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学科主题: 药学
题名:
Development of Aminoglycoside Antibiotics Effective Against Resistant Bacterial Strains
作者: Yang, Lin; Ye, Xin-Shan1
关键词: Aminoglycoside antibiotics ; drug-modifying enzymes ; bacterial resistance ; inhibitor ; antimicrobial activity
刊名: CURRENT TOPICS IN MEDICINAL CHEMISTRY
发表日期: 2010-12-01
卷: 10, 期:18, 页:1898-1926
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Medicinal
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: DIMERIZATION INITIATION SITE ; 16S RIBOSOMAL-RNA ; ANTIBACTERIAL ACTIVITY ; NEOMYCIN-B ; BRANCHED AMINOGLYCOSIDES ; BISUBSTRATE INHIBITORS ; TRANSLATION INHIBITORS ; ARBEKACIN DERIVATIVES ; ENTEROCOCCUS-FAECIUM ; DRUG-RESISTANCE
英文摘要:

Aminoglycosides are important broad-spectrum antibiotics used in the therapy of many microbial infections. As the bacterial resistance to antibiotic therapy is appearing as an increasingly significant threat to public health, the development of aminoglycoside antibiotics with extended antibacterial spectrum and potency, devoid of nephro- and ototoxicity, and evading the resistance process returns to the focus of researchers. In this review, various developments brought to the aminoglycoside family of antibiotics effective against resistant bacteria have been described, focused on chemical modifications, drug-modifying enzyme inhibitors, and conformationally constrained analogs, as well as related antibacterial compounds, with the hope to provide information useful in rational design of novel antibiotics addressing bacterial resistance, and paving the way for new perspectives in antimicrobial therapy.

语种: 英语
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000285185000006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65573
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, Beijing 100191, Peoples R China

Recommended Citation:
Yang, Lin,Ye, Xin-Shan. Development of Aminoglycoside Antibiotics Effective Against Resistant Bacterial Strains[J]. CURRENT TOPICS IN MEDICINAL CHEMISTRY,2010,10(18):1898-1926.
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