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学科主题: 基础医学
题名:
Association of GDF5, SMAD3 and RUNX2 polymorphisms with temporomandibular joint osteoarthritis in female Han Chinese
作者: Xiao, J. -L.1; Meng, J. -H.1; Gan, Y. -H.2; Zhou, C. -Y.3; Ma, X. -C.2
关键词: temporomandibular joint ; osteoarthritis ; single nucleotide polymorphism ; GDF5 ; Smad3 ; Runx2
刊名: JOURNAL OF ORAL REHABILITATION
发表日期: 2015-07-01
DOI: 10.1111/joor.12286
卷: 42, 期:7, 页:529-536
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Dentistry, Oral Surgery & Medicine
研究领域[WOS]: Dentistry, Oral Surgery & Medicine
关键词[WOS]: GENETIC-VARIATION ; EXPRESSION ; SUSCEPTIBILITY ; CARTILAGE ; DISORDERS ; IDENTIFICATION ; PREVALENCE ; SCHIZOPHRENIA ; CHONDROCYTES ; PROTEIN-1
英文摘要:

Temporomandibular joint osteoarthritis (TMJOA) is a complex disease and has a strong genetic component in its pathogenesis. Experimental evidence suggests the involvement of biological pathway in the disease. This case-control study was designed to investigate whether five common single nucleotide polymorphisms (SNPs) in GDF5, SMAD3, RUNX2, TGF1 and CHST11, respectively, are associated with TMJOA in female Han Chinese patients. A total of 240 participants were evaluated comprising 114 female patients diagnosed with TMJOA based on Research Diagnostic Criteria for Temporomandibular Disorders and 126 healthy female controls. The SNPs of the five genes in the genomic DNA were examined by sequencing, and their allelic, genotypic and carriage rate frequency distributions, as well as the triple combination of the risk genotypes, were analysed using the logistic regression model. The SNP in GDF5 or SMAD3 showed significant association with TMJOA, a relatively weak association was observed in RUNX2. In the triple combinational analysis, the risk of TMJOA grew 509 times in the patients with five or six risk alleles (P<001). This is the first study to evaluate the association of GDF5, SMAD3, RUNX2, TGF1 and CHST11 with TMJOA in female Han Chinese. Our study suggests that the SNPs of genes related to TGF family might contribute to the risk of TMJOA.

语种: 英语
所属项目编号: 31271548
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000356798100007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65578
Appears in Collections:基础医学院_期刊论文

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作者单位: 1.Peking Univ, Sch & Hosp Stomatol, Dept Oral & Maxillofacial Surg, Beijing 100081, Peoples R China
2.Peking Univ, Sch & Hosp Stomatol, Ctr Temporomandibular Joint Disorder & Orofacial, Beijing 100081, Peoples R China
3.Peking Univ, Dept Biochem & Mol Biol, Sch Basic Med Sci, Beijing 100081, Peoples R China

Recommended Citation:
Xiao, J. -L.,Meng, J. -H.,Gan, Y. -H.,et al. Association of GDF5, SMAD3 and RUNX2 polymorphisms with temporomandibular joint osteoarthritis in female Han Chinese[J]. JOURNAL OF ORAL REHABILITATION,2015,42(7):529-536.
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