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Intramuscular Ziprasidone Versus Haloperidol for Managing Agitation in Chinese Patients With Schizophrenia
Zhang, Hongyan1; Wang, Gang2; Zhao, Jingping3; Xie, Shiping4; Xu, Xiufeng5; Shi, Jianguo6; Deng, Hehuang7; Li, Keqing8; Gao, Chengge9; Wang, Xiaoping10; Vanderburg, Douglas11; Pan, Sharon11; Tang, Haiyun11; Shu, Liang1; Karayal, Onur N.11
关键词ziprasidone agitation intramuscular schizophrenia
刊名JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY
2013-04-01
DOI10.1097/JCP.0b013e3182839612
33期:2页:178-185
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pharmacology & Pharmacy ; Psychiatry
研究领域[WOS]Pharmacology & Pharmacy ; Psychiatry
关键词[WOS]SCHIZOAFFECTIVE DISORDER ; ACUTE EXACERBATION ; GENDER-DIFFERENCES ; NONINFERIORITY ; PREVALENCE ; CLOZAPINE ; PSYCHOSIS ; DRUGS ; BLIND ; BPRS
英文摘要

Intramuscular (IM) antipsychotics are preferred for efficient control of agitation symptoms. Previous studies have demonstrated that IM ziprasidone is efficacious and safe for treatment of agitation in schizophrenia. However, clinicians now recognize that racial differences may contribute to altered therapeutic response and tolerability. This study compared the efficacy and tolerability of IM ziprasidone versus IM haloperidol for the management of agitation in Chinese subjects with schizophrenia. Subjects with acute schizophrenia were randomized to either ziprasidone (n = 189, 10 to 20 mg as required up to a maximum of 40 mg/d) or haloperidol (n = 187, 5 mg every 4 to 8 hours to a maximum of 20 mg/d) for 3 days. Psychiatric assessments and adverse events were assessed at baseline, 2, 4, 24, 48, and 72 hours. In the ziprasidone group, 2.1% of subjects discontinued versus 3.7% in the haloperidol group. The least squares mean change (SE) from baseline to 72 hours in Brief Psychiatry Rating Scale total score was -17.32(0.7) for ziprasidone (n = 167) and -18.44(0.7) for haloperidol (n = 152), with a 95% confidence interval treatment difference of -0.7 to 2.9. Fewer subjects experienced adverse events after ziprasidone (n = 54, 28.6%) than haloperidol (n = 116, 62.0%), with a notably higher incidence of extrapyramidal symptoms in the haloperidol group (n = 69, 36.9%) compared to the ziprasidone group (n = 4, 2.1%). For controlling agitation in schizophrenia in this Chinese study, ziprasidone had a favorable tolerability profile and comparable efficacy and safety compared to haloperidol.

语种英语
WOS记录号WOS:000316303700006
资助机构Pfizer Inc.
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65593
专题北京大学精神卫生研究所
北京大学医学图书馆_采访编目部
作者单位1.Peking Univ, Hosp 6, Inst Mental Hlth, Beijing 100871, Peoples R China
2.Capital Med Univ, Beijing Anding Hosp, Beijing, Peoples R China
3.Cent S Univ, Xiangya Hosp 2, Changsha, Hunan, Peoples R China
4.Kun Ming Med Coll, Affiliated Hosp 1, Kunming, Peoples R China
5.Xi An Jiao Tong Univ, Coll Med, Affiliated Hosp 1, Xian 710049, Peoples R China
6.Nanjing Brain Hosp, Nanjing, Jiangsu, Peoples R China
7.Xian Mental Hlth Ctr, Xian, Peoples R China
8.Guangzhou Psychiat Hosp, Guangzhou, Guangdong, Peoples R China
9.Hebei Mental Hlth Ctr, Baoding, Peoples R China
10.Wuhan Univ, Ren Min Hosp, Wuhan 430072, Peoples R China
11.Pfizer Inc, New York, NY 10017 USA
推荐引用方式
GB/T 7714
Zhang, Hongyan,Wang, Gang,Zhao, Jingping,et al. Intramuscular Ziprasidone Versus Haloperidol for Managing Agitation in Chinese Patients With Schizophrenia[J]. JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY,2013,33(2):178-185.
APA Zhang, Hongyan.,Wang, Gang.,Zhao, Jingping.,Xie, Shiping.,Xu, Xiufeng.,...&Karayal, Onur N..(2013).Intramuscular Ziprasidone Versus Haloperidol for Managing Agitation in Chinese Patients With Schizophrenia.JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY,33(2),178-185.
MLA Zhang, Hongyan,et al."Intramuscular Ziprasidone Versus Haloperidol for Managing Agitation in Chinese Patients With Schizophrenia".JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY 33.2(2013):178-185.
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