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Different Levels in Orexin Concentrations and Risk Factors Associated with Higher Orexin Levels: Comparison between Detoxified Opiate and Methamphetamine Addicts in 5 Chinese Cities
Zhang, Haoran1,2; Lian, Zhi2; Yan, Shiyan3; Bao, Yanping2; Liu, Zhimin2
刊名BIOMED RESEARCH INTERNATIONAL
2013
DOI10.1155/2013/282641
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biotechnology & Applied Microbiology ; Medicine, Research & Experimental
研究领域[WOS]Biotechnology & Applied Microbiology ; Research & Experimental Medicine
关键词[WOS]COCAINE-SEEKING ; INDUCED REINSTATEMENT ; SYNAPTIC PLASTICITY ; MORPHINE-WITHDRAWAL ; NUCLEUS-ACCUMBENS ; ALCOHOL-SEEKING ; OREXIN/HYPOCRETIN ; HYPOCRETINS ; RATS ; OREXINS/HYPOCRETINS
英文摘要

This study sought to explore the degree of orexin levels in Chinese opiate and methamphetamine addicts and the differences between them. The cross-sectional study was conducted among detoxified drug addicts from Mandatory Detoxification Center (MDC) in five Chinese cities. Orexin levels were assayed with radioimmunoassay (RIA). Mann-Whitney U test and Kruskal-Wallis test were used to detect differences across groups, and logistic regression was used to explore the association between orexin levels and characteristics of demographic and drug abuse. Between November 2009 and January 2011, 285 opiates addicts, 112 methamphetamine addicts, and 79 healthy controls were enrolled. At drug withdrawal period, both opiate and methamphetamine addicts had lower median orexin levels than controls, and median orexin levels in opiate addicts were higher than those in methamphetamine addicts (all above p < 0.05). Adjusted odds of the above median concentration of orexin were higher for injection than "chasing the dragon" (AOR = 3.1, 95% CI = 1.2-7.9). No significant factors associated with orexin levels of methamphetamine addicts were found. Development of intervention method on orexin system by different administration routes especially for injected opiate addicts at detoxification phase may be significant and was welcome.

语种英语
WOS记录号WOS:000325424600001
项目编号2009CB522007 ; 2012BAI01B07
资助机构Major State Basic Research Project (973 program) ; National "Twelfth Five-Year" Plan for Science and Technology Support Program, China
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65571
专题北京大学公共卫生学院
中国药物依赖性研究所
作者单位1.Peking Univ, Sch Publ Hlth, Beijing 100191, Peoples R China
2.Peking Univ, Natl Inst Drug Dependence, Beijing 100191, Peoples R China
3.Chinese Acad Med Sci, Inst Basic Res Clin Med, Beijing 100700, Peoples R China
推荐引用方式
GB/T 7714
Zhang, Haoran,Lian, Zhi,Yan, Shiyan,et al. Different Levels in Orexin Concentrations and Risk Factors Associated with Higher Orexin Levels: Comparison between Detoxified Opiate and Methamphetamine Addicts in 5 Chinese Cities[J]. BIOMED RESEARCH INTERNATIONAL,2013.
APA Zhang, Haoran,Lian, Zhi,Yan, Shiyan,Bao, Yanping,&Liu, Zhimin.(2013).Different Levels in Orexin Concentrations and Risk Factors Associated with Higher Orexin Levels: Comparison between Detoxified Opiate and Methamphetamine Addicts in 5 Chinese Cities.BIOMED RESEARCH INTERNATIONAL.
MLA Zhang, Haoran,et al."Different Levels in Orexin Concentrations and Risk Factors Associated with Higher Orexin Levels: Comparison between Detoxified Opiate and Methamphetamine Addicts in 5 Chinese Cities".BIOMED RESEARCH INTERNATIONAL (2013).
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