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学科主题: 药学
题名:
Solid-phase synthesis and evaluation of TAR RNA targeted beta-carboline-nucleoside conjugates
作者: Zhao, Peng; Jin, Hong-Wei; Yang, Zhen-Jun; Zhang, Liang-Ren; Zhang, Li-He
刊名: ORGANIC & BIOMOLECULAR CHEMISTRY
发表日期: 2008-10-21
DOI: 10.1039/b809598a
卷: 6, 期:20, 页:3741-3750
收录类别: SCI ; IC
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Organic
研究领域[WOS]: Chemistry
关键词[WOS]: IMMUNODEFICIENCY-VIRUS TYPE-1 ; CIRCULAR-DICHROISM ; INTERACTION INHIBITORS ; PACKAGING REGION ; HIV-1 TAR ; BINDING ; DERIVATIVES ; ANALOGS ; RECOGNITION ; PROTEIN
英文摘要:

Four types of beta-carboline-nucleoside conjugates were synthesized. The binding affinities of these beta-carboline-nucleoside conjugates 4-11, 13 and 15 to TAR RNA were evaluated by affinity capillary electrophoresis. The data of binding affinities to TAR RNA show that conjugates 9 and 13 are stronger binders than the parent compound MC3. Computer modeling indicates that the P-carboline-nucleoside conjugate 13 can fit to the UCU three-nucleotide bulge region of TAR RNA.

语种: 英语
所属项目编号: 90713005 ; 2004CB518904
项目资助者: National Natural Science Foundation of China ; Ministry of Science and Technology of China
WOS记录号: WOS:000260429100014
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65582
Appears in Collections:北京大学药学院_期刊论文

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作者单位: Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China

Recommended Citation:
Zhao, Peng,Jin, Hong-Wei,Yang, Zhen-Jun,et al. Solid-phase synthesis and evaluation of TAR RNA targeted beta-carboline-nucleoside conjugates[J]. ORGANIC & BIOMOLECULAR CHEMISTRY,2008,6(20):3741-3750.
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