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学科主题: 精神卫生
题名:
Intramuscular Ziprasidone Versus Haloperidol for Managing Agitation in Chinese Patients With Schizophrenia
作者: Zhang, Hongyan1; Wang, Gang2; Zhao, Jingping3; Xie, Shiping4; Xu, Xiufeng5; Shi, Jianguo6; Deng, Hehuang7; Li, Keqing8; Gao, Chengge9; Wang, Xiaoping10; Vanderburg, Douglas11; Pan, Sharon11; Tang, Haiyun11; Shu, Liang1; Karayal, Onur N.11
关键词: ziprasidone ; agitation ; intramuscular ; schizophrenia
刊名: JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY
发表日期: 2013-04-01
DOI: 10.1097/JCP.0b013e3182839612
卷: 33, 期:2, 页:178-185
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy ; Psychiatry
研究领域[WOS]: Pharmacology & Pharmacy ; Psychiatry
关键词[WOS]: SCHIZOAFFECTIVE DISORDER ; ACUTE EXACERBATION ; GENDER-DIFFERENCES ; NONINFERIORITY ; PREVALENCE ; CLOZAPINE ; PSYCHOSIS ; DRUGS ; BLIND ; BPRS
英文摘要:

Intramuscular (IM) antipsychotics are preferred for efficient control of agitation symptoms. Previous studies have demonstrated that IM ziprasidone is efficacious and safe for treatment of agitation in schizophrenia. However, clinicians now recognize that racial differences may contribute to altered therapeutic response and tolerability. This study compared the efficacy and tolerability of IM ziprasidone versus IM haloperidol for the management of agitation in Chinese subjects with schizophrenia. Subjects with acute schizophrenia were randomized to either ziprasidone (n = 189, 10 to 20 mg as required up to a maximum of 40 mg/d) or haloperidol (n = 187, 5 mg every 4 to 8 hours to a maximum of 20 mg/d) for 3 days. Psychiatric assessments and adverse events were assessed at baseline, 2, 4, 24, 48, and 72 hours. In the ziprasidone group, 2.1% of subjects discontinued versus 3.7% in the haloperidol group. The least squares mean change (SE) from baseline to 72 hours in Brief Psychiatry Rating Scale total score was -17.32(0.7) for ziprasidone (n = 167) and -18.44(0.7) for haloperidol (n = 152), with a 95% confidence interval treatment difference of -0.7 to 2.9. Fewer subjects experienced adverse events after ziprasidone (n = 54, 28.6%) than haloperidol (n = 116, 62.0%), with a notably higher incidence of extrapyramidal symptoms in the haloperidol group (n = 69, 36.9%) compared to the ziprasidone group (n = 4, 2.1%). For controlling agitation in schizophrenia in this Chinese study, ziprasidone had a favorable tolerability profile and comparable efficacy and safety compared to haloperidol.

语种: 英语
项目资助者: Pfizer Inc.
WOS记录号: WOS:000316303700006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65593
Appears in Collections:北京大学精神卫生研究所_期刊论文

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作者单位: 1.Peking Univ, Hosp 6, Inst Mental Hlth, Beijing 100871, Peoples R China
2.Capital Med Univ, Beijing Anding Hosp, Beijing, Peoples R China
3.Cent S Univ, Xiangya Hosp 2, Changsha, Hunan, Peoples R China
4.Kun Ming Med Coll, Affiliated Hosp 1, Kunming, Peoples R China
5.Xi An Jiao Tong Univ, Coll Med, Affiliated Hosp 1, Xian 710049, Peoples R China
6.Nanjing Brain Hosp, Nanjing, Jiangsu, Peoples R China
7.Xian Mental Hlth Ctr, Xian, Peoples R China
8.Guangzhou Psychiat Hosp, Guangzhou, Guangdong, Peoples R China
9.Hebei Mental Hlth Ctr, Baoding, Peoples R China
10.Wuhan Univ, Ren Min Hosp, Wuhan 430072, Peoples R China
11.Pfizer Inc, New York, NY 10017 USA

Recommended Citation:
Zhang, Hongyan,Wang, Gang,Zhao, Jingping,et al. Intramuscular Ziprasidone Versus Haloperidol for Managing Agitation in Chinese Patients With Schizophrenia[J]. JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY,2013,33(2):178-185.
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