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Effect of hCG priming on embryonic development of immature oocytes collected from unstimulated women with polycystic ovarian syndrome
Zheng, Xiaoying1,2; Wang, Lina1,2; Zhen, Xiumei1,2; Lian, Ying1,2; Liu, Ping1,2; Qiao, Jie1,2
关键词Polycystic ovarian syndrome In vitro maturation hCG priming
刊名REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
2012-05-24
DOI10.1186/1477-7827-10-40
10
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Endocrinology & Metabolism ; Reproductive Biology
研究领域[WOS]Endocrinology & Metabolism ; Reproductive Biology
关键词[WOS]IN-VITRO MATURATION ; LUTEINIZING-HORMONE ; GRANULOSA-CELLS ; CUMULUS CELLS ; FERTILIZATION ; EXPRESSION ; FOLLICULOGENESIS ; COMPETENCE ; CRITERIA ; RECEPTOR
英文摘要

Backgroud: The effect of hCG priming on oocyte maturation and subsequently outcome in IVM cycles has remained a debated issue. A randomized controlled study was performed to investigate whether or not hCG priming prior to oocyte aspiration can improve the developmental competence of immature oocytes from unstimulated ovaries in women with polycystic ovarian syndrome (PCOS).

Methods: Eighty two patients with PCOS underwent IVM cycles. Each patient was randomly assigned to the hCG-primed (10,000 IU) or non-primed groups 36-38 hours before oocyte retrieval depending on the computerized random table. After the oocytes had in vitro matured, fertilization, culture and embryo transfer were performed.

Results: The average number of cumulus-oocyte complexes (COCs) recovered was 13.80 and 14.35 in the hCG-primed and non-primed groups, respectively (p>0.05). The maturation rate of COCs was significantly improved in the hCG-primed group (55.43% vs. 42.29%; p<0.05). The fertilization and cleavage rates were comparable between the groups. The hCG-primed and non-primed groups did not differ with respect to the clinical pregnancy (37.50% vs. 50.00%), live birth (22.50% vs. 30.95%), and implantation rates (32.86% vs. 32.56%). The pregnancy losses was 6 (40.00%) of 15 clinical pregnancies in the hCG-primed group, and 8 (38.10%) of 21 clinical pregnancies in the non-primed group.

Conclusions: While a significant improvement in the nuclear maturation rate of immature oocytes was observed in hCG-primed IVM cycles with PCOS patients, the use of hCG prior to oocyte retrieval did not improve the subsequent embryo developmental competence. The high rate of pregnancy loss in IVM cycles should receive more attention.

语种英语
WOS记录号WOS:000311414000001
项目编号30825038 ; 2011CB944500
资助机构National Science Fund for Distinguished Young Scholars ; State Basic Research Development Program of China (973 Program)
引用统计
被引频次:11[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65591
专题北京大学第三临床医学院_生殖医学中心
作者单位1.Peking Univ, Hosp 3, Ctr Reprod Med, Dept Obstet & Gynecol, Beijing 100191, Peoples R China
2.Minist Educ, Key Lab Assisted Reprod, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Zheng, Xiaoying,Wang, Lina,Zhen, Xiumei,et al. Effect of hCG priming on embryonic development of immature oocytes collected from unstimulated women with polycystic ovarian syndrome[J]. REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY,2012,10.
APA Zheng, Xiaoying,Wang, Lina,Zhen, Xiumei,Lian, Ying,Liu, Ping,&Qiao, Jie.(2012).Effect of hCG priming on embryonic development of immature oocytes collected from unstimulated women with polycystic ovarian syndrome.REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY,10.
MLA Zheng, Xiaoying,et al."Effect of hCG priming on embryonic development of immature oocytes collected from unstimulated women with polycystic ovarian syndrome".REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY 10(2012).
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