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Furanodiene, a Natural Product, Inhibits Breast Cancer Growth Both in vitro and in vivo
Zhong, Zhangfeng1,2; Dang, Yuanye1,2; Yuan, Xia3; Guo, Wei; Li, Yingbo1,2; Tan, Wen1,2; Cui, Jingrong3; Lu, Jinjian1,2; Zhang, Qingwen1,2; Chen, Xiuping1,2; Wang, Yitao1,2
关键词Furanodiene Breast cancer Proliferation Cell cycle Apoptosis
刊名CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
2012
DOI10.1159/000341457
30期:3页:778-790
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cell Biology ; Physiology
研究领域[WOS]Cell Biology ; Physiology
关键词[WOS]CELL-CYCLE ARREST ; PRESSURIZED-LIQUID-EXTRACTION ; TRADITIONAL CHINESE MEDICINE ; D-GALACTOSAMINE/LIPOPOLYSACCHARIDE ; ZEDOARIAE RHIZOMA ; CURCUMA RHIZOMES ; LIVER-INJURY ; APOPTOSIS ; ACTIVATION ; SESQUITERPENES
英文摘要

Purpose: Previous studies have reported that the Curcuma wenyujin Y.H. Chen et C. Ling extract, which has a high furanodiene content, showed anti-cancer effects in breast cancer cells in vitro. The present study was designed to evaluate the in vitro and in vivo anti-cancer activity of furanodiene. Methods: The in vitro effects of furanodiene were examined on two human breast cancer cell lines, MCF-7 and MDA-MB-231 cells. Assays of proliferation, LDH release, mitochondrial membrane potential (Delta Psi m), cell cycle distribution, apoptosis and relevant signaling pathways were performed. The in vivo effect was determined with MCF-7 tumor xenograft model in nude mice. Results: Furanodiene significantly inhibited the proliferation and increased the LDH release in both cell lines in a dose-dependent manner. Delta Psi m depolarization, chromatin condensation, and DNA fragmentation were also observed after furanodiene treatment. Furanodiene dose-dependently induced cell cycle arrest at the G0/G1 phase. The protein expressions of p-cyclin D1, total cyclin D1, p-CDK2, total CDK2, p-Rb, total Rb, Bcl-xL, and Akt were significantly inhibited by furanodiene, whereas the protein expressions of Bad and Bax, and the proteolytic cleavage of caspase-9, caspase-7, and poly-ADP-ribose polymerase (PARP) were dramatically increased. Furthermore, the z-VAD-fmk markedly reversed the furanodiene-induced cell cytotoxicity, the proteolytic cleavage of caspase-9, and DNA fragmentation but did not affect the proteolytic cleavage of PARP, whereas the Akt inhibitor VIII increased the furanodiene-induced cytotoxicity and PARP cleavage. In addition, furanodiene dose-dependently suppressed the tumor growth in vivo, achieving 32% and 54% inhibition rates after intraperitoneal injection of 15 mg/kg and 30 mg/kg, respectively. Conclusions: Taken together, we concluded that furanodiene suppresses breast cancer cell growth both in vitro and in vivo and could be a new lead compound for breast cancer chemotherapy. Copyright (C) 2012 S. Karger AG, Basel

语种英语
WOS记录号WOS:000307533600025
项目编号045/2011/A ; 077/2011/A3 ; UL016/09-Y4/CMS/WYT01/ICMS ; MYRG208(Y2-L4)-ICMS11-WYT
资助机构Macao Science and Technology Development Fund ; University of Macau
引用统计
被引频次:33[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65581
专题北京大学药学院
北京大学药学院_分子与细胞药理学系
作者单位1.Univ Macau, Inst Chinese Med Sci, Macao, Peoples R China
2.Univ Macau, State Key Lab Qual Res Chinese Med, Macao, Peoples R China
3.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Zhong, Zhangfeng,Dang, Yuanye,Yuan, Xia,et al. Furanodiene, a Natural Product, Inhibits Breast Cancer Growth Both in vitro and in vivo[J]. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY,2012,30(3):778-790.
APA Zhong, Zhangfeng.,Dang, Yuanye.,Yuan, Xia.,Guo, Wei.,Li, Yingbo.,...&Wang, Yitao.(2012).Furanodiene, a Natural Product, Inhibits Breast Cancer Growth Both in vitro and in vivo.CELLULAR PHYSIOLOGY AND BIOCHEMISTRY,30(3),778-790.
MLA Zhong, Zhangfeng,et al."Furanodiene, a Natural Product, Inhibits Breast Cancer Growth Both in vitro and in vivo".CELLULAR PHYSIOLOGY AND BIOCHEMISTRY 30.3(2012):778-790.
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