| 学科主题 | 药学 |
| Solid-phase synthesis and evaluation of TAR RNA targeted beta-carboline-nucleoside conjugates | |
| Zhao, Peng; Jin, Hong-Wei; Yang, Zhen-Jun; Zhang, Liang-Ren; Zhang, Li-He | |
| 刊名 | ORGANIC & BIOMOLECULAR CHEMISTRY
 |
| 2008-10-21 | |
| DOI | 10.1039/b809598a |
| 卷 | 6期:20页:3741-3750 |
| 收录类别 | SCI ; IC |
| 文章类型 | Article |
| WOS标题词 | Science & Technology |
| 类目[WOS] | Chemistry, Organic |
| 资助者 | National Natural Science Foundation of China ; Ministry of Science and Technology of China ; National Natural Science Foundation of China ; Ministry of Science and Technology of China |
| 研究领域[WOS] | Chemistry |
| 关键词[WOS] | IMMUNODEFICIENCY-VIRUS TYPE-1 ; CIRCULAR-DICHROISM ; INTERACTION INHIBITORS ; PACKAGING REGION ; HIV-1 TAR ; BINDING ; DERIVATIVES ; ANALOGS ; RECOGNITION ; PROTEIN |
| 英文摘要 | Four types of beta-carboline-nucleoside conjugates were synthesized. The binding affinities of these beta-carboline-nucleoside conjugates 4-11, 13 and 15 to TAR RNA were evaluated by affinity capillary electrophoresis. The data of binding affinities to TAR RNA show that conjugates 9 and 13 are stronger binders than the parent compound MC3. Computer modeling indicates that the P-carboline-nucleoside conjugate 13 can fit to the UCU three-nucleotide bulge region of TAR RNA. |
| 语种 | 英语 |
| 所属项目编号 | 90713005 ; 2004CB518904 |
| 资助者 | National Natural Science Foundation of China ; Ministry of Science and Technology of China ; National Natural Science Foundation of China ; Ministry of Science and Technology of China |
| WOS记录号 | WOS:000260429100014 |
| Citation statistics | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.bjmu.edu.cn/handle/400002259/65582 |
| Collection | 北京大学药学院 |
| 作者单位 | Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China |
| Recommended Citation GB/T 7714 | Zhao, Peng,Jin, Hong-Wei,Yang, Zhen-Jun,et al. Solid-phase synthesis and evaluation of TAR RNA targeted beta-carboline-nucleoside conjugates[J]. ORGANIC & BIOMOLECULAR CHEMISTRY,2008,6(20):3741-3750. |
| APA | Zhao, Peng,Jin, Hong-Wei,Yang, Zhen-Jun,Zhang, Liang-Ren,&Zhang, Li-He.(2008).Solid-phase synthesis and evaluation of TAR RNA targeted beta-carboline-nucleoside conjugates.ORGANIC & BIOMOLECULAR CHEMISTRY,6(20),3741-3750. |
| MLA | Zhao, Peng,et al."Solid-phase synthesis and evaluation of TAR RNA targeted beta-carboline-nucleoside conjugates".ORGANIC & BIOMOLECULAR CHEMISTRY 6.20(2008):3741-3750. |
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