHESION ; P-SELECTIN ; MICROCIRCULATORY DISTURBANCE ; ISCHEMIA-REPERFUSION ; ARTERIAL THROMBOSIS ; INTEGRIN CD11B/CD18 ; CARDIOTONIC PILLS ; ENDOTHELIAL-CELLS ; MAST-CELLS ; MODEL
英文摘要:

3,4-dihydroxy-phenyl lactic acid (DLA) and salvianolic acid B (SAB) are two major water-soluble components of Salvia miltiorrhiza (SM). Previous works have revealed the ability of DLA and SAB to scavenge oxygen free radicals, inhibiting the expression of adhesion molecules CD11b/CD18 in neutrophil. Cardiotonic pills (CP), which is a traditional Chinese medicine compound preparation containing DLA and SAB, was found to inhibit venular thrombosis induced by photochemical reaction (PR) in rat mesentery. The present study addressed the effect of DLA and SAB on PR-induced thrombosis in rat mesentery by utilizing a microcirculation dynamic viewing system. The result demonstrated that both DLA and SAB delayed thrombus-initiation time, while DLA also prolonged thrombus half-size time. The experiments explored the mechanism underlying that the dihydrorhodamine 123 (DHR) fluorescence in the mesenteric venular walls after PR challenge was diminished by pretreatment with either DLA or SAB, the expression of CD18 in neutrophils elicited by PR was depressed by administration of DLA, while mast cell degranulation in rat mesentery induced by PR was damped by SAB. The antioxidant potential of the two substances is likely to be responsible for their most beneficial effects on thrombosis, through either directly scavenging the peroxides produced and/or indirectly depressing the expression of adhesion molecules in neutrophil.

语种: 英语
项目资助者: Tianjin Tasly group, Tianjin, China
WOS记录号: WOS:000265997600002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65556
Appears in Collections:基础医学院_期刊论文

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作者单位: 1.Peking Univ, Sch Basic Med Sci, Dept Integrat Chinese & Western Med, Beijing 100083, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Tasly Microcirculat Res Ctr, Beijing 100083, Peoples R China

Recommended Citation:
Wang, Fang,Liu, Yu-Ying,Liu, Lian-Yi,et al. The attenuation effect of 3,4-dihydroxy-phenyl lactic acid and salvianolic acid B on venular thrombosis induced in rat mesentery by photochemical reaction[J]. CLINICAL HEMORHEOLOGY AND MICROCIRCULATION,2009,42(1):7-18.
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