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学科主题: 临床医学
题名:
Hyperglycemia and Blood Pressure Treatment Goal: A Cross Sectional Survey of 18350 Patients with Type 2 Diabetes in 77 Tertiary Hospitals in China
作者: Ji, Linong1; Zhi, Xinyue2; Lu, Juming3; Guo, Xiaohui4; Yang, Wenying5; Jia, Weiping6; Zou, Dajin7; Zhou, Zhiguang8; Ji, Qiuhe9; Zhu, Dalong10; Shi, Lixin11; Weng, Jianping12
刊名: PLOS ONE
发表日期: 2014-08-14
DOI: 10.1371/journal.pone.0103507
卷: 9, 期:8
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: RENIN-ANGIOTENSIN SYSTEM ; LOW-DENSITY-LIPOPROTEIN ; CORONARY-ARTERY-DISEASE ; METABOLIC SYNDROME ; GLUCOSE CONTROL ; RISK-FACTORS ; HEART-DISEASE ; MELLITUS ; HYPERTENSION ; COMPLICATIONS
英文摘要:

Objective: To investigate the association of hyperglycemia with blood pressure control goal in the patients with type 2 diabetes (T2D) cared by tertiary hospitals in China.

Study Design and Methods: A cross sectional survey of 29442 patients was conducted in 77 tertiary hospitals in 4 major cities in China in 2011 and 18350 of them without known hypertension were used in the analysis. Univariable and multivariable logistic regression analysis stratified on cities and hospitals was performed to obtain odds ratio of factors of interest for achievement of the blood pressure treatment goal, i.e., 140/80 mmHg as recommended by American Diabetes Association (ADA). Sensitivity analysis was performed after re-inclusion of 11902 patients with diagnosed hypertension. Findings from were further replicated in patients with T2D recruited using the same protocol from tertiary hospitals located in other central cities in China.

Results: The mean age was 58.2 (SD: 11.3) years and 53.3% were male, with a median of 4 years of disease duration. A total of 12129 patients (58.2%) did not achieve the ADA recommended goal for BP control. After adjusting for covariables, hyperglycemia was associated with failure to achieve the BP goal (OR of HbA1c at 6.5%-6.9% vs. <6.0%: 1.22, 95%CI: 1.08 to 1.39; OR of 7.0%-7.0% vs. <6.0%: 1.37, 1.21 to 1.54 and OR of >= 8.0% vs. <6.0%: 1.22, 95%CI: 1.08 to 1.38). The sensitivity analysis and the replication analysis showed similar results.

Conclusions: Hyperglycemia defined as HbA1c >= 6.5% increased the risk of failure to achieve the BP goal in T2D patients.

语种: 英语
项目资助者: Novo Nordisk, China
WOS记录号: WOS:000341017000015
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65560
Appears in Collections:北京大学第二临床医学院_内分泌科_期刊论文

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作者单位: 1.Beijing Mil Command, Gen Hosp, Dept Endocrinol, Beijing, Peoples R China
2.Sino Japan Friendship Hosp, Dept Endocrinol, Beijing, Peoples R China
3.Peking Univ, Peoples Hosp, Dept Endocrinol, Beijing, Peoples R China
4.Tianjin Med Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Tianjin, Peoples R China
5.Peking Univ, Hosp 1, Dept Endocrinol, Beijing 100871, Peoples R China
6.Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 6, Dept Endocrinol, Shanghai, Peoples R China
7.Cent S Univ, Xiangya Hosp 2, Dept Endocrinol, Changsha, Hunan, Peoples R China
8.4th Mil Med Univ, Xijing Hosp, Dept Endocrinol, Xian, Peoples R China
9.Nanjing Drum Tower Hosp, Dept Endocrinol, Nanjing, Jiangsu, Peoples R China
10.Sun Yat Sen Univ, Affiliated Hosp 3, Guangzhou 510275, Guangdong, Peoples R China
11.Changhai Hosp Shanghai, Dept Endocrinol, Shanghai, Peoples R China
12.Hosp Guiyang Med Univ, Dept Endocrinol, Guiyang, Peoples R China

Recommended Citation:
Ji, Linong,Zhi, Xinyue,Lu, Juming,et al. Hyperglycemia and Blood Pressure Treatment Goal: A Cross Sectional Survey of 18350 Patients with Type 2 Diabetes in 77 Tertiary Hospitals in China[J]. PLOS ONE,2014,9(8).
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