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学科主题: 公共卫生
题名:
Increased Arterial Stiffness in Subjects with Pre-diabetes among Middle Aged Population in Beijing, China
作者: Shen Li1; Zhang Yan Ge2; Liu Min1; Wu Liu Xin2; Qiang Dong Chang2; Sun Xue Lei2; Liu Lin2; Jiang Yuan Yuan2
关键词: Pre-diabetes ; Vascular stiffness ; Arterial stiffness
刊名: BIOMEDICAL AND ENVIRONMENTAL SCIENCES
发表日期: 2013-09-01
DOI: 10.3967/0895-3988.2013.09.002
卷: 26, 期:9, 页:717-725
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Environmental Sciences ; Public, Environmental & Occupational Health
研究领域[WOS]: Environmental Sciences & Ecology ; Public, Environmental & Occupational Health
关键词[WOS]: PULSE-WAVE VELOCITY ; IMPAIRED GLUCOSE-TOLERANCE ; TYPE-2 DIABETIC-PATIENTS ; PREDICTS CARDIOVASCULAR MORTALITY ; COHORT STUDY-CVD ; FASTING GLUCOSE ; METABOLIC SYNDROME ; VASCULAR FUNCTION ; RISK-FACTORS ; DIAGNOSIS
英文摘要:

Objective To investigate the relationship between arterial stiffness and pre-diabetes when assessed by the new glycosylated hemoglobin A(1c) (HbA(1c)) 5.7%-6.4% criterion or by impaired fasting glucose in middle aged Chinese.

Methods 1122 adults aged 55 years or younger in the health examination centers for physical check-ups were enrolled in the two large-sized Tertiary Comprehensive Hospitals in Beijing from June 2011 to June 2012 after excluding those who previously had been diagnosed or treated as diabetes or cardiovascular disease. Subjects with a diagnosis of pre-diabetes according to impaired fasting glucose (IFG) (fasting plasma glucose (FPG) levels at 5.6-6.9 mmol/L), HbA(1c) levels at 5.7%-6.4%, or both, were classified into four groups for observation: (1) Normoglycaemia (HbA(1c)< 5.7% and FPG < 5.6 mmol/L); (2) IFG alone (FPG levels at 5.6-6.9 mmol/L and HbA(1c)< 5.7%); (3) HbA(1c) 5.7%-6.4% alone (HbA1c levels at 5.7%-6.4% and FPG < 5.6 mmol/L); and (4) both HbA(1c) 5.7%-6.4% and IFG (HbA(1c) levels at 5.7%-6.4% and FPG levels at 5.6-6.9 mmol/L). All subjects were measured for weight, height, waist circumference, blood pressure, fasting plasma glucose, HbA(1c), lipid profile and brachial-ankle pulse wave velocity (baPWV).

Results The mean values of baPWV were 1282 +/- 8, 1311 +/- 10, 1398 +/- 30, and 1418 +/- 27 cm/s (Mean +/- SE) in Normoglycaemia, HbA(1c) 5.7%-6.4% alone, IFG alone and the both HbA(1c) 5.7%-6.4% and IFG groups, respectively. After adjusting for age, gender, blood pressure, BMI and triglyceride, baPWV was significantly higher in subjects with both HbA(1c) 5.7%-6.4% and IFG compared among the subjects with Normoglycaemia (1350 +/- 14 vs. 1301 +/- 6 cm/s, P= 0.002) and HbA1c 5.7%-6.4% alone (1350 +/- 14 vs. 1309 +/- 8 cm/s, P= 0.013).

Conclusion Subjects with pre-diabetes exhibited a greater arterial stiffness.

语种: 英语
所属项目编号: 2008BAI52B03
项目资助者: National Science &amp ; Technology Pillar Program
WOS记录号: WOS:000324858400002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65566
Appears in Collections:北京大学公共卫生学院_期刊论文

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作者单位: 1.Inst Aviat Med AF, Beijing 100142, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Sch Publ Hlth, Dept Epidemiol & Biostat, Beijing 100191, Peoples R China

Recommended Citation:
Shen Li,Zhang Yan Ge,Liu Min,et al. Increased Arterial Stiffness in Subjects with Pre-diabetes among Middle Aged Population in Beijing, China[J]. BIOMEDICAL AND ENVIRONMENTAL SCIENCES,2013,26(9):717-725.
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