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Solid-phase synthesis and evaluation of TAR RNA targeted beta-carboline-nucleoside conjugates
Zhao, Peng; Jin, Hong-Wei; Yang, Zhen-Jun; Zhang, Liang-Ren; Zhang, Li-He
刊名ORGANIC & BIOMOLECULAR CHEMISTRY
2008-10-21
DOI10.1039/b809598a
6期:20页:3741-3750
收录类别SCI ; IC
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Organic
资助者National Natural Science Foundation of China ; Ministry of Science and Technology of China ; National Natural Science Foundation of China ; Ministry of Science and Technology of China
研究领域[WOS]Chemistry
关键词[WOS]IMMUNODEFICIENCY-VIRUS TYPE-1 ; CIRCULAR-DICHROISM ; INTERACTION INHIBITORS ; PACKAGING REGION ; HIV-1 TAR ; BINDING ; DERIVATIVES ; ANALOGS ; RECOGNITION ; PROTEIN
英文摘要

Four types of beta-carboline-nucleoside conjugates were synthesized. The binding affinities of these beta-carboline-nucleoside conjugates 4-11, 13 and 15 to TAR RNA were evaluated by affinity capillary electrophoresis. The data of binding affinities to TAR RNA show that conjugates 9 and 13 are stronger binders than the parent compound MC3. Computer modeling indicates that the P-carboline-nucleoside conjugate 13 can fit to the UCU three-nucleotide bulge region of TAR RNA.

语种英语
所属项目编号90713005 ; 2004CB518904
资助者National Natural Science Foundation of China ; Ministry of Science and Technology of China ; National Natural Science Foundation of China ; Ministry of Science and Technology of China
WOS记录号WOS:000260429100014
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65582
专题北京大学药学院
作者单位Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Zhao, Peng,Jin, Hong-Wei,Yang, Zhen-Jun,et al. Solid-phase synthesis and evaluation of TAR RNA targeted beta-carboline-nucleoside conjugates[J]. ORGANIC & BIOMOLECULAR CHEMISTRY,2008,6(20):3741-3750.
APA Zhao, Peng,Jin, Hong-Wei,Yang, Zhen-Jun,Zhang, Liang-Ren,&Zhang, Li-He.(2008).Solid-phase synthesis and evaluation of TAR RNA targeted beta-carboline-nucleoside conjugates.ORGANIC & BIOMOLECULAR CHEMISTRY,6(20),3741-3750.
MLA Zhao, Peng,et al."Solid-phase synthesis and evaluation of TAR RNA targeted beta-carboline-nucleoside conjugates".ORGANIC & BIOMOLECULAR CHEMISTRY 6.20(2008):3741-3750.
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