学科主题临床医学
FOXP3 gene polymorphism is associated with hepatitis B-related hepatocellular carcinoma in China
Chen, YanHui1,2; Zhang, HengHui1,2; Liao, WeiJia3; Zhou, JinXue4; He, GaiXia1,2; Xie, XingWang1,2; Fei, Ran1,2; Qin, LiLing3; Wei, Lai1,2; Chen, HongSong1,2
关键词Carcinoma Hepatocellular Hepatitis B Chronic Gene polymorphism FOXP3
刊名JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
2013-06-10
DOI10.1186/1756-9966-32-39
32
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]REGULATORY T-CELLS ; TRANSCRIPTION FACTOR FOXP3 ; BREAST-CANCER ; DISEASE PROGRESSION ; TUMOR ; EXPRESSION ; SURVIVAL ; VIRUS
英文摘要

Background: Previous evidence has shown that the FOXP3 gene was involved in the pathogenesis of several tumors; however, the correlation between single nucleotide polymorphisms (SNPs) in the FOXP3 gene and the susceptibility to hepatitis B-related hepatocellular carcinoma (HCC) remains unclear.

Methods: We analyzed two SNPs in the FOXP3 gene, rs2280883 and rs3761549, in 392 patients with HCC, 344 patients with chronic hepatitis B (CHB) and 372 matched healthy controls. Genotyping was performed by MALDI-TOF Mass Spectrometry for all donors.

Results: Compared to healthy controls, HCC patients had higher frequencies of the TT genotype (79.6%) at rs2280883 and the CC genotype (77.6%) at rs3761549 of the FOXP3 gene; CHB patients also had higher frequencies of the TT genotype (74.1%) at rs2280883 and the CC genotype (74.6%) at rs3761549. There were no significant differences in the distribution of FOXP3 genotypes between CHB donors and HCC donors. The TT genotype at rs2280883 was more frequent in patients with HCC than healthy donors (P = 0.01), but no significant difference was observed in this genotype between CHB and healthy donors (P = 0.479). C allele frequency at rs3761549 was higher in HCC patients than healthy donors (P = 0.03), but distribution of this allele was not significantly different between CHB patients and healthy donors (P = 0.11). Stratified analysis showed that the CC genotype at rs3761549 was significantly associated with a high incidence of portal vein tumor thrombus (P = 0.02) and that the TT/CT genotype at rs3761549 was significantly associated with an increased rate of tumor recurrence in HCC patients (P = 0.001).

Conclusions: Our results suggested that the FOXP3 gene polymorphisms at rs2280883 and rs3761549 may be associated with hepatitis B-related HCC. At rs3761549, the CC genotype and the TT/CT genotype were associated with a high incidence of portal vein tumor thrombus and tumor recurrence, respectively.

语种英语
WOS记录号WOS:000322971600001
项目编号91029741 ; 81001072 ; 2012ZX10002011-006 ; 5112032 ; 122102310056 ; 132102310182
资助机构National Natural Science Foundation of China ; National Key Sci-Tech Special Project of China ; Beijing Natural science foundation ; Magnitude science and technology projects of Henan province
引用统计
被引频次:19[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65565
专题北京大学第二临床医学院_北京大学肝病研究所
作者单位1.Peking Univ, Inst Hepatol, Peking Univ Peoples Hosp, Beijing 100044, Peoples R China
2.Beijing Key Lab Hepatitis C & Immunotherapy Liver, Beijing 100044, Peoples R China
3.Henan Tumor Hosp, Dept Hepatobiliary & Pancreat Surg, Zhengzhou 450008, Peoples R China
4.Guilin Med Univ, Affiliated Hosp, Guilin 541004, Peoples R China
推荐引用方式
GB/T 7714
Chen, YanHui,Zhang, HengHui,Liao, WeiJia,et al. FOXP3 gene polymorphism is associated with hepatitis B-related hepatocellular carcinoma in China[J]. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH,2013,32.
APA Chen, YanHui.,Zhang, HengHui.,Liao, WeiJia.,Zhou, JinXue.,He, GaiXia.,...&Chen, HongSong.(2013).FOXP3 gene polymorphism is associated with hepatitis B-related hepatocellular carcinoma in China.JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH,32.
MLA Chen, YanHui,et al."FOXP3 gene polymorphism is associated with hepatitis B-related hepatocellular carcinoma in China".JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH 32(2013).
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