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学科主题: 临床医学
题名:
Plasma-soluble urokinase-type plasminogen activator receptor levels are associated with clinical and pathological activities in lupus nephritis: a large cohort study from China
作者: Qin, D. D.1,2,3,4,5; Song, D.1,2,3,4; Huang, J.1,2,3,4; Yu, F.1,2,3,4; Zhao, M. H.1,2,3,4,6
关键词: Lupus nephritis ; systemic lupus erythematosus ; uPA ; uPAR
刊名: LUPUS
发表日期: 2015-05-01
DOI: 10.1177/0961203314558857
卷: 24, 期:6, 页:546-557
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Rheumatology
研究领域[WOS]: Rheumatology
关键词[WOS]: HIV-INFECTED PATIENTS ; NECROSIS-FACTOR-ALPHA ; DISEASE-ACTIVITY ; SERUM-LEVELS ; IN-VIVO ; ERYTHEMATOSUS ; PROTEIN ; UPAR ; EXPRESSION ; SYSTEM
英文摘要:

Background In this study, we detected plasma urokinase plasminogen activator (uPA) and soluble urokinase-type plasminogen activator receptor (uPAR) levels in Chinese lupus nephritis patients from a large cohort. The associations between plasma uPA and soluble uPAR and clinico-pathological characteristics were further analyzed.

Methods The levels of plasma uPA and soluble uPAR were detected by ELISA in 202 patients with active lupus nephritis, 17 systemic lupus erythematosus (SLE) patients without renal involvement and 21 normal controls.

Results There were no significant differences in the levels of the average plasma uPA among the lupus nephritis group, non-renal SLE group and normal control group (p=0.129). The plasma-soluble uPAR level in the lupus nephritis group was significantly higher than that in the non-renal involvement SLE group (p=0.004) and that in normal controls (p<0.001). The plasma uPAR levels were positively associated with SLEDAI scores (r=0.215, p=0.007). In renal pathological data, there was significant difference of plasma-soluble uPAR levels among various pathological classes, which was the highest in the class IV group (p=0.012). The level of plasma-soluble uPAR was found to be a risk factor for long-term renal outcomes in lupus nephritis by univariate survival analysis (p=0.013, HR=6.326, 95% CI: 1.466-27.298).

Conclusions Our study showed that the significantly increased plasma levels of soluble uPAR could be found in active lupus nephritis, and they were associated with some clinico-pathological features. Its involvement in the pathogenesis of lupus nephritis warrants further study.

语种: 英语
所属项目编号: 81100497
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000353586100003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65580
Appears in Collections:北京大学第一临床医学院_肾脏内科_期刊论文

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作者单位: 1.Peking Univ, Hosp 1, Dept Med, Div Renal, Beijing 100034, Peoples R China
2.Peking Univ, Inst Nephrol, Beijing 100034, Peoples R China
3.Minist Hlth China, Key Lab Renal Dis, Beijing 100034, Peoples R China
4.Minist Educ China, Key Lab Chron Kidney Dis Prevent & Treatment, Beijing 100034, Peoples R China
5.Harbin Med Univ, Affiliated Hosp 2, Dept Nephrol, Harbin, Heilongjiang, Peoples R China
6.Peking Tsinghua Ctr Life Sci, Beijing, Peoples R China

Recommended Citation:
Qin, D. D.,Song, D.,Huang, J.,et al. Plasma-soluble urokinase-type plasminogen activator receptor levels are associated with clinical and pathological activities in lupus nephritis: a large cohort study from China[J]. LUPUS,2015,24(6):546-557.
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