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Detection of frameshift mutations of RIZ in gastric cancers with microsatellite instability
Pan, Kai-Feng1; Lu, You-Yong2; Liu, Wan-Guo3; Zhang, Lian1; You, Wei-Cheng1
刊名WORLD JOURNAL OF GASTROENTEROLOGY
2004-09-15
10期:18页:2719-2722
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Gastroenterology & Hepatology
研究领域[WOS]Gastroenterology & Hepatology
英文摘要

AIM: To study the frameshift mutations of the retinoblastoma protein-interacting zinc finger gene RIZ in gastric cancer with microsatellite instability, and to identify two coding polyadenosine tracts of RIZ.

METHODS: Frameshift mutations at (A)(8) and (A)(9) tracts of RIZ were detected in 70 human gastric cancer (HGC) specimens by DHPLC and DNA sequencing. Microsatellite instability (MSI) status was assessed by two mononucleotide markers, BAT26 and BAT25, by means of denaturing high-performance liquid chromatography (DHPLC).

RESULTS: In 70 HGC samples, 8 (11.4%) were found positive for instabilities at BAT26 and BAT25. In 7 of the 8 cases with instabilities at both BAT26 and BAT25 (MSI-H), 1 was unstable at BAT26 but stable at BAT25. Frameshift mutations were identified in 4 (57.1%) of the 7 samples with MSI-H in the (A) 9 tract of RIZ without mutations in the (A)(8) tract. In contrast, frameshift mutations were found in neither of the polyadenosine tracts in 63 samples of MSI-L or MSI stable tumors. Pro704 LOH detection in 4 cases with frameshift mutations did not find LOH in these cases.

CONCLUSION: Frameshift mutations of RIZ may play an important role in gastric cancers with MSI.

语种英语
WOS记录号WOS:000208097100021
项目编号G1998051203 ; H020920030130
资助机构Ministry of Science and Technology of China ; Beijing Municipal Commission Foundation for Science and Technology
引用统计
被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65576
专题北京大学临床肿瘤学院_流行病学研究室
北京大学临床肿瘤学院_党院办公室
作者单位1.Peking Univ, Sch Oncol, Dept Canc Epidemiol, Beijing Inst Canc Res,Beijing Canc Hosp, Beijing 100034, Peoples R China
2.Peking Univ, Sch Oncol, Beijing Lab Mol Oncol, Beijing Inst Canc Res,Beijing Canc Hosp, Beijing 100034, Peoples R China
3.Mayo Clin & Mayo Grad Sch Med, Mayo Clin, Div Expt Pathol, Dept Lab Med & Pathol, Rochester, MN 55905 USA
推荐引用方式
GB/T 7714
Pan, Kai-Feng,Lu, You-Yong,Liu, Wan-Guo,et al. Detection of frameshift mutations of RIZ in gastric cancers with microsatellite instability[J]. WORLD JOURNAL OF GASTROENTEROLOGY,2004,10(18):2719-2722.
APA Pan, Kai-Feng,Lu, You-Yong,Liu, Wan-Guo,Zhang, Lian,&You, Wei-Cheng.(2004).Detection of frameshift mutations of RIZ in gastric cancers with microsatellite instability.WORLD JOURNAL OF GASTROENTEROLOGY,10(18),2719-2722.
MLA Pan, Kai-Feng,et al."Detection of frameshift mutations of RIZ in gastric cancers with microsatellite instability".WORLD JOURNAL OF GASTROENTEROLOGY 10.18(2004):2719-2722.
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