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学科主题: 公共卫生
题名:
Different Levels in Orexin Concentrations and Risk Factors Associated with Higher Orexin Levels: Comparison between Detoxified Opiate and Methamphetamine Addicts in 5 Chinese Cities
作者: Zhang, Haoran1,2; Lian, Zhi2; Yan, Shiyan3; Bao, Yanping2; Liu, Zhimin2
刊名: BIOMED RESEARCH INTERNATIONAL
发表日期: 2013
DOI: 10.1155/2013/282641
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biotechnology & Applied Microbiology ; Medicine, Research & Experimental
研究领域[WOS]: Biotechnology & Applied Microbiology ; Research & Experimental Medicine
关键词[WOS]: COCAINE-SEEKING ; INDUCED REINSTATEMENT ; SYNAPTIC PLASTICITY ; MORPHINE-WITHDRAWAL ; NUCLEUS-ACCUMBENS ; ALCOHOL-SEEKING ; OREXIN/HYPOCRETIN ; HYPOCRETINS ; RATS ; OREXINS/HYPOCRETINS
英文摘要:

This study sought to explore the degree of orexin levels in Chinese opiate and methamphetamine addicts and the differences between them. The cross-sectional study was conducted among detoxified drug addicts from Mandatory Detoxification Center (MDC) in five Chinese cities. Orexin levels were assayed with radioimmunoassay (RIA). Mann-Whitney U test and Kruskal-Wallis test were used to detect differences across groups, and logistic regression was used to explore the association between orexin levels and characteristics of demographic and drug abuse. Between November 2009 and January 2011, 285 opiates addicts, 112 methamphetamine addicts, and 79 healthy controls were enrolled. At drug withdrawal period, both opiate and methamphetamine addicts had lower median orexin levels than controls, and median orexin levels in opiate addicts were higher than those in methamphetamine addicts (all above p < 0.05). Adjusted odds of the above median concentration of orexin were higher for injection than "chasing the dragon" (AOR = 3.1, 95% CI = 1.2-7.9). No significant factors associated with orexin levels of methamphetamine addicts were found. Development of intervention method on orexin system by different administration routes especially for injected opiate addicts at detoxification phase may be significant and was welcome.

语种: 英语
所属项目编号: 2009CB522007 ; 2012BAI01B07
项目资助者: Major State Basic Research Project (973 program) ; National "Twelfth Five-Year" Plan for Science and Technology Support Program, China
WOS记录号: WOS:000325424600001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65571
Appears in Collections:北京大学公共卫生学院_期刊论文

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作者单位: 1.Peking Univ, Sch Publ Hlth, Beijing 100191, Peoples R China
2.Peking Univ, Natl Inst Drug Dependence, Beijing 100191, Peoples R China
3.Chinese Acad Med Sci, Inst Basic Res Clin Med, Beijing 100700, Peoples R China

Recommended Citation:
Zhang, Haoran,Lian, Zhi,Yan, Shiyan,et al. Different Levels in Orexin Concentrations and Risk Factors Associated with Higher Orexin Levels: Comparison between Detoxified Opiate and Methamphetamine Addicts in 5 Chinese Cities[J]. BIOMED RESEARCH INTERNATIONAL,2013.
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