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学科主题临床医学
Double-blind, multicenter, active-controlled, randomized clinical trial to assess the safety and efficacy of orally administered nicorandil in patients with stable angina pectoris in China
Zhu, Wen-Ling; Shan, Yuan-Dong; Guo, Jing-Xuan; Wei, Jia-Ping; Yang, Xin-Chun; Li, Tian-De; Jia, San-Qing; He, Qing; Chen, Jun-Zhu; Wu, Zong-Gui; Li, Zhan-Quan; You, Kai
关键词angina pectoris China exercise tolerance test isosorbide mononitrate nicorandil
刊名CIRCULATION JOURNAL
2007-06-01
71期:6页:826-833
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cardiac & Cardiovascular Systems
研究领域[WOS]Cardiovascular System & Cardiology
关键词[WOS]ACUTE MYOCARDIAL-INFARCTION ; 2-NICOTINAMIDOETHYL NITRATE ; INTRAVENOUS NICORANDIL ; CORONARY-ARTERIES ; REPERFUSION ; IMPACT ; MANAGEMENT ; ISCHEMIA ; THERAPY
英文摘要

Background The efficacy and safety of nicorandil were evaluated in Chinese patients with stable angina pectoris (AP) in a double-blind, multicenter, active-controlled, randomized clinical trial. Methods and Results After a 2-week washout period, 232 patients with stable AP were randomized to receive either nicorandil (5 mg tid; 115 patients) or isosorbide mononitrate (ISMN: 20 mg bid; 117 patients) for 2 weeks. Exercise capacity, number of weekly anginal attacks, nitroglycerin (NTG) consumption, and safety were evaluated. Nicorandil and ISMN significantly prolonged the time to I mm ST-segment depression in an exercise tolerance test. Both drugs improved the total exercise time and the time to onset of chest pain. There was no significant difference between the 2 groups. Nicorandil significantly decreased the number of anginal attacks and NTG consumption. ISMN decreased the number of anginal attacks significantly; however, there was no significance in NTG consumption, and the ratio of anginal attack reduction was at least 50% was significantly higher with nicorandil. Nicorandil was well tolerated and there was no safety profile difference compared with ISMN. Thus, nicorandil may have equivalent or better antianginal effect than ISMN. Conclusions Nicorandil is beneficial as treatment for AP.

语种英语
WOS记录号WOS:000246882800004
引用统计
被引频次:17[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65564
专题北京大学第三临床医学院_心血管内科
作者单位1.Beijing Union Med Coll Hosp, Div Cardiol, Beijing 100730, Peoples R China
2.Beijing Union Med Coll Hosp, Res Ctr Clin Pharmacol, Beijing 100730, Peoples R China
3.Peking Univ, Div Cardiol, Hosp 3, Beijing 100871, Peoples R China
4.Capital Univ, Beijing Chao Yan Hosp, Div Cardiol, Beijing, Peoples R China
5.Peoples Liberat Army Gen Hosp, Div Cardiol, Beijing, Peoples R China
6.Capital Univ Med Sci, Div Cardiol, Beijing Friendship Hosp, Beijing, Peoples R China
7.Shanghai Changzheng Hosp, Div Cardiol, Shanghai, Peoples R China
8.Capital Univ, Xuan Wu Hosp, Div Cardiol, Beijing, Peoples R China
9.Beijing Hosp, Div Cardiol, Beijing, Peoples R China
10.Zhen Jiang Univ, Hosp 1, Div Cardiol, Hangzhou, Peoples R China
11.Ren Min Hosp Liao Ning Prov, Div Cardiol, Shenyang, Peoples R China
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Zhu, Wen-Ling,Shan, Yuan-Dong,Guo, Jing-Xuan,et al. Double-blind, multicenter, active-controlled, randomized clinical trial to assess the safety and efficacy of orally administered nicorandil in patients with stable angina pectoris in China[J]. CIRCULATION JOURNAL,2007,71(6):826-833.
APA Zhu, Wen-Ling.,Shan, Yuan-Dong.,Guo, Jing-Xuan.,Wei, Jia-Ping.,Yang, Xin-Chun.,...&You, Kai.(2007).Double-blind, multicenter, active-controlled, randomized clinical trial to assess the safety and efficacy of orally administered nicorandil in patients with stable angina pectoris in China.CIRCULATION JOURNAL,71(6),826-833.
MLA Zhu, Wen-Ling,et al."Double-blind, multicenter, active-controlled, randomized clinical trial to assess the safety and efficacy of orally administered nicorandil in patients with stable angina pectoris in China".CIRCULATION JOURNAL 71.6(2007):826-833.
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