IR@PKUHSC  > 北京大学基础医学院
学科主题基础医学
Association of GDF5, SMAD3 and RUNX2 polymorphisms with temporomandibular joint osteoarthritis in female Han Chinese
Xiao, J. -L.1; Meng, J. -H.1; Gan, Y. -H.2; Zhou, C. -Y.3; Ma, X. -C.2
关键词temporomandibular joint osteoarthritis single nucleotide polymorphism GDF5 Smad3 Runx2
刊名JOURNAL OF ORAL REHABILITATION
2015-07-01
DOI10.1111/joor.12286
42期:7页:529-536
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Dentistry, Oral Surgery & Medicine
资助者National Natural Science Foundation of China ; National Natural Science Foundation of China
研究领域[WOS]Dentistry, Oral Surgery & Medicine
关键词[WOS]GENETIC-VARIATION ; EXPRESSION ; SUSCEPTIBILITY ; CARTILAGE ; DISORDERS ; IDENTIFICATION ; PREVALENCE ; SCHIZOPHRENIA ; CHONDROCYTES ; PROTEIN-1
英文摘要

Temporomandibular joint osteoarthritis (TMJOA) is a complex disease and has a strong genetic component in its pathogenesis. Experimental evidence suggests the involvement of biological pathway in the disease. This case-control study was designed to investigate whether five common single nucleotide polymorphisms (SNPs) in GDF5, SMAD3, RUNX2, TGF1 and CHST11, respectively, are associated with TMJOA in female Han Chinese patients. A total of 240 participants were evaluated comprising 114 female patients diagnosed with TMJOA based on Research Diagnostic Criteria for Temporomandibular Disorders and 126 healthy female controls. The SNPs of the five genes in the genomic DNA were examined by sequencing, and their allelic, genotypic and carriage rate frequency distributions, as well as the triple combination of the risk genotypes, were analysed using the logistic regression model. The SNP in GDF5 or SMAD3 showed significant association with TMJOA, a relatively weak association was observed in RUNX2. In the triple combinational analysis, the risk of TMJOA grew 509 times in the patients with five or six risk alleles (P<001). This is the first study to evaluate the association of GDF5, SMAD3, RUNX2, TGF1 and CHST11 with TMJOA in female Han Chinese. Our study suggests that the SNPs of genes related to TGF family might contribute to the risk of TMJOA.

语种英语
所属项目编号31271548
资助者National Natural Science Foundation of China ; National Natural Science Foundation of China
WOS记录号WOS:000356798100007
Citation statistics
Cited Times:4[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65578
Collection北京大学基础医学院
作者单位1.Peking Univ, Sch & Hosp Stomatol, Dept Oral & Maxillofacial Surg, Beijing 100081, Peoples R China
2.Peking Univ, Sch & Hosp Stomatol, Ctr Temporomandibular Joint Disorder & Orofacial, Beijing 100081, Peoples R China
3.Peking Univ, Dept Biochem & Mol Biol, Sch Basic Med Sci, Beijing 100081, Peoples R China
Recommended Citation
GB/T 7714
Xiao, J. -L.,Meng, J. -H.,Gan, Y. -H.,et al. Association of GDF5, SMAD3 and RUNX2 polymorphisms with temporomandibular joint osteoarthritis in female Han Chinese[J]. JOURNAL OF ORAL REHABILITATION,2015,42(7):529-536.
APA Xiao, J. -L.,Meng, J. -H.,Gan, Y. -H.,Zhou, C. -Y.,&Ma, X. -C..(2015).Association of GDF5, SMAD3 and RUNX2 polymorphisms with temporomandibular joint osteoarthritis in female Han Chinese.JOURNAL OF ORAL REHABILITATION,42(7),529-536.
MLA Xiao, J. -L.,et al."Association of GDF5, SMAD3 and RUNX2 polymorphisms with temporomandibular joint osteoarthritis in female Han Chinese".JOURNAL OF ORAL REHABILITATION 42.7(2015):529-536.
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